Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death

Glucagon-Like Peptide-1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in Humans

(2011) D. H. van Raalte et al.   DIABETES CARE

Nuclear Receptors and Inflammation Control: Molecular Mechanisms and Pathophysiological Relevance

(2010) Wendy Huang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Decreasing Txnip mRNA and Protein Levels in Pancreatic MIN6 Cells Reduces Reactive Oxygen Species and Restores Glucose Regulated Insulin Secretion

(2010) Sweta Rani et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic β-cells

(2010) Weijuan Shao et al.   CELLULAR SIGNALLING

Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men

(2010) Daniël H van Raalte et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells

(2010) Yunzhuo Ren et al.   FEBS LETTERS

Glucocorticoids: Extensive physiological actions modulated through multiple mechanisms of gene regulation

(2010) Nelo Eidy Zanchi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation

(2010) Z Chen et al.   LEUKEMIA

Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations

(2010) Shlomit Kfir-Erenfeld et al.   LEUKEMIA & LYMPHOMA

Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells

(2009) Xiaonan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lack of TXNIP Protects Against Mitochondria-Mediated Apoptosis but Not Against Fatty Acid-Induced ER Stress-Mediated  -Cell Death

(2009) J. Chen et al.   DIABETES

Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets

(2009) M. Shaked et al.   DIABETOLOGIA

Inhibition of Forkhead Box O1 Protects Pancreatic β-Cells against Dexamethasone-Induced Dysfunction

(2009) Xiongfei Zhang et al.   ENDOCRINOLOGY

Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?

(2009) D. H. van Raalte et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Glucose-stimulated Expression of Txnip Is Mediated by Carbohydrate Response Element-binding Protein, p300, and Histone H4 Acetylation in Pancreatic Beta Cells

(2009) Hyunjoo Cha-Molstad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of TXNIP protects β-cells against glucotoxicity: Figure 1

(2008) Anath Shalev   BIOCHEMICAL SOCIETY TRANSACTIONS

IGF-1 Protects Against Dexamethasone-Induced Cell Death in Insulin Secreting INS-1 Cells Independent of AKT/PKB Phosphorylation

(2008) Diana Avram et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

β-cell development: the role of intercellular signals

(2008) R. Scharfmann et al.   DIABETES OBESITY & METABOLISM

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes

(2008) Junqin Chen et al.   FASEB JOURNAL

Transgenic Expression of Antioxidant Protein Thioredoxin in Pancreatic β Cells Prevents Progression of Type 2 Diabetes Mellitus

(2007) Mayu Yamamoto et al.   ANTIOXIDANTS & REDOX SIGNALING