Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
出版年份 2016 全文链接
标题
Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters
作者
关键词
-
出版物
DRUG METABOLISM REVIEWS
Volume 48, Issue 4, Pages 541-567
出版商
Informa UK Limited
发表日期
2016-06-20
DOI
10.1080/03602532.2016.1197239
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- miR-340 Reverses Cisplatin Resistance of Hepatocellular Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway
- (2015) Liang Shi et al. Asian Pacific Journal of Cancer Prevention
- Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism
- (2015) Dionysios V. Chartoumpekis et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer
- (2015) Yota Kawasaki et al. BMC CANCER
- Cryptotanshinone Reverses Cisplatin Resistance of Human Lung Carcinoma A549 Cells through Down-Regulating Nrf2 Pathway
- (2015) Chen Xia et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Nrf2-mediated adaptive response to methyl glyoxal in HepG2 cells involves the induction of AKR7A2
- (2015) Dan Li et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Metabolism of doxorubicin to the cardiotoxic metabolite doxorubicinol is increased in a mouse model of chronic glutathione deficiency: A potential role for carbonyl reductase 3
- (2015) Christopher M. Schaupp et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment
- (2015) Ganesh Venkatraman et al. FASEB JOURNAL
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
- (2015) Lauren E. Tebay et al. FREE RADICAL BIOLOGY AND MEDICINE
- Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment
- (2015) Eui Jung Moon et al. FREE RADICAL BIOLOGY AND MEDICINE
- The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression
- (2015) Violetta Krajka-Kuźniak et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- 3′,4′,5′,5,7-Pentamethoxyflavone Sensitizes Cisplatin-Resistant A549 Cells to Cisplatin by Inhibition of Nrf2 Pathway
- (2015) Xiangyu Hou et al. MOLECULES AND CELLS
- Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients
- (2015) Alicia Romero-Lorca et al. PLoS One
- Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
- (2015) In-geun Ryoo et al. Oncotarget
- Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis
- (2015) Zhipeng Wang et al. Scientific Reports
- Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1
- (2015) Sally-Anne Heasman et al. Oncotarget
- Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer
- (2014) Xiu-Feng Hu et al. Asian Pacific Journal of Cancer Prevention
- Luteolin Sensitizes Two Oxaliplatin-Resistant Colorectal Cancer Cell Lines to Chemotherapeutic Drugs Via Inhibition of the Nrf2 Pathway
- (2014) Song Chian et al. Asian Pacific Journal of Cancer Prevention
- Wogonin reverses multi-drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway
- (2014) Xuefen Xu et al. BIOCHEMICAL PHARMACOLOGY
- HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib
- (2014) Anna Lisa Furfaro et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Nrf2, the master redox switch: The Achilles' heel of ovarian cancer?
- (2014) Monique G.P. van der Wijst et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes
- (2014) Min Zhang et al. BMC CANCER
- The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer
- (2014) Zhiwei Chen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Importance of ABCC1 for cancer therapy and prognosis
- (2014) Tereza Kunická et al. DRUG METABOLISM REVIEWS
- Upregulation of glucose metabolism by NF-κB2/p52 mediates enzalutamide resistance in castration-resistant prostate cancer cells
- (2014) Yuanyuan Cui et al. ENDOCRINE-RELATED CANCER
- Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs
- (2014) Xiu Jun Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Proteasome Inhibition Induces Both Antioxidant and Hb F Responses in Sickle Cell DiseaseViathe Nrf2 Pathway
- (2014) Vinod Pullarkat et al. HEMOGLOBIN
- ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling
- (2014) Erhong Meng et al. PLoS One
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
- (2014) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- The pentose phosphate pathway and cancer
- (2014) Krushna C. Patra et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer
- (2014) Annette Hayden et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation
- (2014) K A Kang et al. Cell Death & Disease
- Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine
- (2014) Auke D Adema et al. SpringerPlus
- The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance
- (2013) Radosław Januchowski et al. BIOMEDICINE & PHARMACOTHERAPY
