New insights in acetaminophen toxicity: HMGB1 contributes by itself to amplify hepatocyte necrosis in vitro through the TLR4-TRIF-RIPK3 axis

506 – Combination of Glycyrrhizin and N-Acetylcysteine : Benefit Outcome in a Murine Model of Acetaminophen-Induced Liver Failure

(2019) Charlotte Minsart et al.   GASTROENTEROLOGY

Mo1430 - Hepatocyte Release of HMGB1 During Acetaminophen-Induced Liver Injury and Deleterious Feed-Forward Process: Implication of Necroptosis Through TRIF/RIPK3 Axis

(2018) Charlotte Minsart et al.   GASTROENTEROLOGY

Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing

(2016) Kennon Heard et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Receptor interacting protein kinase 1 (RIPK1) in hepatocytes does not mediate murine acetaminophen toxicity

(2015) Anne T. Schneider et al.   HEPATOLOGY

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

(2015) Lily Dara et al.   HEPATOLOGY

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans

(2014) C. David Williams et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury

(2014) J-X Li et al.   Cell Death & Disease

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lessons from look-back in acute liver failure? A single centre experience of 3300 patients

(2013) William Bernal et al.   JOURNAL OF HEPATOLOGY

Toll Like Receptor 3 Plays a Critical Role in the Progression and Severity of Acetaminophen-Induced Hepatotoxicity

(2013) Karen A. Cavassani et al.   PLoS One

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations

(2012) Laura P. James et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Dendritic cell depletion exacerbates acetaminophen hepatotoxicity

(2011) Michael K. Connolly et al.   HEPATOLOGY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

Circulating apoptotic and necrotic cell death markers in patients with acute liver injury

(2011) Darren G. N. Craig et al.   LIVER INTERNATIONAL

Acute liver failure in Scotland between 1992 and 2009; incidence, aetiology and outcome

(2011) A. D. Bretherick et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Macrophage activation by factors released from acetaminophen-injured hepatocytes: Potential role of HMGB1

(2011) Ana-Cristina Dragomir et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Protective Effect of High-Mobility Group Box 1 Blockade on Acute Liver Failure in Rats

(2010) Kiminori Takano et al.   SHOCK

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology