标题
Allosteric inhibition of antiapoptotic MCL-1
作者
关键词
-
出版物
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 6, Pages 600-607
出版商
Springer Nature
发表日期
2016-05-10
DOI
10.1038/nsmb.3223
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Design of Covalent Allosteric Drugs
- (2015) Ruth Nussinov et al. Annual Review of Pharmacology and Toxicology
- Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design
- (2015) Jason P. Burke et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity
- (2015) Milan Bruncko et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism
- (2015) Lauren A. Barclay et al. MOLECULAR CELL
- Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
- (2015) J D Leverson et al. Cell Death & Disease
- Chemistry: Chemical con artists foil drug discovery
- (2014) Jonathan Baell et al. NATURE
- High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design
- (2014) Gaohua Liu et al. PLoS One
- Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
- (2014) Li Tan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties
- (2013) Xiangguo (Eric) Shi et al. ANALYTICAL CHEMISTRY
- Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor
- (2013) Sang Min Lim et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Multimodal Interaction with BCL-2 Family Proteins Underlies the Proapoptotic Activity of PUMA BH3
- (2013) Amanda L. Edwards et al. CHEMISTRY & BIOLOGY
- Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
- (2013) X. Wang et al. GENES & DEVELOPMENT
- Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
- (2013) G. Madhavi Sastry et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
- (2013) Jonathan M. Ostrem et al. NATURE
- PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis
- (2013) Ariele Viacava Follis et al. Nature Chemical Biology
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Direct activation of full-length proapoptotic BAK
- (2013) Elizaveta S. Leshchiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival
- (2012) Nicole A. Cohen et al. CHEMISTRY & BIOLOGY
- Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors
- (2012) Yiyu Ge et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
- (2012) Anders Friberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mcl-1 regulates the survival of adult neural precursor cells
- (2012) Craig D. Malone et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Inhibition of DNA binding activity of cAMP response element-binding protein by 1,2-naphthoquinone through chemical modification of Cys-286
- (2011) Akiko Endo et al. CHEMICO-BIOLOGICAL INTERACTIONS
- BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore
- (2011) Loren D. Walensky et al. TRENDS IN BIOCHEMICAL SCIENCES
- Probing theα-Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis
- (2010) Zuojun Guo et al. Chemical Biology & Drug Design
- Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome
- (2010) Craig R. Braun et al. CHEMISTRY & BIOLOGY
- Ubiquitin-Independent Degradation of Antiapoptotic MCL-1
- (2010) D. P. Stewart et al. MOLECULAR AND CELLULAR BIOLOGY
- BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
- (2010) Evripidis Gavathiotis et al. MOLECULAR CELL
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
- (2010) Michelle L Stewart et al. Nature Chemical Biology
- Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS
- (2009) John R. Engen ANALYTICAL CHEMISTRY
- Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
- (2009) Erinna F. Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
- (2009) Wenjun Zhou et al. NATURE
- BAX activation is initiated at a novel interaction site
- (2008) Evripidis Gavathiotis et al. NATURE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now