Review
Oncology
Giorgia Centonze, Dora Natalini, Alessio Piccolantonio, Vincenzo Salemme, Alessandro Morellato, Pietro Arina, Chiara Riganti, Paola Defilippi
Summary: Cholesterol plays a dual role in breast cancer, promoting cell migration and metastasis formation while reducing the permeability of chemotherapeutics. Low vitamin D levels are associated with an increased risk of breast cancer, and overexpression of steroid hormones and their receptors contribute to breast cancer progression. Cholesterol targeting drugs show promise as tools for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tabea Jahn, Christopher Clark, Anja Kerksiek, Piotr Lewczuk, Dieter Luetjohann, Julius Popp
Summary: This study demonstrates the association of non-cholesterol sterols and oxysterols in the central nervous system with Alzheimer's disease and core AD biomarkers, suggesting they may represent potential intervention targets to slow down disease progression.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: Oxysterols are believed to contribute to the development of cardiovascular diseases, and their serum levels are positively associated with cholesterol absorption and synthesis. However, the regulation of different oxysterols in the body is largely unknown. This study aimed to investigate the relationship between clinical factors and cholesterol metabolism markers, as well as identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease.
Article
Multidisciplinary Sciences
Clint M. Upchurch, Scott Yeudall, Caitlin M. Pavelec, Dennis Merk, Jan Greulich, Mohan Manjegowda, Shyam S. Raghavan, Irina M. Bochkis, Michael M. Scott, Edward Perez-Reyes, Norbert Leitinger
Summary: This study demonstrates the protective and preventive effects of an antibody against oxidized phosphatidylcholines (OxPCs) at different stages of nonalcoholic fatty liver disease (NAFLD). It provides evidence that individual OxPC species independently affect disease initiation and progression, and that adeno-associated virus (AAV)-mediated expression of the antibody is an effective therapeutic intervention.
Article
Endocrinology & Metabolism
Yan Fan, Long-Teng Yan, Zheng Yao, Guang-Yi Xiong
Summary: The study showed that BCA treatment effectively improved NAFLD in rats by reducing liver index and improving pathological changes, while also regulating lipid metabolism indexes and gene expressions related to lipid metabolism.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Nathaniel L. Baker, Samar M. Hammad, Kelly J. Hunt, Andrea Semler, Richard L. Klein, Maria F. Lopes-Virella
Summary: This study found that plasma apoM levels are associated with the development of diabetic kidney disease. Higher apoM levels are associated with increased risk of progression to macroalbuminuria and chronic kidney disease in patients with type 1 diabetes, suggesting that alterations in apoM may play a role in the development of nephropathy.
Review
Agriculture, Multidisciplinary
Fan Zhang, Junhua Li, Cuihua Chang, Luping Gu, Wen Xiong, Yujie Su, Yanjun Yang
Summary: This review discusses the contradictory conclusions about the relationship between egg consumption and cardiovascular disease (CVD) risk, as well as the effects of egg cholesterol intake on cholesterol homeostasis. The study finds that moderate egg consumption has no substantial overall impact on cholesterol homeostasis in healthy individuals. However, excessive cholesterol intake is not recommended for individuals with metabolic disorders. In the future, the impact of egg consumption on CVD risk should be considered from different perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Leire Goicoechea, Laura Conde de la Rosa, Sandra Torres, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa
Summary: Cholesterol is a crucial component of cell membrane bilayers and has important physiological roles in mitochondria and its metabolism. Excessive mitochondrial cholesterol can lead to oxidative stress, cell death, and the development of various diseases.
Article
Multidisciplinary Sciences
Kathrin Beyer, Stein Atle Lie, Bodil Bjorndal, Rolf K. Berge, Asbjorn Svardal, Johan G. Brun, Anne Isine Bolstad
Summary: This study explored alterations in lipid, fatty acid, and carnitine- and choline derivative profiles in RA patients with different degrees of periodontal inflammation. Findings included higher lipid and fatty acid concentrations in active RA, possibly related to prednisolone medication. The results may support interdisciplinary collaboration to improve personalized treatment for patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nuria Lopez-Alcantara, Rebecca Oelkrug, Sarah Christine Sentis, Henriette Kirchner, Jens Mittag
Summary: This study reveals the reduced expression of TR(3) during the progression of NASH, indicating the development of thyroid hormone resistance. Surprisingly, increasing TR(3) expression does not improve NASH pathology, gene expression, or metabolic parameters in mice. The study suggests that liver-targeted approaches may be more relevant for NASH treatment with thyroid hormone receptor agonists.
Article
Food Science & Technology
Suraphan Panyod, Wei-Kai Wu, Sin-Yi Peng, Yea-Jing Tseng, Ya-Chi Hsieh, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Hsiao-Li Chuang, Cheng-Chih Hsu, Ting-Chin David Shen, Kai-Chien Yang, Chi-Tang Ho, Ming-Shiang Wu, Lee-Yan Sheen
Summary: Recently, the role of gut microbiota in diseases, including cardiovascular disease, has gained research attention. Ginger essential oil (GEO) and its bioactive compound citral have shown anti-atherosclerotic effects by improving lipid profile, blood sugar, insulin resistance, and reducing TMAO levels and inflammatory cytokines. They also modulate gut microbiota diversity and composition.
NPJ SCIENCE OF FOOD
(2023)
Article
Biochemistry & Molecular Biology
Qin Luo, Jingfei Chen, Yingjie Su, Panyun Wu, Jiangang Wang, Zhenfei Fang, Fei Luo
Summary: This study investigated the relationship between serum sASGR1 concentration and LDL-C levels, and found a positive correlation between them. Furthermore, the effect of serum sASGR1 on LDL-C levels was significantly influenced by hypertension status. LDL-C and white blood cell count were identified as independent influencing factors for serum sASGR1 levels.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Neurosciences
Giovanni Palermo, Sara Giannoni, Martina Giuntini, Elisabetta Belli, Daniela Frosini, Gabriele Siciliano, Roberto Ceravolo
Summary: The study found that long-term statin use in patients with Parkinson's disease can slow down the progression of motor impairment, especially after 4 years. Statin treatment also resulted in a slower progression of the rigidity score of UPDRS compared to non-users.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Oncology
Aino Siltari, Heimo Syvala, Yan-Ru Lou, Yuan Gao, Teemu J. Murtola
Summary: Lipid metabolism plays a crucial role in the development and progression of prostate cancer, interacting with androgens and immune cells. Understanding the modulation of lipid metabolism is important in explaining the limited efficacy of immune-oncological treatments in prostate cancer.
Article
Cell Biology
Ke Lu, Tian-Shu Shi, Si-Yu Shen, Yong Shi, Hong-Liang Gao, Jing Wu, Xiang Lu, Xiang Gao, Huang-Xian Ju, Wei Wang, Yi Cao, Di Chen, Chao-Jun Li, Bin Xue, Qing Jiang
Summary: Hepatic osteodystrophy (HOD) is a metabolic bone disease associated with chronic liver disease. Upregulation of the phosphatase PP2Aca in the liver during HOD leads to downregulation of hepatokine lecithin-cholesterol acyltransferase (LCAT). Loss of LCAT function exacerbates bone loss in HOD mice. Cholesterol levels play a role in the regulation of osteoblast and osteoclast activities. LCAT improves liver function and reduces liver fibrosis in the HOD mouse model by promoting cholesterol transport from bone to liver.
Article
Clinical Neurology
Cristina M. Gaudioso, Soe Mar, T. Charles Casper, Rachel Codden, Adam Nguyen, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Carla Francisco, Mark P. Gorman, Manu S. Goyal, Jennifer Graves, Benjamin M. Greenberg, Janace Hart, Lauren Krupp, Timothy Lotze, Sona Narula, Sean J. Pittock, Mary Rensel, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, Yolanda Wheeler, Emmanuelle Waubant, Eoin P. Flanagan
Summary: This study aims to determine the frequency of MOG-IgG and AQP4-IgG in pediatric-onset multiple sclerosis (POMS) patients and healthy controls, evaluate the fulfillment of diagnostic criteria in seropositive cases, compare characteristics and outcomes between POMS and MOGAD, and identify clinical features associated with final diagnosis.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Lauren B. Krupp, Emmanuelle Waubant, Michael Waltz, T. Charles Casper, Anita Belman, Yolanda Wheeler, Jayne Ness, Jennifer Graves, Mark Gorman, Leslie Benson, Soe Mar, Manu Goyal, Teri Schreiner, Bianca Weinstock-Guttman, Moses Rodriguez, Jan-Mendelt Tillema, Timothy Lotze, Greg Aaen, Mary Rensel, John Rose, Tanuja Chitinis, Allan George, Leigh E. Charvet
Summary: The cognitive differences between pediatric and adult multiple sclerosis (MS) are not well understood. This study compared cognitive performances in pediatric MS, adult MS, and pediatric healthy controls, and found that pediatric MS patients perform better than adults with MS on cognitive screens.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Dejan Jakimovski, Katelyn S. Kavak, Karen Zakalik, Timothy Coetzee, Malcolm Gottesman, Patricia K. Coyle, Robert Zivadinov, Bianca Weinstock-Guttman
Summary: Judicious diagnosis and early treatment of multiple sclerosis (MS) can significantly improve long-term disability outcomes. A retrospective analysis based on 25 years of data showed that changes in diagnostic criteria can shorten the time between symptom onset and MS diagnosis. Further improvements and implementation of MS diagnostic criteria may reduce the diagnosis lag.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Niels Bergsland, Michael G. Dwyer, Dejan Jakimovski, Eleonora Tavazzi, Ralph H. B. Benedict, Bianca Weinstock-Guttman, Robert Zivadinov
Summary: This study found a correlation between increased volume and inflammation of the choroid plexus (CP) and clinical disability progression in patients with multiple sclerosis (MS).
