Histone Deacetylase Sirtuin 1 Deacetylates IRF1 Protein and Programs Dendritic Cells to Control Th17 Protein Differentiation during Autoimmune Inflammation

IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

(2015) Fabrizio Mattei et al.   NEOPLASIA

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

The Serine-threonine Kinase Inositol-requiring Enzyme 1α (IRE1α) Promotes IL-4 Production in T Helper Cells

(2013) Kyeorda L. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecules Altering the Intracellular Thiol Content Modulate NF-kB and STAT-1/IRF-1 Signalling Pathways and IL-12 p40 and IL-27 p28 Production in Murine Macrophages

(2013) Alessandra Fraternale et al.   PLoS One

Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1

(2013) Ting Zou et al.   PLoS One

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation

(2012) Gonghua Huang et al.   NATURE IMMUNOLOGY

Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance

(2012) B. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation

(2011) Sinyi Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR2-Mediated Production of IL-27 and Chemokines by Respiratory Epithelial Cells Promotes Bleomycin-Induced Pulmonary Fibrosis in Mice

(2011) Hye Sung Kim et al.   JOURNAL OF IMMUNOLOGY

c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation

(2011) A. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression

(2011) S. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Activation of IL-27p28Gene Transcription by Interferon Regulatory Factor 8 in Cooperation with Interferon Regulatory Factor 1

(2010) Jidong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-27 promotes T cell–dependent colitis through multiple mechanisms

(2010) Jennifer H. Cox et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical Role of the IFN-Stimulated Gene Factor 3 Complex in TLR-Mediated IL-27p28 Gene Expression Revealing a Two-Step Activation Process

(2010) Céline Molle et al.   JOURNAL OF IMMUNOLOGY

Differential Requirement of Histone Acetylase and Deacetylase Activities for IRF5-Mediated Proinflammatory Cytokine Expression

(2010) D. Feng et al.   JOURNAL OF IMMUNOLOGY

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Sirtuin-1 regulation of mammalian metabolism

(2010) Matthew P. Gillum et al.   TRENDS IN MOLECULAR MEDICINE

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

(2009) A. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1

(2008) S.-M. Lee et al.   BLOOD

sirt1-null mice develop an autoimmune-like condition

(2008) Jedon Sequeira et al.   EXPERIMENTAL CELL RESEARCH

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY