Carbonic Anhydrase 12 Protects Endplate Cartilage From Degeneration Regulated by IGF-1/PI3K/CREB Signaling Pathway

Cudratricusxanthone O Inhibits H2O2-Induced Cell Damage by Activating Nrf2/HO-1 Pathway in Human Chondrocytes

(2020) Eun-Nam Kim et al.   Antioxidants

Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells

(2019) Rui Zuo et al.   STEM CELLS

Lycorine Suppresses Endplate-Chondrocyte Degeneration and Prevents Intervertebral Disc Degeneration by Inhibiting NF-κB Signalling Pathway

(2018) Gangliang Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells

(2018) Gang Liu et al.   Molecular Cancer

The Influence of Direct Inoculation of Propionibacterium acnes on Modic Changes in the Spine

(2017) Zhi Shan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Effects of microRNA-206 and its target gene IGF-1 on sevoflurane-induced activation of hippocampal astrocytes in aged rats through the PI3K/AKT/CREB signaling pathway

(2017) Tie-Jun Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Non-specific low back pain

(2017) Chris Maher et al.   LANCET

MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis

(2017) Jun Lu et al.   MOLECULAR THERAPY

The effects of different doses of IGF-1 on cartilage and subchondral bone during the repair of full-thickness articular cartilage defects in rabbits

(2017) Z. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

The NLRP3/Caspase-1/Interleukin-1β Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration

(2016) Pan Tang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study

(2016) Shuai Chen et al.   LABORATORY INVESTIGATION

Intermittent cyclic mechanical tension promotes endplate cartilage degeneration via canonical Wnt signaling pathway and E-cadherin/β-catenin complex cross-talk

(2016) H.-g. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration

(2016) S. Ashraf et al.   OSTEOARTHRITIS AND CARTILAGE

Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas

(2016) Pia Viikilä et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Insulin-Like Growth Factor 1 Activates PI3k/Akt Signaling to Antagonize Lumbar Disc Degeneration

(2015) Zuoqing Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation

(2015) Huaming Xue et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

(2015) Yi Zhang et al.   Molecular Cancer

The role of the insulin-like growth factor-1 system in breast cancer

(2015) Panagiotis F Christopoulos et al.   Molecular Cancer

A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis

(2015) Haluk Yuzugullu et al.   Nature Communications

Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination

(2014) Marta Radwan et al.   ANNALS OF THE RHEUMATIC DISEASES

The global burden of occupationally related low back pain: estimates from the Global Burden of Disease 2010 study

(2014) T Driscoll et al.   ANNALS OF THE RHEUMATIC DISEASES

Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

(2014) M Mancini et al.   BRITISH JOURNAL OF CANCER

P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer

(2014) L M Dillon et al.   ONCOGENE

Molecular Interactions Between Human Cartilaginous Endplates and Nucleus Pulposus Cells

(2014) Cornelia Neidlinger-Wilke et al.   SPINE

Upregulation of Tumor Necrosis Factor α and ADAMTS-5, But Not ADAMTS-4, in Human Intervertebral Cartilage Endplate With Modic Changes

(2014) Shuai Chen et al.   SPINE

Tumor hypoxia and metabolism – Towards novel anticancer approaches

(2013) Johanna Chiche et al.   ANNALES D ENDOCRINOLOGIE

Ovarian Cancer G protein-Coupled Receptor 1 Is Involved in Acid-Induced Apoptosis of Endplate Chondrocytes in Intervertebral Discs

(2013) Feng-Lai Yuan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis

(2013) Jérome Doyen et al.   Frontiers in Oncology

Noninvasive Detection of Breast Cancer Lymph Node Metastasis Using Carbonic Anhydrases IX and XII Targeted Imaging Probes

(2011) N. K. Tafreshi et al.   CLINICAL CANCER RESEARCH

Expression profile of carbonic anhydrases in articular cartilage

(2011) Melissa Schultz et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Structure and Biology of the Intervertebral Disk in Health and Disease

(2011) Wilson C.W. Chan et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Intervertebral Disk Nutrition: A Review of Factors Influencing Concentrations of Nutrients and Metabolites

(2011) Thijs Grunhagen et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Human Disc Nucleus Properties and Vertebral Endplate Permeability

(2011) Azucena G. Rodriguez et al.   SPINE

Hyperchlorhidrosis Caused by Homozygous Mutation in CA12, Encoding Carbonic Anhydrase XII

(2010) Maya Feldshtein et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc cells

(2010) Jae-Sung Kim et al.   ARTHRITIS AND RHEUMATISM

The osseous endplates in lumbar vertebrae: Thickness, bone mineral density and their associations with age and disk degeneration

(2010) Yue Wang et al.   BONE

Chloride channel ClC-3 promotion of osteogenic differentiation through Runx2

(2010) Huan Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteogenic role of endosomal chloride channels in MC3T3-E1 cells

(2010) Huan Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adenocarcinoma (SGC7901) cells

(2009) Min Chen et al.   CELL BIOLOGY INTERNATIONAL

Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-κB signaling pathways

(2009) Xiu-Ying Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Estrogen Receptor Regulation of Carbonic Anhydrase XII through a Distal Enhancer in Breast Cancer

(2008) D. H. Barnett et al.   CANCER RESEARCH

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

(2008) Tue Secher Jensen et al.   EUROPEAN SPINE JOURNAL

Concepts in gene therapy for cartilage repair

(2008) Andre F. Steinert et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED