Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

(2017) Paola Falletta et al.   GENES & DEVELOPMENT

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

PARP1 orchestrates epigenetic events setting up chromatin domains

(2017) Fabio Ciccarone et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate–Lactate Exchange in BRAF-Mutant Human Melanoma Cells

(2016) Teresa Delgado-Goni et al.   MOLECULAR CANCER THERAPEUTICS

NAD+ salvage pathway in cancer metabolism and therapy

(2016) Barry E. Kennedy et al.   PHARMACOLOGICAL RESEARCH

Melanoma driver mutations and immune therapy

(2016) Douglas B. Johnson et al.   OncoImmunology

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

(2015) Kensuke Tateishi et al.   CANCER CELL

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

(2015) Willy Hugo et al.   CELL

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Sirtuins in Epigenetic Regulation

(2015) Hui Jing et al.   CHEMICAL REVIEWS

Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism

(2015) Marcus J. Miller et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

(2015) Franziska Baenke et al.   Molecular Oncology

Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma

(2015) Ambra A. Grolla et al.   Pigment Cell & Melanoma Research

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

(2015) Annelien Verfaillie et al.   Nature Communications

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment

(2015) Stefanie Riesenberg et al.   Nature Communications

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

(2015) Patrick Laurette et al.   eLife

TheNAMPTPromoter Is Regulated by Mechanical Stress, Signal Transducer and Activator of Transcription 5, and Acute Respiratory Distress Syndrome–Associated Genetic Variants

(2014) Xiaoguang Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCR  Locus in Response to IL-7R Signaling

(2014) K. Maki et al.   JOURNAL OF IMMUNOLOGY

CtBP and Associated LSD1 Are Required for Transcriptional Activation by NeuroD1 in Gastrointestinal Endocrine Cells

(2014) S. K. Ray et al.   MOLECULAR AND CELLULAR BIOLOGY

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

(2014) Judith Müller et al.   Nature Communications

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

(2014) T. J. Parmenter et al.   Cancer Discovery

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

PARP-1 Regulates Metastatic Melanoma through Modulation of Vimentin-induced Malignant Transformation

(2013) María Isabel Rodríguez et al.   PLoS Genetics

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

Aurora B Is Regulated by the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (MAPK/ERK) Signaling Pathway and Is a Valuable Potential Target in Melanoma Cells

(2012) Caroline Bonet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nicotinamide phosphoribosyltransferase (NAMPT) is over-expressed in melanoma lesions

(2012) Elena Maldi et al.   Pigment Cell & Melanoma Research

FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973

(2012) Andreas R Baudy et al.   EJNMMI Research

Noninvasive genomic detection of melanoma

(2011) W. Wachsman et al.   BRITISH JOURNAL OF DERMATOLOGY

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

CtBP2 Downregulation during Neural Crest Specification Induces Expression of Mitf and REST, Resulting in Melanocyte Differentiation and Sympathoadrenal Lineage Suppression

(2011) H. Liang et al.   MOLECULAR AND CELLULAR BIOLOGY

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

STAT5 Is Critical To Maintain Effector CD8+ T Cell Responses

(2010) P. Tripathi et al.   JOURNAL OF IMMUNOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

seqMINER: an integrated ChIP-seq data interpretation platform

(2010) Tao Ye et al.   NUCLEIC ACIDS RESEARCH

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

(2009) Anne M. Evans et al.   ANALYTICAL CHEMISTRY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

(2009) Anne von Heideman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States

(2008) K. S. Hoek et al.   CANCER RESEARCH

STAT5 contributes to antiapoptosis in melanoma

(2008) Jessica C. Hassel et al.   MELANOMA RESEARCH

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY

IGF1 Promotes Resistance to Apoptosis in Melanoma Cells through an Increased Expression of BCL2, BCL-X(L), and Survivin

(2007) Caroline Hilmi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY