标题
Cancer regeneration: Polyploid cells are the key drivers of tumor progression
作者
关键词
Cancer stem cell, Polyploidy, Malignancy, Multinucleation, Regeneration
出版物
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1874, Issue 2, Pages 188408
出版商
Elsevier BV
发表日期
2020-08-20
DOI
10.1016/j.bbcan.2020.188408
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Intratumor Heterogeneity and Therapy Resistance: Contributions of Dormancy, Apoptosis Reversal (Anastasis) and Cell Fusion to Disease Recurrence
- (2020) Razmik Mirzayans et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury
- (2019) Patrick D. Wilkinson et al. AMERICAN JOURNAL OF PATHOLOGY
- Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer
- (2019) Junsong Chen et al. CURRENT CANCER DRUG TARGETS
- Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP
- (2019) Raj Pranap Arun et al. Scientific Reports
- The “life code”: a theory that unifies the human life cycle and the origin of human tumors
- (2019) Liu Jinsong SEMINARS IN CANCER BIOLOGY
- In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration
- (2019) Tomonori Matsumoto et al. Cell Stem Cell
- A Distinct Oncogenerative Multinucleated Cancer Cell Serves as a Source of Stemness and Tumor Heterogeneity
- (2018) David Díaz-Carballo et al. CANCER RESEARCH
- Polyploidy in tissue homeostasis and regeneration
- (2018) Jan Inge Øvrebø et al. DEVELOPMENT
- The Polyploid State Plays a Tumor-Suppressive Role in the Liver
- (2018) Shuyuan Zhang et al. DEVELOPMENTAL CELL
- Generation of erythroid cells from polyploid giant cancer cells: re-thinking about tumor blood supply
- (2018) Zhigang Yang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Chromothripsis in acute myeloid leukemia: biological features and impact on survival
- (2018) Maria Chiara Fontana et al. LEUKEMIA
- Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers
- (2018) Masanori Kawakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Dualistic Origin of Human Tumors
- (2018) Jinsong Liu SEMINARS IN CANCER BIOLOGY
- Reversine, a substituted purine, exerts an inhibitive effect on human renal carcinoma cells via induction of cell apoptosis and polyploidy
- (2018) Li Cheng et al. OncoTargets and Therapy
- Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
- (2018) Elena Lazzeri et al. Nature Communications
- Mammalian Cells Undergo Endoreduplication in Response to Lactic Acidosis
- (2018) Zhihao Tan et al. Scientific Reports
- Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization
- (2018) Yiu To Yeung et al. EBioMedicine
- Chromothripsis in Hepatocarcinogenesis: The Role of a Micronuclear Aberration and Polyploidy
- (2018) I. V. Uryvaeva et al. BIOLOGY BULLETIN
- The polyploid state restricts hepatocyte proliferation and liver regeneration
- (2018) Patrick D Wilkinson et al. HEPATOLOGY
- Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut
- (2018) Erez Cohen et al. eLife
- Solving the Polyploid Mystery in Health and Disease
- (2018) K.J. Gjelsvik et al. TRENDS IN GENETICS
- Molecular features unique to glioblastoma radiation resistant residual cells may affect patient outcome - a short report
- (2018) Ekjot Kaur et al. CELLULAR ONCOLOGY
- Whole genome duplication is an early event leading to aneuploidy in IDH-wild type glioblastoma
- (2018) Blandine Boisselier et al. Oncotarget
- Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma
- (2018) Shariful Islam et al. Oncotarget
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- The evolutionary significance of polyploidy
- (2017) Yves Van de Peer et al. NATURE REVIEWS GENETICS
- Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells
- (2017) N Niu et al. ONCOGENE
- Belinostat and vincristine demonstrate mutually synergistic cytotoxicity associated with mitotic arrest and inhibition of polyploidy in a preclinical model of aggressive diffuse large B cell lymphoma
- (2016) Aaron P. Havas et al. CANCER BIOLOGY & THERAPY
- A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
- (2016) Faiyaz Notta et al. NATURE
- Essential role for a novel population of binucleated mammary epithelial cells in lactation
