Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

(2015) Tatsuhiro Shibata et al.   NEOPLASIA

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus

(2013) A. Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2

(2013) Hye-Youn Cho   Oxidative Medicine and Cellular Longevity

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of Keap1-Nrf2 System in Upper Aerodigestive Tract Carcinogenesis

(2012) A. Ohkoshi et al.   Cancer Prevention Research

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

(2012) Daisuke Inoue et al.   CANCER SCIENCE

Kinetic Analyses of Keap1-Nrf2 Interaction and Determination of the Minimal Nrf2 Peptide Sequence Required for Keap1 Binding Using Surface Plasmon Resonance

(2011) Yu Chen et al.   Chemical Biology & Drug Design

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Mutation of the Nrf2 gene in non-small cell lung cancer

(2011) Yi Hu et al.   MOLECULAR BIOLOGY REPORTS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Gain of Nrf2 Function in Non-Small-Cell Lung Cancer Cells Confers Radioresistance

(2010) Anju Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

The Critical Role of Nitric Oxide Signaling, via ProteinS-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response

(2010) Shigemoto Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer

(2010) Tsuyoshi Takahashi et al.   JOURNAL OF SURGICAL ONCOLOGY

NFE2L2 Gene Mutation in Male Japanese Squamous Cell Carcinoma of the Lung

(2010) Hidefumi Sasaki et al.   Journal of Thoracic Oncology

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

(2010) T. Ogura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

(2009) Suryakant K. Niture et al.   JOURNAL OF CELL SCIENCE

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1

(2008) Balasundaram Padmanabhan et al.   JOURNAL OF SYNCHROTRON RADIATION

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA