TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis

A Stem Cell Approach to Cure Type 1 Diabetes

(2020) Aharon Helman et al.   Cold Spring Harbor Perspectives in Biology

Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications

(2020) Dawit Zewdu Wondafrash et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

(2020) Dan Wang et al.   CELL

Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice

(2020) Kristina G. Maxwell et al.   Science Translational Medicine

Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action

(2020) Lance A. Thielen et al.   Cell Metabolism

Immune-evasive human islet-like organoids ameliorate diabetes

(2020) Eiji Yoshihara et al.   NATURE

Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation

(2019) Lingling Xu et al.   Oxidative Medicine and Cellular Longevity

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy

(2019) Shan Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells

(2019) Gaelle Filhoulaud et al.   Frontiers in Endocrinology

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

(2019) Po-Chun Tseng et al.   Frontiers in Immunology

Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes

(2019) Cristiane Lumi Hirata et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Silencing of TXNIP Alleviated Oxidative Stress Injury by Regulating MAPK–Nrf2 Axis in Ischemic Stroke

(2019) Yu Tian et al.   NEUROCHEMICAL RESEARCH

Rapid and persistent loss of TXNIP in HT22 neuronal cells under carbonyl and hyperosmotic stress

(2019) Alcir Luiz Dafre et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis

(2018) Jialiang Duan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

(2018) Di Chen et al.   Journal of Neuroinflammation

Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction

(2018) Ming Wu et al.   LABORATORY INVESTIGATION

Verapamil and beta cell function in adults with recent-onset type 1 diabetes

(2018) Fernando Ovalle et al.   NATURE MEDICINE

Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway

(2018) Mariarosa Anna. Beatrice Melone et al.   PHARMACEUTICAL RESEARCH

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms

(2018) Madhura Panse et al.   PLoS One

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

(2018) Fumiaki Ohtake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes pathogenic mechanisms and potential new therapies based upon a novel target called TXNIP

(2018) Lance Thielen et al.   Current Opinion in Endocrinology Diabetes and Obesity

TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress

(2018) Hangsak Huy et al.   AGING CELL

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

(2018) William J. Sullivan et al.   CELL

Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats

(2018) Marcin Gamdzyk et al.   NEUROPHARMACOLOGY

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways

(2018) Feng Zhou et al.   Frontiers in Endocrinology

Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide

(2017) Seong-Jeong Han et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons

(2017) Marco Antonio Zaragoza-Campillo et al.   Oxidative Medicine and Cellular Longevity

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

(2017) Clare F. Malone et al.   Cancer Discovery

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

(2017) Althea N. Waldhart et al.   Cell Reports

TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling

(2016) Junqin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein

(2016) Shin Yee Hong et al.   CELLULAR SIGNALLING

Structural basis for a novel interaction between TXNIP and Vav2

(2016) Shasha Liu et al.   FEBS LETTERS

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline

(2016) Wei Chen et al.   INFLAMMATION RESEARCH

CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury

(2016) Lei Jiang et al.   INFLAMMATION RESEARCH

Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease

(2016) Chunyang Du et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes

(2016) Xiao-Feng Li et al.   JOINT BONE SPINE

Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways

(2016) Kyunghee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential expression of thioredoxin binding protein-2/Txnip in human placenta: Possible involvement of hypoxia in its suppression during early pregnancy

(2016) Haruta Mogami et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

(2016) Hong Feng et al.   Journal of Diabetes Research

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats

(2016) Chunchun Ding et al.   Scientific Reports

TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells

(2016) Hisa Hui Ling Tseng et al.   Scientific Reports

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells

(2015) Udayakumar Karunakaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cellsviaactivating ROS-TXNIP-NLRP3 inflammasome

(2015) Wei Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium

(2015) Yan Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

(2015) Yi Li et al.   PHARMACOLOGICAL RESEARCH

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction

(2015) Akram Sadeghirizi et al.   TUMOR BIOLOGY

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells

(2014) Jianjun Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1

(2014) Ulla Schwertassek et al.   FEBS Journal

Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway

(2014) Jia Xiao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

(2014) Justine M. Abais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-200 Is Induced by Thioredoxin-interacting Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis

(2014) Stephen R. Filios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-interacting Protein Promotes Islet Amyloid Polypeptide Expression through miR-124a and FoxA2

(2014) Gu Jing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Metabolomics Connects Thioredoxin-interacting Protein (TXNIP) to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle

