The Impact of the ‘Mis-Peptidome’ on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection

(2020) Bernhard Loll et al.   Frontiers in Immunology

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

(2020) Louise C. Rowntree et al.   Frontiers in Immunology

Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

(2020) Liye Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2)

(2020) Elena Lorente et al.   MOLECULAR & CELLULAR PROTEOMICS

The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease

(2020) Fabiana Paladini et al.   Frontiers in Immunology

Peptide trimming by endoplasmic reticulum aminopeptidases: Role of MHC class I binding and ERAP dimerization

(2019) Irini Evnouchidou et al.   HUMAN IMMUNOLOGY

Redundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behçet’s Disease-Associated HLA-B*51 Peptidome.

(2019) Pablo Guasp et al.   MOLECULAR & CELLULAR PROTEOMICS

Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype

(2019) Ronja Driller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The rs75862629 minor allele in the endoplasmic reticulum aminopeptidases intergenic region affects human leucocyte antigen B27 expression and protects from ankylosing spondylitis in Sardinia

(2019) Fabiana Paladini et al.   RHEUMATOLOGY

Unusual Placement of an EBV Epitope into the Groove of the Ankylosing Spondylitis-Associated HLA-B27 Allele Allows CD8+ T Cell Activation

(2019) Valentina Tedeschi et al.   Cells

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition

(2019) Jian Yin et al.   ANNALS OF THE RHEUMATIC DISEASES

Allele-specific alterations in the peptidome underlie the joint association of HLA-A*29:02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy

(2018) Alejandro Sanz-Bravo et al.   MOLECULAR & CELLULAR PROTEOMICS

The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position

(2018) Shira Yair-Sabag et al.   PROTEOMICS

Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis

(2018) Jörg Christoph Prinz   Frontiers in Immunology

The role of HLA-B*27 in spondyloarthritis

(2018) Robert A. Colbert et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The role of polymorphic ERAP1 in autoinflammatory disease

(2018) Emma Reeves et al.   BIOSCIENCE REPORTS

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis

(2018) Jonas J W Kuiper, Jessica van Setten, Matthew Devall, Mircea Cretu-Stancu, Sanne Hiddingh, Roel A Ophoff, Tom O A R Missotten, Mirjam van Velthoven et al.   HUMAN MOLECULAR GENETICS

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes

(2018) Fabiana Paladini et al.   Scientific Reports

How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins

(2018) José A. López de Castro   Frontiers in Immunology

Genetics and Functional Genomics of Spondyloarthritis

(2018) Félicie Costantino et al.   Frontiers in Immunology

Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes

(2017) Judilyn Fuentes-Duculan et al.   EXPERIMENTAL DERMATOLOGY

Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction

(2017) Jennifer G. Abelin et al.   IMMUNITY

The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule

(2017) Jesse I. Mobbs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing

(2017) Pablo Guasp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices

(2017) Moreno Di Marco et al.   JOURNAL OF IMMUNOLOGY

The Human Leukocyte Antigen (HLA)-B27 Peptidomein Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion

(2017) Eilon Barnea et al.   MOLECULAR & CELLULAR PROTEOMICS

HLA Class I or Class II and Disease Association: Catch the Difference If You Can

(2017) Maria Teresa Fiorillo et al.   Frontiers in Immunology

Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury

(2016) Ling-juan Zhang et al.   IMMUNITY

The Ankylosing Spondylitis-Associated HLA-B*2705 Presents a B*0702-Restricted EBV Epitope and Sustains the Clonal Amplification of Cytotoxic T Cells in Patients

(2016) Valentina Tedeschi et al.   MOLECULAR MEDICINE

Functional Interaction of the Ankylosing Spondylitis-Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA-B*27 Peptidome in Human Cells

(2016) Adrian Martín-Esteban et al.   Arthritis & Rheumatology

The Peptidome of Behçet's Disease-Associated HLA-B*51:01 Includes Two Subpeptidomes Differentially Shaped by Endoplasmic Reticulum Aminopeptidase 1