- (2016) Anne C. Rios et al. Nature Communications
- Linking genomic reorganization to tumor initiation via the giant cell cycle
- (2016) N Niu et al. Oncogenesis
- Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells
- (2016) Eike-Benjamin Braune et al. Stem Cell Reports
- Wound-Induced Polyploidy Is Required for Tissue Repair
- (2016) Vicki P. Losick Advances in Wound Care
- Multinucleation Is an Objective Feature Useful in the Diagnosis of Pleomorphic Lobular Carcinoma In Situ
- (2015) Luis Z. Blanco et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Docetaxel-induced polyploidization may underlie chemoresistance and disease relapse
- (2015) Angela Ogden et al. CANCER LETTERS
- Multinucleation and Mesenchymal-to-Epithelial Transition Alleviate Resistance to Combined Cabazitaxel and Antiandrogen Therapy in Advanced Prostate Cancer
- (2015) S. K. Martin et al. CANCER RESEARCH
- Tetraploidy and CIN: a dangerous combination
- (2015) Sally Dewhurst et al. CELL CYCLE
- Polyploidy and genome evolution in plants
- (2015) Pamela S Soltis et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts
- (2015) Noriko Takegahara et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The expanding implications of polyploidy
- (2015) Kevin P. Schoenfelder et al. JOURNAL OF CELL BIOLOGY
- Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease
- (2015) Géraldine Gentric et al. JOURNAL OF CLINICAL INVESTIGATION
- Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer
- (2015) A. Choudhary et al. MOLECULAR CANCER THERAPEUTICS
- A cell-based model system links chromothripsis with hyperploidy
- (2015) B. R. Mardin et al. Molecular Systems Biology
- Polyploidy can drive rapid adaptation in yeast
- (2015) Anna M. Selmecki et al. NATURE
- When bigger is better: the role of polyploidy in organogenesis
- (2015) Terry L. Orr-Weaver TRENDS IN GENETICS
- In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells
- (2015) C Leikam et al. Cell Death & Disease
- Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells
- (2015) Weihua Zhou et al. Oncotarget
- Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence
- (2015) Grazyna Mosieniak et al. NEOPLASIA
- Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors
- (2014) Prudence Donovan et al. Molecular BioSystems
- Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics
- (2014) Sharad Sharma et al. Molecular Oncology
- CoCl2, a Mimic of Hypoxia, Induces Formation of Polyploid Giant Cells with Stem Characteristics in Colon Cancer
- (2014) Laura M. Lopez-Sánchez et al. PLoS One
- Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention
- (2014) D. Lissa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution
- (2014) S. M. Dewhurst et al. Cancer Discovery
- Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer
- (2014) Jermaine Coward et al. Frontiers in Oncology
- Generation of erythroid cells from fibroblasts and cancer cells in vitro and in vivo
- (2013) Shiwu Zhang et al. CANCER LETTERS
- Polyploidization and Cell Fusion Contribute to Wound Healing in the Adult Drosophila Epithelium
- (2013) Vicki P. Losick et al. CURRENT BIOLOGY
- Tissue Repair through Cell Competition and Compensatory Cellular Hypertrophy in Postmitotic Epithelia
- (2013) Yoichiro Tamori et al. DEVELOPMENTAL CELL
- Robust cellular reprogramming occurs spontaneously during liver regeneration
- (2013) K. Yanger et al. GENES & DEVELOPMENT
- Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel
- (2013) Shiwu Zhang et al. INTERNATIONAL JOURNAL OF CANCER
- Number of glioma polyploid giant cancer cells (PGCCs) associated with vasculogenic mimicry formation and tumor grade in human glioma
- (2013) Yang Qu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inhibition of mTOR Pathway Sensitizes Acute Myeloid Leukemia Cells to Aurora Inhibitors by Suppression of Glycolytic Metabolism
- (2013) L.-L. Liu et al. MOLECULAR CANCER RESEARCH
- Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
- (2013) S. Sharma et al. MOLECULAR CANCER THERAPEUTICS
- Pan-cancer patterns of somatic copy number alteration
- (2013) Travis I Zack et al. NATURE GENETICS
- Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
- (2013) S Zhang et al. ONCOGENE
- Intratumour Diversity of Chromosome Copy Numbers in Neuroblastoma Mediated by On-Going Chromosome Loss from a Polyploid State
- (2013) Gisela Lundberg et al. PLoS One
- iTRAQ-Based Proteomic Analysis of Polyploid Giant Cancer Cells and Budding Progeny Cells Reveals Several Distinct Pathways for Ovarian Cancer Development
- (2013) Shiwu Zhang et al. PLoS One
- Aneuploidy, polyploidy and ploidy reversal in the liver
- (2013) Andrew W. Duncan SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Isolation, Characterization, and Transplantation of Bone Marrow-Derived Cell Components with Hematopoietic Stem Cell Niche Properties
- (2013) Naser Ahmadbeigi et al. STEM CELLS AND DEVELOPMENT
- To divide or not to divide: revisiting liver regeneration
- (2013) Yuichiro Miyaoka et al. Cell Division
- Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations
- (2013) Shang-Lin Chang et al. PLoS Genetics
- Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells
- (2012) Lizhou Jia et al. CANCER LETTERS
- Tetraploid cells from cytokinesis failure induce aneuploidy and spontaneous transformation of mouse ovarian surface epithelial cells
- (2012) Lei Lv et al. CELL CYCLE
- Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy
- (2012) A Ogden et al. CELL DEATH AND DIFFERENTIATION
- Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration
- (2012) Yuichiro Miyaoka et al. CURRENT BIOLOGY
- The aggregate nature of human mesenchymal stromal cells in native bone marrow
- (2012) Naser Ahmadbeigi et al. CYTOTHERAPY
- Aneuploidy as a mechanism for stress-induced liver adaptation
- (2012) Andrew W. Duncan et al. JOURNAL OF CLINICAL INVESTIGATION
- Radiation-Induced Reprogramming of Breast Cancer Cells
- (2012) Chann Lagadec et al. STEM CELLS
- Reversine induces cell cycle arrest, polyploidy, and apoptosis in human breast cancer cells
- (2012) Chin-Ho Kuo et al. Breast Cancer
- Formation of solid tumors by a single multinucleated cancer cell
- (2011) Zhang Weihua et al. CANCER
- Adaptation of Saccharomyces cerevisiae to saline stress through laboratory evolution
- (2011) R. DHAR et al. JOURNAL OF EVOLUTIONARY BIOLOGY
- Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy
- (2011) Patricia Balsas et al. LEUKEMIA RESEARCH
- Entosis: aneuploidy by invasion
- (2011) Aniek Janssen et al. NATURE CELL BIOLOGY
- Regulation of Cardiomyocyte Polyploidy and Multinucleation by CyclinG1
- (2010) Zhipei Liu et al. CIRCULATION RESEARCH
- Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells
- (2010) Kristine Salmina et al. EXPERIMENTAL CELL RESEARCH
- Somatic polyploidy promotes cell function under stress and energy depletion: evidence from tissue-specific mammal transcriptome
- (2010) Olga V. Anatskaya et al. FUNCTIONAL & INTEGRATIVE GENOMICS
- Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?
- (2010) A. A. Dar et al. MOLECULAR CANCER THERAPEUTICS
- The ploidy conveyor of mature hepatocytes as a source of genetic variation
- (2010) Andrew W. Duncan et al. NATURE
- A Mitosis Block Links Active Cell Cycle with Human Epidermal Differentiation and Results in Endoreplication
- (2010) Jennifer Zanet et al. PLoS One
- Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase
- (2009) Nica M. Borradaile et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells
- (2009) Sylvia Mansilla et al. BIOCHEMICAL PHARMACOLOGY
- Activation of Meiosis-Specific Genes Is Associated with Depolyploidization of Human Tumor Cells following Radiation-Induced Mitotic Catastrophe
- (2009) F. Ianzini et al. CANCER RESEARCH
- Development and function of trophoblast giant cells in the rodent placenta
- (2009) Dong Hu et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor
- (2008) Giulia Rancati et al. CELL
- Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy
- (2008) Pierre-Emmanuel Puig et al. CELL BIOLOGY INTERNATIONAL
- Aneuploid mosaicism in the developing and adult cerebellar cortex
- (2008) Jurjen W. Westra et al. JOURNAL OF COMPARATIVE NEUROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More