- RXR Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
- (2013) H. Wang et al. CANCER RESEARCH
- Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
- (2013) Ai-Mei Gao et al. CARCINOGENESIS
- Stem cell-like ALDHbrightcellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin
- (2013) BRUNA COROMINAS-FAJA et al. CELL CYCLE
- Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway
- (2013) Ai-Mei Gao et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Pharmacogenetics, Pharmacogenomics and Epigenetics of Nrf2-regulated Xenobioticmetabolizing Enzymes and Transporters by Dietary Phytochemical and Cancer Chemoprevention
- (2013) Tien-Yuan Wu et al. CURRENT DRUG METABOLISM
- MicroRNAs as therapeutic targets in chemoresistance
- (2013) Michela Garofalo et al. DRUG RESISTANCE UPDATES
- Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma
- (2013) Anja Urbschat et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Oncogenic functions of the transcription factor Nrf2
- (2013) Irene Gañán-Gómez et al. FREE RADICAL BIOLOGY AND MEDICINE
- Regulation of Nrf2—an update
- (2013) Suryakant K. Niture et al. FREE RADICAL BIOLOGY AND MEDICINE
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- Activation of Nrf2-Antioxidant Response Element Mediated Glutamate Cysteine Ligase Expression in Hepatoma Cell line by Homocysteine
- (2013) Monireh Mani et al. Hepatitis Monthly
- Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies
- (2013) Melanie Theodore Malloy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Somatic Mutation of the KEAP1 Gene in Malignant Melanoma Is Involved in Aberrant NRF2 Activation and an Increase in Intrinsic Drug Resistance
- (2013) Shinpei Miura et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines
- (2013) Hanna Piotrowska et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1
- (2013) Toshiaki Fukutomi et al. MOLECULAR AND CELLULAR BIOLOGY
- Genetic variations inTERT-CLPTM1Llocus are associated with risk of lung cancer in chinese population
- (2013) Rong Zhong et al. MOLECULAR CARCINOGENESIS
- 4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells
- (2013) Juhee Lim et al. MOLECULES AND CELLS
- Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma
- (2013) Y. Soini et al. PATHOLOGY RESEARCH AND PRACTICE
- Therapy Response Correlates with ALDH Activity in ALDH Low-Positive Childhood Acute Lymphoblastic Leukemias
- (2013) Jörg Ahlers et al. PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Human cytochromes P450 in health and disease
- (2013) D. W. Nebert et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature
- (2013) Martin P. Barr et al. PLoS One
- SNP (–617C>A) in ARE-Like Loci of the NRF2 Gene: A New Biomarker for Prognosis of Lung Adenocarcinoma in Japanese Non-Smoking Women
- (2013) Yasuko Okano et al. PLoS One
- Expression Profile of CYP1A1 and CYP1B1 Enzymes in Colon and Bladder Tumors
- (2013) Vasilis P. Androutsopoulos et al. PLoS One
- Reversing the Intractable Nature of Pancreatic Cancer by Selectively Targeting ALDH-High, Therapy-Resistant Cancer Cells
- (2013) Sang Kyum Kim et al. PLoS One
- MRP2 (ABCC2, cMOAT) expression in nuclear envelope of primary fallopian tube cancer cells is a new unfavorable prognostic factor
- (2012) Agnieszka Halon et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition
- (2012) Woo-Kwang Jeon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance
- (2012) S. A. Rushworth et al. BLOOD
- Methylation of the KEAP1 gene promoter region in human colorectal cancer
- (2012) Naoyuki Hanada et al. BMC CANCER
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitors
- (2012) Cheng-Po Huang et al. CANCER LETTERS
- Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide
- (2012) Miran Jang et al. CANCER RESEARCH
- Oxidative Stress-Regulated Lentiviral TK/GCV Gene Therapy for Lung Cancer Treatment
- (2012) H. M. Leinonen et al. CANCER RESEARCH
- Bortezomib induces heme oxygenase-1 expression in multiple myeloma
- (2012) Lawrence N. Barrera et al. CELL CYCLE
- Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia
- (2012) Savitha Varatharajan et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Expression and function of heme oxygenase-1 in human gastric cancer
- (2012) Yujing Yin et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
- (2012) Surendra Singh et al. FREE RADICAL BIOLOGY AND MEDICINE
- Somatic mutations of the KEAP1 gene in common solid cancers
- (2012) Nam Jin Yoo et al. HISTOPATHOLOGY
- Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2)
- (2012) Wen Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells
- (2012) W. D. Kim et al. JOURNAL OF CELL SCIENCE
- Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
- (2012) Olav E. Yri et al. LEUKEMIA & LYMPHOMA
- Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
- (2012) Sadagopan Magesh et al. MEDICINAL RESEARCH REVIEWS
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis
- (2012) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Aldehyde dehydrogenase 1A1—a new mediator of resistance to temozolomide in glioblastoma
- (2012) Andrea Schäfer et al. NEURO-ONCOLOGY
- Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes
- (2012) M. L. de Groote et al. NUCLEIC ACIDS RESEARCH
- Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks
- (2012) Yosuke Hirotsu et al. NUCLEIC ACIDS RESEARCH
- The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
- (2012) J-H Kim et al. ONCOGENE
- Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
- (2012) A Arlt et al. ONCOGENE
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Metabolic approaches to overcoming chemoresistance in ovarian cancer
- (2011) Dong Hoon Suh et al. Annals of the New York Academy of Sciences
- Involvement of the aldo–keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms
- (2011) Toshiyuki Matsunaga et al. ANTI-CANCER DRUGS
- The cytoprotective role of the Keap1–Nrf2 pathway
- (2011) Liam Baird et al. ARCHIVES OF TOXICOLOGY
- NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones
- (2011) David Siegel et al. BIOCHEMICAL PHARMACOLOGY
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Estrogen and Cytochrome P450 1B1 Contribute to Both Early- and Late-Stage Head and Neck Carcinogenesis
- (2011) E. G. Shatalova et al. Cancer Prevention Research
- High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors
- (2011) S. A. Rushworth et al. CANCER RESEARCH
- Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer
- (2011) P. A. Konstantinopoulos et al. CANCER RESEARCH
- Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29
- (2011) Bettina Ebert et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
- (2011) Lucia Anna Muscarella et al. Epigenetics
- Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases
- (2011) Zhe-Sheng Chen et al. FEBS Journal
- Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
- (2011) Xiuwen Tang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Aldehyde dehydrogenases and cell proliferation
- (2011) G. Muzio et al. FREE RADICAL BIOLOGY AND MEDICINE
- Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage
- (2011) Bing Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
- (2011) Keiko Taguchi et al. GENES TO CELLS
- Predictive Value of Expression of ERCC 1 and GST-p for 5-Fluorouracil/Oxaliplatin Chemotherapy in Advanced Colorectal Cancer
- (2011) Eiji Noda et al. HEPATO-GASTROENTEROLOGY
- Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization
- (2011) Yumiko Kawai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aberrant Regulation of the MRP3 Gene in Non-small Cell Lung Carcinoma
- (2011) Christopher M. Mahaffey et al. Journal of Thoracic Oncology
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
- (2011) Adam Lister et al. Molecular Cancer
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
- (2011) Christopher C. Leonardo et al. NUTRITIONAL NEUROSCIENCE
- Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- (2011) D. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group
- (2011) Linlin Zhong et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The Role of Nrf2 and Cytoprotection in Regulating Chemotherapy Resistance of Human Leukemia Cells
- (2011) Stuart A. Rushworth et al. Cancers
- The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer
- (2010) Donna D. Zhang ANTIOXIDANTS & REDOX SIGNALING
- Immunohistochemical analysis of RNA-induced silencing complex-related proteins AGO2 and TNRC6A in prostate and esophageal cancers
- (2010) NAM JIN YOO et al. APMIS
- NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
- (2010) Albena T. Dinkova-Kostova et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): Mechanisms responsible for interindividual variation of UGT levels
- (2010) Karl Walter Bock BIOCHEMICAL PHARMACOLOGY
- Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1
- (2010) Takuya Miyazaki et al. CANCER SCIENCE
- Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
- (2010) Hironori Satoh et al. CARCINOGENESIS
- Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
- (2010) L. M. Solis et al. CLINICAL CANCER RESEARCH
- Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
- (2010) Zhanglin Ni et al. CURRENT DRUG METABOLISM
- Multiple roles of microsomal glutathione transferase 1 in cellular protection: A mechanistic study
- (2010) Katarina Johansson et al. FREE RADICAL BIOLOGY AND MEDICINE
- Carbonyl reductase 1 as a novel target of (−)-epigallocatechin gallate against hepatocellular carcinoma
- (2010) Weixue Huang et al. HEPATOLOGY
- Profiling the expression of cytochrome P450 in breast cancer
- (2010) Graeme I Murray et al. HISTOPATHOLOGY
- Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells
- (2010) Eunyoung Tak et al. JOURNAL OF HEPATOLOGY
- Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype
- (2010) Anju Singh et al. MOLECULAR CANCER THERAPEUTICS
- Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth
- (2010) P. Zhang et al. MOLECULAR CANCER THERAPEUTICS
- Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
- (2010) Deepti Malhotra et al. NUCLEIC ACIDS RESEARCH
- Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells
- (2010) Young Bin Hong et al. PANCREAS
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies
- (2009) Liangao Hu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cell
- (2009) Yan-Hong Zhang et al. CANCER LETTERS
- Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2
- (2009) Henryk Dreger et al. CARDIOVASCULAR RESEARCH
- Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer
- (2009) S. Homma et al. CLINICAL CANCER RESEARCH
- Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors
- (2009) Philip Lazarus et al. DRUG METABOLISM REVIEWS
- Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
- (2009) Hanane Akhdar et al. EUROPEAN JOURNAL OF CANCER
- Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma
- (2009) Christopher M. Mahaffey et al. FREE RADICAL BIOLOGY AND MEDICINE
- Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway
- (2009) Gi-seong Shim et al. FREE RADICAL BIOLOGY AND MEDICINE
- Overcoming Resistance to Conventional Drugs in Ewing Sarcoma and Identification of Molecular Predictors of Outcome
- (2009) Katia Scotlandi et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeted therapies for non-small cell lung cancer
- (2009) Wolfram C.M. Dempke et al. LUNG CANCER
- The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells
- (2009) Yonggang Ma et al. PHYTOTHERAPY RESEARCH
- Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
- (2009) Larry G. Higgins et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
- (2008) Rui Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Breast Cancer Resistance Protein Expression and 5-Fluorouracil Resistance
- (2008) Jian-Hui YUAN et al. BIOMEDICAL AND ENVIRONMENTAL SCIENCES
- Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice
- (2008) Dominika Nowis et al. BMC CANCER
- CYP1B1 expression is induced by docetaxel: effect on cell viability and drug resistance
- (2008) V G Martinez et al. BRITISH JOURNAL OF CANCER
- Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer
- (2008) Jianhui Yuan et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
- (2008) T. Ohta et al. CANCER RESEARCH
- Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway
- (2008) S. L. Brown et al. CANCER RESEARCH
- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
- (2008) X.-J. Wang et al. CARCINOGENESIS
- Reduction of doxorubicin and oracin and induction of carbonyl reductase in human breast carcinoma MCF-7 cells
- (2008) Martina Gavelová et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells
- (2008) Sang Kyum Kim et al. FREE RADICAL BIOLOGY AND MEDICINE
- Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer
- (2008) Tatsuhiro Shibata et al. GASTROENTEROLOGY
- Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
- (2008) Patrick L. Apopa et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Hemin reduces cellular sensitivity to imatinib and anthracyclins via Nrf2
- (2008) Tadashi Nagai et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Immunohistochemical expression of BCRP and ERCC1 in biopsy specimen predicts survival in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
- (2008) Shuji Ota et al. LUNG CANCER
- Dual roles of Nrf2 in cancer
- (2008) A LAU et al. PHARMACOLOGICAL RESEARCH
- Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck
- (2008) Patricia V. Basta et al. Cancer Detection and Prevention
- Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance
- (2007) Jeong-Min Cho et al. CANCER LETTERS
- Association of GSTP1 expression with resistance to docetaxel and paclitaxel in human breast cancers
- (2007) T. Arai et al. EJSO
- Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin
- (2007) Hak-Ryul Kim et al. LUNG CANCER
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started