Article
Neurosciences
Ibrahim Abdollahpour, Yahya Salimi, Saharnaz Nedjat, Maryam Nazemipour, Mohammad Ali Mansournia, Bianca Weinstock-Guttman
Summary: The study found that there is an additive interaction between Dietary Inflammatory Index (DII) and drug abuse, gender, and history of depression in multiple sclerosis (MS). However, there is no evidence of multiplicative interaction between DII and other risk factors of MS.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Immunology
Dejan Jakimovski, Svetlana P. Eckert, Omid Mirmosayyeb, Sangharsha Thapa, Penny Pennington, David Hojnacki, Bianca Weinstock-Guttman
Summary: This study aimed to determine the real-world efficacy of tixagevimab and cilgavimab (Evusheld (TM)) in preventing breakthrough COVID-19 infections in immunosuppressed persons with neuroinflammatory diseases (pwNID). The results showed that pwNID treated with tixagevimab and cilgavimab had a significantly lower rate of COVID-19 infections and milder severity compared to the control group.
Article
Medicine, General & Internal
Nicholas Young, Robert Zivadinov, Michael G. Dwyer, Niels Bergsland, Bianca Weinstock-Guttman, Dejan Jakimovski
Summary: This study found that people with multiple sclerosis (pwMS) have fewer retinal blood vessels compared to healthy controls (HCs). Over time, pwMS experience a decrease in retinal vessel number while HCs experience an increase. Furthermore, there is a correlation between lower RNFL thickness and fewer retinal vessel number and smaller diameter in pwMS.
Article
Clinical Neurology
Jack A. Reeves, Zachary Weinstock, Robert Zivadinov, Michael G. Dwyer, Niels Bergsland, Fahad Salman, Ferdinand Schweser, Bianca Weinstock-Guttman, Ralph H. B. Benedict, Dejan Jakimovski
Summary: This study found that patients with relapsing-remitting multiple sclerosis (pwRRMS) who experienced relapse had higher prevalence of paramagnetic rim lesions (PRL) and worse cognitive recovery compared to stable controls.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Dejan Jakimovski, Diego Silva, Niels Bergsland, Michael G. Dwyer, Bianca Weinstock-Guttman, Ralph H. B. Benedict, Jon Riolo, Robert Zivadinov
Summary: In this study, artificial intelligence-based volumetric analysis was used to investigate the effect of disease modifying therapies (DMTs) on brain atrophy in multiple sclerosis (MS) patients. The results showed that untreated patients had greater brain atrophy changes compared to treated patients, especially those receiving high-efficacy DMTs. Patients who stopped DMTs during follow-up also showed increased brain atrophy. The study demonstrates the potential of using T2-FLAIR scans to detect treatment-induced neurodegenerative changes in a real-world clinical setting.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Caila B. Vaughn, Katelyn S. Kavak, Dejan Jakimovski, Natasha Qutab, Robin Avila, Megan Vignos, Bianca Weinstock-Guttman
Summary: A large retrospective study found that patient-reported limitations in physical and mental symptoms can predict future disability worsening in multiple sclerosis (MS) patients treated with intramuscular interferon-beta medication. The study also identified lower extremities limitations and fatigue as the most predictive factors for disability worsening.
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Article
Clinical Neurology
Dejan Jakimovski, Ferhan Qureshi, Murali Ramanathan, Victor Gehman, Anisha Keshavan, Kelly Leyden, Michael G. Dwyer, Niels Bergsland, Bianca Weinstock-Guttman, Robert Zivadinov
Summary: Blood-based biomarkers can be used as economic and easily accessible tools for monitoring and predicting disease activity in multiple sclerosis. This study found that a multivariate proteomic assay can predict concurrent and future microstructural brain pathology in people with multiple sclerosis. Glial fibrillary acidic protein was the most common and highest-ranked biomarker associated with central nervous system alterations. Higher levels of glial fibrillary acidic protein were also predictive of more severe axonal damage and disability progression.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Dejan Jakimovski, Taylor R. Wicks, Niels Bergsland, Michael G. Dwyer, Bianca Weinstock-Guttman, Robert Zivadinov
Summary: This study found that patient-reported outcomes (PROs) are associated with concurrent and future impairments in persons with multiple sclerosis (pwMS). The structural and pathological relationships with PROs in pwMS have not been elucidated.
DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE
(2023)
