期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 173, 期 14, 页码 2182-2194出版社
WILEY
DOI: 10.1111/bph.13505
关键词
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资金
- Leonino Fontana and Maria Lionello FIRC fellowship [14832]
- AIRC grant, San Paolo
- Dipartimento di Scienze del Farmaco, Universita del Piemonte Orientale, Novara, Italy
- Biotechnology and Biological Sciences Research Council [JF16994] Funding Source: researchfish
- British Heart Foundation [PG/10/38/28359] Funding Source: researchfish
In this review, we focus on the secreted form of nicotinamide phosphoribosyltransferase (NAMPT); extracellular NAMPT (eNAMPT), also known as pre-B cell colony-enhancing factor or visfatin. Although intracellular NAMPT is a key enzyme in controlling NAD metabolism, eNAMPT has been reported to function as a cytokine, with many roles in physiology and pathology. Circulating eNAMPT has been associated with several metabolic and inflammatory disorders, including cancer. Because cytokines produced in the tumour micro-environment play an important role in cancer pathogenesis, in part by reprogramming cellular metabolism, future improvements in cancer immunotherapy will require a better understanding of the crosstalk between cytokine action and tumour biology. In this review, the knowledge of eNAMPT in cancer will be discussed, focusing on its immunometabolic function as a metabokine, its secretion, its mechanism of action and possible roles in the cancer micro-environment.
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