Article
Cell Biology
Yiting Chen, Xueping Feng, Yuhao Yuan, Jiahui Jiang, Peihe Zhang, Bin Zhang
Summary: This study reveals the potential molecular mechanism of Thioredoxin-interacting protein (TXNIP) in the chemoresistance of triple-negative breast cancer (TNBC) for the first time. TXNIP inhibits the proliferation of TNBC drug-resistant cells and increases DNA damage accumulation, thereby reducing chemotherapy resistance. Furthermore, the small molecule c-Myc inhibitor 10058-F4 enhances TXNIP expression, promotes reactive oxygen species (ROS) synthesis, and enhances the cytotoxicity of chemotherapy drugs.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Yuting Guo, Juan Chen, Nan Liu, Zheng Liu, Bimin Shi, Hong Sun
Summary: Circulating TXNIP levels are positively associated with the severity of NAFLD among patients with type 2 diabetes mellitus. TXNIP may serve as a promising biomarker for NAFLD, offering an efficient way to evaluate and monitor fatty liver progression.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jung-Hwa Han, Dae-Hwan Nam, Seon-Hui Kim, Ae-Rang Hwang, So-Young Park, Jae Hyang Lim, Chang-Hoon Woo
Summary: TXNIP is a critical regulator of glucose homeostasis, fatty acid synthesis, and cholesterol accumulation in the liver, and its inhibition by CHIP can alleviate ER stress and inflammation in NAFLD. CHIP serves as a potential therapeutic target for liver diseases.
Review
Medicine, General & Internal
Melvin R. R. Hayden
Summary: Metabolic syndrome (MetS) is a global metabolic disorder that is increasing in prevalence and is closely linked to the increasing rates of obesity. It consists of a cluster of risk factors, including obesity, hyperlipidemia, hyperinsulinemia, hypertension, and hyperglycemia. These risk factors are associated with insulin resistance (IR) and are known to increase the risk for developing cerebrocardiovascular disease and type 2 diabetes mellitus. Despite name changes and the addition of new variables over the years, MetS has remained as the recognized term for this syndrome worldwide for the past three decades.
MEDICINA-LITHUANIA
(2023)
Review
Endocrinology & Metabolism
Georgia Xourafa, Melis Korbmacher, Michael Roden
Summary: This narrative Review examines the role of tissue-specific messenger systems in the development and progression of type 2 diabetes mellitus (T2DM) and its complications. It also explores the potential of biomarkers and multi-omics techniques in predicting disease risk and progression.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Rina Matsuol, Tomohiro Imamura, Ayako Takamori, Takuya Kishi, Miwako Minami, Junko Miyakawal, Natsuki Yoshitakel, Ai Hayashil, Yuki Nakayamal, Natsumi Egashiral, Minako Teramotol, Hiroko Ishinaril, Itsuka Kajiyamal, Satomi Fujisakil, Hitomi Kakiyamal, Kanako Satoul, Rei Nakafusal, Chika Tanakal, Megumi Tanakal, Yuki Isomural, Kenichi Izumi, Shoichiro Ohta, Nobuya Souta, Norihito Matsuo, Kyosuke Yamamoto, Sadatoshi Tsuji, Tsukuru Umemura, Kuniyasu Takagi, Kazuma Fujimoto
Summary: We conducted a retrospective case-control study to evaluate the effectiveness of personalized health guidance interventions provided by public health nurses for individuals with type 2 diabetes mellitus and obesity. The intervention resulted in improvements in various health indicators in subjects without pharmacotherapy, but not in the control group who did not receive any health guidance. However, the therapeutic effects of health guidance were observed in cases where pharmacotherapy was administered. Overall, individual health guidance interventions may be effective for individuals with type 2 diabetes mellitus and obesity who regularly attend medical checkups.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2023)
Article
Obstetrics & Gynecology
Haruta Mogami, Shigeo Yura, Eiji Kondoh, Hiroshi Masutani, Junji Yodoi, Ikuo Konishi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Zong Wei, Eiji Yoshihara, Nanhai He, Nasun Hah, Weiwei Fan, Antonio F. M. Pinto, Timothy Huddy, Yuhao Wang, Brittany Ross, Gabriela Estepa, Yang Dai, Ning Ding, Mara H. Sherman, Sungsoon Fang, Xuan Zhao, Christopher Liddle, Annette R. Atkins, Ruth T. Yu, Michael Downes, Ronald M. Evans
Article
Cell Biology
Maryam Ahmadian, Sihao Liu, Shannon M. Reilly, Nasun Hah, Weiwei Fan, Eiji Yoshihara, Pooja Jha, C. Daniel De Magalhaes Filho, Sandra Jacinto, Andrew V. Gomez, Yang Dai, Ruth T. Yu, Christopher Liddle, Annette R. Atkins, Johan Auwerx, Alan R. Saltiel, Michael Downes, Ronald M. Evans
Article
Biochemistry & Molecular Biology
Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu, Tong Zhang, Mathias Leblanc, Sihao Liu, Mingxiao He, Wanda Waizenegger, Emanuel Gasser, Bernd Schnabl, Annette R. Atkins, Ruth T. Yu, Rob Knight, Christopher Liddle, Michael Downes, Ronald M. Evans
Article
Biochemistry & Molecular Biology
Cristiane Lumi Hirata, Shinji Ito, Hiroshi Masutani
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
Mina Noura, Hidemasa Matsuo, Asami Koyama, Souichi Adachi, Hiroshi Masutani
Article
Multidisciplinary Sciences
Eiji Yoshihara, Carolyn O'Connor, Emanuel Gasser, Zong Wei, Tae Gyu Oh, Tiffany W. Tseng, Dan Wang, Fritz Cayabyab, Yang Dai, Ruth T. Yu, Christopher Liddle, Annette R. Atkins, Michael Downes, Ronald M. Evans
Review
Biochemistry & Molecular Biology
Eiji Yoshihara
Article
Biochemistry & Molecular Biology
Hiroshi Masutani
Summary: Thioredoxin-interacting protein (Txnip) is a critical cancer suppressor and regulator of energy metabolism; the mechanism of action of Txnip remains to be fully elucidated and requires further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Masaki Iwamoto, Takahiro Masuya, Mari Hosose, Koki Tagawa, Tomoka Ishibashi, Keitaro Suyama, Takeru Nose, Eiji Yoshihara, Michael Downes, Ronald M. Evans, Ayami Matsushima
Summary: Bisphenol derivatives were found to act as coactivator-binding inhibitors (CBIs) affecting ERβ signaling, providing critical insights for future drug development based on ER signaling and revealing their potential as endocrine disruptors.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Fritz Cayabyab, Lina R. Nih, Eiji Yoshihara
Summary: Diabetes is a complex global disease affecting over 400 million people, with pancreatic islet transplantation showing promise in treating type 1 diabetes but facing challenges such as immune rejection. Current research focuses on finding optimal transplantation sites and methods to improve islet graft survival, with the aim of translating these studies into successful clinical therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Meghan Tahbaz, Eiji Yoshihara
Summary: Insulin injection and human pancreatic islet transplantation are current main therapies for T1D or late-stage severe T2D, but limitations such as islet shortage and immunosuppression side effects call for the need to develop novel methods for generating protected functional human islets. Human pluripotent stem cells offer a potentially limitless cell source, and studying immune tolerance induction in hPSC-derived human pancreatic islets contributes to the goal of curing insulin-dependent diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
William T. Cefalu, Dana K. Andersen, Guillermo Arreaza-Rubin, Christopher L. Pin, Sheryl Sato, C. Bruce Verchere, Minna Woo, Norman D. Rosenblum
Summary: This article summarizes the proceedings of an international symposium held by Canadian and American health research institutions, discussing new directions in diabetes research and treatment, as well as the heterogeneity of diabetes and the prospects for precision medicine.
Article
Gastroenterology & Hepatology
Jinhyuk Choi, Tae Gyu Oh, Hee-Won Jung, Kun-Young Park, Hyemi Shin, Taehee Jo, Du-Seock Kang, Dipanjan Chanda, Sujung Hong, Jina Kim, Hayoung Hwang, Moongi Ji, Minkyo Jung, Takashi Shoji, Ayami Matsushima, Pilhan Kim, Ji Young Mun, Man-Jeong Paik, Sung Jin Cho, In-Kyu Lee, David C. Whitcomb, Phil Greer, Brandon Blobner, Mark O. Goodarzi, Stephen J. Pandol, Jerome Rotter, Weiwei Fan, Sagar P. Bapat, Ye Zheng, Chris Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes, Eiji Yoshihara, Ronald M. Evans, Jae Myoung Suh
Summary: The phosphorylation of zinc finger protein and embryonic tumor cell locomotion coupling protein can regulate the migration ability of breast cancer cells.
Article
Multidisciplinary Sciences
Cristiane Lumi Hirata, Shinji Ito, Hiroshi Masutani