The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
出版年份 2020 全文链接
标题
The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors
作者
关键词
-
出版物
Oxidative Medicine and Cellular Longevity
Volume 2020, Issue -, Pages 1-14
出版商
Hindawi Limited
发表日期
2020-12-23
DOI
10.1155/2020/8810785
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling
- (2020) Divya Venkatesh et al. GENES & DEVELOPMENT
- Energy-stress-mediated AMPK activation inhibits ferroptosis
- (2020) Hyemin Lee et al. NATURE CELL BIOLOGY
- Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
- (2020) Yilong Zou et al. Nature Chemical Biology
- DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
- (2020) Ji Cao et al. Nature Communications
- TLR2 Signaling Pathway Combats Streptococcus uberis Infection by Inducing Mitochondrial Reactive Oxygen Species Production
- (2020) Bin Li et al. Cells
- Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- (2020) Yolanda Augustin et al. PHARMACOLOGY & THERAPEUTICS
- NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway
- (2020) Pengfei Liu et al. Redox Biology
- Targeting Metabolic–Redox Circuits for Cancer Therapy
- (2019) Kui Wang et al. TRENDS IN BIOCHEMICAL SCIENCES
- Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells
- (2019) Andy Göbel et al. Cell Death & Disease
- Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1
- (2019) Yilei Zhang et al. CELL CYCLE
- The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11
- (2019) Tong Liu et al. CANCER RESEARCH
- Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- (2019) Guo-Qing Chen et al. CELL DEATH AND DIFFERENTIATION
- CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
- (2019) Weimin Wang et al. NATURE
- ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
- (2019) Bo Chu et al. NATURE CELL BIOLOGY
- ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–
- (2019) Liyuan Wang et al. CELL DEATH AND DIFFERENTIATION
- Targeting ferroptosis in rhabdomyosarcoma cells
- (2019) Jasmin Dächert et al. INTERNATIONAL JOURNAL OF CANCER
- Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
- (2019) Jiao Wu et al. NATURE
- A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
- (2019) Yilong Zou et al. Nature Communications
- Acetaminophen sensitizing erastin‐induced ferroptosis via modulation of Nrf2/heme oxygenase‐1 signaling pathway in non‐small‐cell lung cancer
- (2019) Chengcheng Gai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin
- (2019) Xuefei Zhang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
- (2019) Gloria E. Villalpando-Rodriguez et al. Oxidative Medicine and Cellular Longevity
- Metadherin enhances vulnerability of cancer cells to ferroptosis
- (2019) Jianling Bi et al. Cell Death & Disease
- Inactivation of the glutathione peroxidase GPx4 by the ferroptosis‐inducing molecule RSL3 requires the adaptor protein 14‐3‐3ε
- (2019) Ana‐Marija Vučković et al. FEBS LETTERS
- Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1
- (2019) Hironari Nishizawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyrotinib versus lapatinib in HER2-positive breast cancer
- (2019) Elizabeth Gourd LANCET ONCOLOGY
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis
- (2019) Tian-Xiang Wang et al. Cell Death & Disease
- Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells
- (2019) Hai Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
- (2019) Kewen Hu et al. JOURNAL OF CLINICAL INVESTIGATION
- Nrf2-Keap1 signaling in oxidative and reductive stress
- (2018) Ilaria Bellezza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Ferroptosis: A Novel Anti-tumor Action for Cisplatin
- (2018) Jipeng Guo et al. Cancer Research and Treatment
- p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
- (2018) Amy Tarangelo et al. Cell Reports
- The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis
- (2018) Keerthana Gnanapradeepan et al. Frontiers in Endocrinology
- AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
- (2018) Xinxin Song et al. CURRENT BIOLOGY
- BAP1 links metabolic regulation of ferroptosis to tumour suppression
- (2018) Yilei Zhang et al. NATURE CELL BIOLOGY
- Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma
- (2018) Derek Lee et al. HEPATOLOGY
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- The α6β4 integrin promotes resistance to ferroptosis
- (2017) Caitlin W. Brown et al. JOURNAL OF CELL BIOLOGY
- Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2
- (2017) Xiaoyan Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away?