(2016) Pablo Guasp et al.   Arthritis & Rheumatology

ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis

(2015) Liye Chen et al.   ANNALS OF THE RHEUMATIC DISEASES

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease

(2015) Michael J. Ombrello et al.   CURRENT OPINION IN RHEUMATOLOGY

Melanocyte antigen triggers autoimmunity in human psoriasis

(2015) Akiko Arakawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen

(2015) Carlos Alvarez-Navarro et al.   MOLECULAR & CELLULAR PROTEOMICS

'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease

(2015) Dennis McGonagle et al.   Nature Reviews Rheumatology

The immunopathogenesis of birdshot chorioretinopathy; a bird of many feathers

(2015) Jonas Kuiper et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Revisiting the Arthritogenic Peptide Theory: Quantitative Not Qualitative Changes in the Peptide Repertoire of HLA-B27 Allotypes

(2015) Ralf B. Schittenhelm et al.   Arthritis & Rheumatology

Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

(2015) Mary-Ellen Costello et al.   Arthritis & Rheumatology

Behçet’s Disease: Do Natural Killer Cells Play a Significant Role?

(2015) Harry Petrushkin et al.   Frontiers in Immunology

THU0223 Genetics of behçet’s disease in sardinia: two distinct extended hla haplotypes harbor the B*51 allele in normal population and in patients

(2014) M. Piga et al.   ANNALS OF THE RHEUMATIC DISEASES

Detection of choroid- and retina-antigen reactive CD8+ and CD4+ T lymphocytes in the vitreous fluid of patients with birdshot chorioretinopathy

(2014) Jonas J.W. Kuiper et al.   HUMAN IMMUNOLOGY

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy

(2014) Jonas J.W. Kuiper et al.   HUMAN MOLECULAR GENETICS

Peptide Handling by HLA-B27 Subtypes Influences Their Biological Behavior, Association with Ankylosing Spondylitis and Susceptibility to Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

(2014) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

Behcet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity

(2014) M. J. Ombrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

(2014) Roberto Lande et al.   Nature Communications

HLA-B27-mediated protection in HIV and hepatitis C virus infection and pathogenesis in spondyloarthritis

(2013) Christoph Neumann-Haefelin   CURRENT OPINION IN RHEUMATOLOGY

Natural HLA-B*2705 Protein Ligands with Glutamine as Anchor Motif

(2013) Susana Infantes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

(2013) E. Zervoudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27

(2013) Liye Chen et al.   Arthritis & Rheumatology

Abacavir induces loading of novel self-peptides into HLA-B*57

(2012) Michael A. Norcross et al.   AIDS

Characterization of a Proteasome and TAP-independent Presentation of Intracellular Epitopes by HLA-B27 Molecules

(2012) Adriana Magnacca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

(2012) Patricia T. Illing et al.   NATURE

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

(2012) D. A. Ostrov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Susceptibility to ankylosing spondylitis but not disease outcome is influenced by the level of HLA-B27 expression, which shows moderate variability over time

(2012) A Cauli et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Old and new HLA associations with ankylosing spondylitis

(2012) R. Díaz-Peña et al.   TISSUE ANTIGENS

IL-17A Upregulates Keratin 17 Expression in Keratinocytes through STAT1- and STAT3-Dependent Mechanisms

(2011) Xiaowei Shi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dynamical Characterization of Two Differentially Disease Associated MHC Class I Proteins in Complex with Viral and Self-Peptides

(2011) Daniele Narzi et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

HLA-B*51 and Behçet Disease

(2011) Ahmet Gul et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

The HLA-B2705 peptidome

(2010) Lilach Halevi et al.   ARTHRITIS AND RHEUMATISM

HLA-B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility

(2010) Heinz Fabian et al.   ARTHRITIS AND RHEUMATISM

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

HLA‑B27 misfolding and spondyloarthropathies

(2010) Robert A. Colbert et al.   Prion

The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding

(2010) A. Van Hateren et al.   TISSUE ANTIGENS

Azathioprine in severe uveitis of Behçet's disease

(2010) D. Saadoun et al.   ARTHRITIS CARE & RESEARCH

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE