Article
Chemistry, Medicinal
Juhee Park, Ga-Eun Lee, Hyung-Jung An, Cheol-Jung Lee, Eun Suh Cho, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Jin-Sung Choi, Dae Joon Kim, Jong-Soon Choi, Yong-Yeon Cho
Summary: Kaempferol targeting RSKs may be a strategy to reduce oxaliplatin-resistant colon cancer cells. The study provides evidence that molecular mechanisms for drug resistance in human cancer are crucial in overcoming this challenge.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Oncology
Dan Lin, Haiyang Zhang, Rui Liu, Ting Deng, Tao Ning, Ming Bai, Yuchong Yang, Kegan Zhu, Junyi Wang, Jingjing Duan, Shaohua Ge, Bei Sun, Guoguang Ying, Yi Ba
Summary: CPT1A expression is associated with oxaliplatin resistance in cancer cells, and silencing or inhibiting it can reverse drug resistance. The combination of oxaliplatin with CPT1A inhibition promotes apoptosis and inhibits proliferation. iRGD-modified exosomes efficiently deliver siCPT1A to suppress FAO in tumors, showing significant inhibition of CPT1A and reversing oxaliplatin resistance with high safety in vivo.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alessia Garufi, Riccardo Pettinari, Fabio Marchetti, Mara Cirone, Gabriella D'Orazi
Summary: Organometallic ruthenium (Ru)(II)-cymene complexes have potential pharmacological properties as alternative therapeutic agents. Polyphenols, such as curcumin and curcuminoids, also display beneficial properties in medicine, including chemoprevention. This study investigated the anticancer effect of a cationic Ruthenium (Ru)(II)-cymene Bisdemethoxycurcumin (Ru-bdcurc) complex, revealing that targeting the interconnection between the endoplasmic reticulum (ER)-resident chaperone GRP78/BiP and NRF2 pathways enhances the cytotoxic effect of Ru-bdcurc on colon cancer cells.
Review
Biochemistry & Molecular Biology
Giuseppina Barrera, Marie Angele Cucci, Margherita Grattarola, Chiara Dianzani, Giuliana Muzio, Stefania Pizzimenti
Summary: Chemoresistance poses a significant challenge to cancer treatment by affecting the efficacy of conventional and targeted therapies. Metabolic remodeling, particularly the control of redox status, and the upregulation of antioxidant systems contribute to cancer cell survival post-therapy. The master regulator Nrf2, along with other transcription factors, plays crucial roles in maintaining high antioxidant levels in chemoresistant cancer cells.
Article
Biochemistry & Molecular Biology
Mariko Shiraiwa, Tomoya Kitakaze, Yoko Yamashita, Yuichi Ukawa, Katsuyuki Mukai, Hitoshi Ashida
Summary: Pectolinarigenin (PG) and its glycoside pectolinarin (PN) have various health benefits and direct antioxidant activity. This study found that PG can indirectly induce the expression of antioxidant enzymes through the Nrf2/ARE pathway, thus protecting the liver from oxidative stress.
Article
Chemistry, Analytical
Fuentes-Velez Susana, Fagoonee Sharmila, Sanginario Alessandro, Gallo Valentina, Riganti Chiara, Pizzi Marco, Altruda Fiorella, Demarchi Danilo
Summary: Interest in impedance-based cellular assays is growing due to their multiple advantages, and our study demonstrates the potential of ECIS in cancer treatment decisions and early detection of chemoresistance. The analysis of impedance-based curves distinguishes between chemo-sensitive and chemo-resistant cells, and promises the study of time-dependent factors related to resistance acquisition in cells. The continuous monitoring and highthroughput early detection of drug resistance using the ECIS device presents new possibilities for cancer treatment and drug screening.
Review
Biochemistry & Molecular Biology
Teodor Paul Kacso, Renata Zahu, Alexandru Tirpe, Elina Valeria Paslari, Andreea Nutu, Ioana Berindan-Neagoe
Summary: This article discusses the mechanisms by which lncRNAs regulate ROS levels in cancer cells. Firstly, lncRNAs are involved in the coordinated antioxidant response of cancer cells through the nuclear factor like 2 pathway. Secondly, lncRNAs promote the Warburg effect in cancer cells, redirecting the cancer cell metabolism towards molecules important in oxidative stress regulation. Lastly, lncRNAs play a role in ROS-induced cancer cell apoptosis and proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Cody J. Schmidlin, Aryatara Shakya, Matthew Dodson, Eli Chapman, Donna D. Zhang
Summary: NRF2 plays a complex role in cancer by regulating genes involved in cell function and survival, and its activation mode determines its effects in cancer. The discovery of pharmacological modulators targeting NRF2 provides potential breakthroughs in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan, Amar B. Singh
Summary: Colorectal cancer (CRC) therapy faces challenges due to cancer stem cells (CSCs) resistance to chemotherapy. Inhibiting autophagy with 36-077, a potent PIK3C3/VPS34 inhibitor, shows promise in improving the efficacy of CRC therapy by targeting CSCs.
Article
Oncology
Xijia Zhu, Xishun Luo, Zhike Song, Shiyu Jiang, Xiangkai Long, Xueyuan Gao, Xinyang Xie, Laijian Zheng, Haipeng Wang
Summary: miR-188-5p enhances colon cancer cell chemosensitivity by promoting the expression of RASA1, leading to increased apoptosis and G(1)/S cell cycle arrest in oxaliplatin-resistant colon cancer cells.
Article
Biochemistry & Molecular Biology
Margherita Grattarola, Marie Angele Cucci, Antonella Roetto, Chiara Dianzani, Giuseppina Barrera, Stefania Pizzimenti
Summary: Intrinsic chemoresistance in pancreatic ductal adenocarcinoma is associated with high levels of antioxidants, upregulated Nrf2 and YAP protein expressions. Inhibiting these proteins could potentially overcome chemoresistance in PDAC.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Sha Zhou, Jianhong Peng, Liuniu Xiao, Caixia Zhou, Yujing Fang, Qingjian Ou, Jiayi Qin, Mengzhong Liu, Zhizhong Pan, Zhenlin Hou
Summary: TRIM25 is identified as an epigenetic regulator of oxaliplatin resistance in colorectal cancer patients, affecting disease-free survival and recurrence rates. Its overexpression promotes stem cell properties in CRC cells and resistance to chemotherapy. Targeting TRIM25 may be a potential strategy for managing OXA resistance in clinical practice.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yuru Shang, Xianbin Zhang, Lili Lu, Ke Jiang, Mathias Krohn, Stephanie Matschos, Christina Susanne Mullins, Brigitte Vollmar, Dietmar Zechner, Peng Gong, Michael Linnebacher
Summary: Pharmaceutical-grade human IgG was found to influence the viability of colorectal cancer cell lines and impair the anti-tumoral effects of oxaliplatin. Cancer cells express IgG receptors and accumulate human IgG intracellularly.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Maria Grazia Rossino, Rosario Amato, Marialaura Amadio, Michela Rosini, Filippo Basagni, Maurizio Cammalleri, Massimo Dal Monte, Giovanni Casini
Summary: The study found that NIH1 can enhance nuclear translocation of Nrf2, inhibit retinal damage caused by oxidative stress, and prevent apoptotic cell death and gliotic reactivity induced by oxidative stress.
Article
Biochemistry & Molecular Biology
Sun Young Park, Ye Seo Chung, So Yeon Park, So Hee Kim
Summary: Resistance to oxaliplatin in colorectal cancer cells is associated with increased phosphorylation of AMPK, leading to cell survival. Inhibition of AMPK can induce autophagy and restore chemosensitivity to anticancer drugs.
Article
Environmental Sciences
Jingwen Zhang, Huiling Cui, Akhileshwar Namani, Jun Yao, Hong Deng, Xiuwen Tang, Xiu Jun Wang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Environmental Sciences
Jingwen Zhang, Yiping Chen, Akhileshwar Namani, Mohamed Elshaer, Zhinong Jiang, Hongfei Shi, Xiuwen Tang, Xiu Jun Wang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Gastroenterology & Hepatology
Yiping Chen, Kaihua Liu, Jingwen Zhang, Yan Hai, Peng Wang, Hongyan Wang, Qiuyan Liu, Catherine C. L. Wong, Jun Yao, Yang Gao, Yijiao Liao, Xiuwen Tang, Xiu Jun Wang
Article
Cell Biology
Mohamed Elshaer, Ahmed Islam ElManawy, Ahmed Hammad, Akhileshwar Namani, Xiu Jun Wang, Xiuwen Tang
Letter
Gastroenterology & Hepatology
Xiuwen Tang, Xiu Jun Wang
Article
Oncology
Sha Huang, Tianyu He, Sijia Yang, Hongxu Sheng, Xiuwen Tang, Feichao Bao, Yiqing Wang, Xu Lin, Wenfeng Yu, Fei Cheng, Wang Lv, Jian Hu
TRANSLATIONAL LUNG CANCER RESEARCH
(2020)
Article
Oncology
Ahmed Hammad, Zhao-Hong Zheng, Akhileshwar Namani, Mohamed Elshaer, Xiu Jun Wang, Xiuwen Tang
Summary: Through global gene expression profiling, the potential role of MKP-1 in colorectal cancer (CRC) progression has been revealed, showing that the molecular processes regulated by MKP-1 are closely associated with cancer development, including cell adhesion, ion transport, extracellular matrix organization, drug response, hypoxia response, and toxic substance response. Additionally, nine hub genes associated with CRC were identified through protein-protein interaction network analysis.
Article
Gastroenterology & Hepatology
Zhi-Nong Jiang, Syed Minhaj Uddin Ahmed, Qin-Chuan Wang, Hong-Fei Shi, Xiu-Wen Tang
Summary: The study found that overexpression of NQO1 is associated with significantly poor prognosis and better response to 5-FU in gastric cancer patients. NQO1 overexpression can serve as a prominent prognostic biomarker for gastric cancer patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qinqin Cui, Wei Wang, Akhileshwar Namani, Hongyan Wang, Ahmed Hammad, Pu Huang, Yang Gao, Mohamed Elshaer, Yihe Wu, Xiu Jun Wang, Xiuwen Tang
Summary: The NRF2 signaling pathway is commonly deregulated in human cancers, and its role in RNA splicing regulation has been discovered in this study. NRF2 knockdown altered 839 alternative splicing events in 485 genes in non-small cell lung cancer cells. Mechanistically, NRF2 transcriptionally regulated SMN mRNA expression and physically associated with SMN protein. The NRF2-SMN interaction influenced RNA splicing and was associated with alterations in the NRF2 pathway in lung squamous cell carcinoma patients.
Article
Mathematical & Computational Biology
Ahmed Hammad, Mohamed Elshaer, Xiuwen Tang
Summary: This study utilized bioinformatics and machine learning to explore novel biomarkers for CRC, identifying 105 DEGs and 10 significant hub genes. Validation through ROC curve and survival analyses confirmed the potential application value of these biomarkers in CRC diagnosis and prognosis.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Oncology
Akhileshwar Namani, Zhaohong Zheng, Xiu Jun Wang, Xiuwen Tang
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)