- (2017) William M. Lee JOURNAL OF HEPATOLOGY
- NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
- (2017) Delin Chen et al. MOLECULAR CELL
- NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
- (2017) Samantha W. Alvarez et al. NATURE
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy
- (2017) Thomas Efferth SEMINARS IN CANCER BIOLOGY
- The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
- (2017) Chun-Shik Shin et al. Nature Communications
- Cisplatin is retained in the cochlea indefinitely following chemotherapy
- (2017) Andrew M. Breglio et al. Nature Communications
- Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation
- (2017) David S. Liu et al. Nature Communications
- EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes
- (2017) Yiqun Jiang et al. Theranostics
- Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine
- (2017) Ioannis Poursaitidis et al. Cell Reports
- ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival
- (2017) Gary X. Wang et al. Cell Reports
- The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
- (2017) Yangchun Xie et al. Cell Reports
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
- (2017) Jong-Lyel Roh et al. Redox Biology
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Identification of ACSL4 as a biomarker and contributor of ferroptosis
- (2016) Hua Yuan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Toxicological properties of fenugreek (Trigonella foenum graecum)
- (2016) Mounir Ouzir et al. FOOD AND CHEMICAL TOXICOLOGY
- An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model
- (2016) Matthew Jennis et al. GENES & DEVELOPMENT
- Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis
- (2016) Xiaofang Sun et al. HEPATOLOGY
- Glutathione peroxidase 4: a new player in neurodegeneration?
- (2016) B R Cardoso et al. MOLECULAR PSYCHIATRY
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses
- (2016) Yang Ou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells
- (2016) S Ma et al. Cell Death & Disease
- Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression
- (2016) Shang-Jui Wang et al. Cell Reports
- Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential
- (2016) Kuo Du et al. Redox Biology
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- (2015) Scott J. Dixon et al. ACS Chemical Biology
- Preclinical activity of the repurposed drug auranofin in classical Hodgkin lymphoma
- (2015) M. Celegato et al. BLOOD
- The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
- (2015) Christophe Louandre et al. CANCER LETTERS
- Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses
- (2015) Le Jiang et al. CELL CYCLE
- Chemical biology of anticancer gold(iii) and gold(i) complexes
- (2015) Taotao Zou et al. CHEMICAL SOCIETY REVIEWS
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Ferroptosis as a p53-mediated activity during tumour suppression
- (2015) Le Jiang et al. NATURE
- Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress
- (2015) Eric Habib et al. Redox Biology
- Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation
- (2014) Marie Stampe Ostenfeld et al. Autophagy
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Cellular mechanisms and physiological consequences of redox-dependent signalling
- (2014) Kira M. Holmström et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Glutathione and mitochondria
- (2014) Vicent Ribas et al. Frontiers in Pharmacology
- Modulation of oxidative stress as an anticancer strategy
- (2013) Chiara Gorrini et al. NATURE REVIEWS DRUG DISCOVERY
- Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway
- (2013) Michelle R. Campbell et al. Oxidative Medicine and Cellular Longevity
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Mutant p53R273Hattenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species
- (2012) Eyal Kalo et al. JOURNAL OF CELL SCIENCE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
- (2011) Keiko Taguchi et al. GENES TO CELLS
- Mechanisms of Cell Protection by Heme Oxygenase-1
- (2010) Raffaella Gozzelino et al. Annual Review of Pharmacology and Toxicology
- LSH and G9a/GLP complex are required for developmentally programmed DNA methylation
- (2010) K. Myant et al. GENOME RESEARCH
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Association of reactive oxygen species levels and radioresistance in cancer stem cells
- (2009) Maximilian Diehn et al. NATURE
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
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