A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
出版年份 2015 全文链接
标题
A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
作者
关键词
-
出版物
Nature Communications
Volume 6, Issue 1, Pages -
出版商
Springer Nature
发表日期
2015-10-07
DOI
10.1038/ncomms9501
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
- (2015) Sarit Schwartz et al. CANCER CELL
- Abstract P6-10-07: Phase I study of BYL719, an alpha-specific PI3K inhibitor, in patients withPIK3CAmutant advanced solid tumors: preliminary efficacy and safety in patients withPIK3CAmutant ER-positive (ER+) metastatic breast cancer (MBC)
- (2014) D Juric et al. CANCER RESEARCH
- Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α
- (2014) Kira Gritsman et al. JOURNAL OF CLINICAL INVESTIGATION
- Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia
- (2014) Richard R. Furman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
- (2013) Esther Castellano et al. CANCER CELL
- RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
- (2013) Ralph Fritsch et al. CELL
- Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome
- (2013) Q. Wang et al. GENES & DEVELOPMENT
- Pten loss in the bone marrow leads to G-CSF–mediated HSC mobilization
- (2013) Melania Tesio et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
- (2012) Ian Bruce et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway
- (2012) Y. Li et al. BLOOD
- Targeting Nonclassical Oncogenes for Therapy in T-ALL
- (2012) Prem S. Subramaniam et al. CANCER CELL
- Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression
- (2012) Jeffrey A. Magee et al. Cell Stem Cell
- mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis
- (2012) Demetrios Kalaitzidis et al. Cell Stem Cell
- The p110 and p110 isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis
- (2012) T. Utermark et al. GENES & DEVELOPMENT
- Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia
- (2012) N I Noguera et al. LEUKEMIA
- Differential roles of Kras and Pten in murine leukemogenesis
- (2012) P Tang et al. LEUKEMIA
- Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
- (2012) Jay P. Patel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent
- (2012) Jing Ni et al. Cancer Discovery
- Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
- (2011) Inma M. Berenjeno et al. BIOCHEMICAL JOURNAL
- Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
- (2011) B. Mizukawa et al. BLOOD
- Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
- (2011) Abdelhafid Saci et al. MOLECULAR CELL
- CAL-101, a p110 selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
- (2010) B. J. Lannutti et al. BLOOD
- PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice
- (2009) C. Peng et al. BLOOD
- High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
- (2009) A. Gutierrez et al. BLOOD
- The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
- (2009) J. W. Vardiman et al. BLOOD
- Flow-Cytometric Phosphoprotein Analysis Reveals Agonist and Temporal Differences in Responses of Murine Hematopoietic Stem/Progenitor Cells
- (2008) Demetrios Kalaitzidis et al. PLoS One
- The p110 isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110
- (2008) J. Guillermet-Guibert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PTEN-deficient cancers depend on PIK3CB
- (2008) S. Wee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoinositide 3-Kinase p110 Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
- (2008) E. Ciraolo et al. Science Signaling
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