(2014) Karen L. DeBalsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats

(2014) Qing-Yu Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

MondoA-Mlx Transcriptional Activity Is Limited by mTOR-MondoA Interaction

(2014) Mohan R. Kaadige et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases

(2014) Eiji Yoshihara et al.   Frontiers in Immunology

Thioredoxin-Interacting Protein Expression Is Required for VEGF-Mediated Angiogenic Signal in Endothelial Cells

(2013) Mohammed A. Abdelsaid et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia

(2013) Regina Wanju Wong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TXNIP interacts with hEcd to increase p53 stability and activity

(2013) Hyun-Woo Suh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801

(2013) Fuminori Yamaguchi et al.   BMC CANCER

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action

(2013) Jonathan E. Campbell et al.   Cell Metabolism

Txnip contributes to impaired glucose tolerance by upregulating the expression of genes involved in hepatic gluconeogenesis in mice

(2013) Seong Ho Jo et al.   DIABETOLOGIA

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

(2013) Ning Wu et al.   MOLECULAR CELL

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204

(2013) Guanlan Xu et al.   NATURE MEDICINE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

(2013) Young-Jun Park et al.   PLoS Pathogens

Thioredoxin System in Cell Death Progression

(2012) Jun Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

TXNIP Switches Tracks toward a Terminal UPR

(2012) Tracy G. Anthony et al.   Cell Metabolism

Preventing  -Cell Loss and Diabetes With Calcium Channel Blockers

(2012) G. Xu et al.   DIABETES

Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death

(2012) E. Reich et al.   DIABETOLOGIA

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

TXNIP in Agrp Neurons Regulates Adiposity, Energy Expenditure, and Central Leptin Sensitivity

(2012) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

Deficiency of Thioredoxin Binding Protein-2 (TBP-2) Enhances TGF-β Signaling and Promotes Epithelial to Mesenchymal Transition

(2012) So Masaki et al.   PLoS One

An expanded family of arrestins regulate metabolism

(2012) Parth Patwari et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Thioredoxin-interacting protein suppresses bladder carcinogenesis

(2011) Koji Nishizawa et al.   CARCINOGENESIS

The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure

(2011) Parth Patwari et al.   Cell Metabolism

Thioredoxin Regulates Adipogenesis through Thioredoxin-interacting Protein (Txnip) Protein Stability

(2011) William A. Chutkow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi FujiiThioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus

(2011) Hiroshi Masutani et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury

(2011) Jun Yoshioka et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrient-Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice

(2011) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

Thioredoxin binding protein-2 mediates metabolic adaptation in response to lipopolysaccharide in vivo

(2010) Shin-ichi Oka et al.   CRITICAL CARE MEDICINE

Deletion of the  -Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

(2010) W. A. Chutkow et al.   DIABETES

Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity

(2010) Michael R. Farrell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in glucocorticoid signaling of HTLV-I-transformed T cells

(2010) Zhe Chen et al.   IMMUNOLOGY LETTERS

The Ubiquitin Ligase Itch Regulates Apoptosis by Targeting Thioredoxin-interacting Protein for Ubiquitin-dependent Degradation

(2010) Pingzhao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation

(2010) Z Chen et al.   LEUKEMIA

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity

(2010) Eiji Yoshihara et al.   Nature Communications

High β-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice

(2009) Elodie Masson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein

(2009) Junqin Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance

(2009) Bing Luan et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Identification of Thioredoxin-Interacting Protein 1 as a Hypoxia-Inducible Factor 1α-Induced Gene in Pancreatic Cancer

(2009) Amanda F. Baker et al.   PANCREAS

Lack of TXNIP protects β-cells against glucotoxicity: Figure 1

(2008) Anath Shalev   BIOCHEMICAL SOCIETY TRANSACTIONS

On the origins of arrestin and rhodopsin

(2008) Carlos E Alvarez   BMC EVOLUTIONARY BIOLOGY

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

Thioredoxin Binding Protein-2/Thioredoxin-Interacting Protein Is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator-Activated Receptor Function

(2008) Shin-ichi Oka et al.   ENDOCRINOLOGY

Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses

(2008) Aoi Son et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

(2008) Junqin Chen et al.   FASEB JOURNAL

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

(2008) S. T. Y. Hui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

(2008) C. A. Stoltzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells

(2007) Jianyong Wang et al.   NEUROCHEMISTRY INTERNATIONAL