Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders

(2017) Tsewang Tashi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetics of human origin and evolution: high-altitude adaptations

(2016) Abigail W Bigham   CURRENT OPINION IN GENETICS & DEVELOPMENT

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Ubiquitin-mediated proteolysis in Xenopus extract

(2016) Gary S. McDowell et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Active DNA demethylation at enhancers during the vertebrate phylotypic period

(2016) Ozren Bogdanović et al.   NATURE GENETICS

TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management

(2016) Bernard Thienpont et al.   Epigenomics

The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

(2016) Jinjin Xu et al.   Nature Communications

K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression

(2016) Han-Tsang Wu et al.   Nature Communications

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes

(2016) Shih-Han Kao et al.   Journal of Clinical Medicine

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

(2015) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

(2015) T. Bishop et al.   CIRCULATION RESEARCH

Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation

(2015) Xing Liu et al.   NUCLEIC ACIDS RESEARCH

Regulation of carotid body oxygen sensing by hypoxia-inducible factors

(2015) Nanduri R. Prabhakar et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence

(2015) Cheng Li et al.   Cell Reports

Human high-altitude adaptation: forward genetics meets the HIF pathway

(2014) Abigail W. Bigham et al.   GENES & DEVELOPMENT

Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia

(2014) Xiao Gou et al.   GENOME RESEARCH

Defective Tibetan PHD2 Binding to p23 Links High Altitude Adaption to Altered Oxygen Sensing

(2014) Daisheng Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Von Hippel-Lindau Protein Suppresses Androgen Receptor Activity

(2014) Jing Wang et al.   MOLECULAR ENDOCRINOLOGY

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA

(2014) Emilia Huerta-Sánchez et al.   NATURE

A genetic mechanism for Tibetan high-altitude adaptation

(2014) Felipe R Lorenzo et al.   NATURE GENETICS

TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

(2014) Christopher J. Mariani et al.   Cell Reports

Hypoxia Adaptations in the Grey Wolf (Canis lupus chanco) from Qinghai-Tibet Plateau

(2014) Wenping Zhang et al.   PLoS Genetics

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Ubiquitin-independent proteasomal degradation

(2013) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Efficient identification of TALEN-mediated genome modifications using heteroduplex mobility assays

(2013) Satoshi Ota et al.   GENES TO CELLS

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

(2011) Meelad M. Dawlaty et al.   Cell Stem Cell

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

(2011) H. Wu et al.   GENES & DEVELOPMENT

Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

(2011) Natacha Le Moan et al.   MOLECULAR CELL

Ubiquitin-Independent Degradation of Antiapoptotic MCL-1

(2010) D. P. Stewart et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

U19/Eaf2 Binds to and Stabilizes von Hippel-Lindau Protein

(2009) W. Xiao et al.   CANCER RESEARCH

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism