Article
Medicine, Research & Experimental
Deming Xu, Changbi Zhou, Juanyun Lin, Wenhui Cai, Wei Lin
Summary: This study found that sevoflurane promotes apoptosis of astrocytes, while miR-367-3p can reverse this effect and inhibit apoptosis. This suggests that miR-367-3p and BCL2L11 may be effective targets for the study of anesthesia.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Cell Biology
Xi Chen, Qing-Qing Tan, Xin-Rui Tan, Shi-Jun Li, Xing-Xing Zhang
Summary: In NAFLD models, circ_0057558 was found to increase while miR-206 decreased. miR-206 directly inhibited lipogenesis and TG secretion by binding to ROCK1 3'-UTR, and circ_0057558 bound to miR-206 to de-repress ROCK1/AMPK signaling. Knockdown of circ_0057558 or overexpression of miR-206 inhibited lipogenesis and TG secretion. ROCK1 knockdown reversed the effects of circ_0057558 overexpression.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Guoning Su, Yan Qu, Gang Li, Min Deng
Summary: The study found that SEV has a protective effect on cerebral ischemia/reperfusion injury (CIRI) by modulating the miR-30 c-5p-HIPK1 axis. Inhibition of HIPK1 can reverse the effect of reduced miR-30 c-5p on CIRI.
Review
Biochemistry & Molecular Biology
Duangnapa Kovanich, Teck Yew Low, Manuela Zaccolo
Summary: cAMP is a second messenger that plays a crucial role in regulating cellular functions. The compartmentalization of cAMP signaling is essential for its specificity, and the formation of dynamic signaling domains is responsible for precise spatiotemporal regulation. Proteomics can be used to identify the components of these domains and define the dynamic landscape of cellular cAMP signaling. Understanding compartmentalized cAMP signaling in physiological and pathological conditions can provide insights into disease mechanisms and guide the development of precision medicine interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Elia Mota, Segolene Bompierre, Dahdjim Betolngar, Liliana R. Castro, Pierre Vincent
Summary: This study reveals the functional contribution of PDE2A, PDE4, and PDE10A in regulating cAMP/PKA response to dopamine stimulation in the striatum. PDE10A is found to play a key role in reducing cAMP levels back to baseline and dephosphorylating PKA substrates. Inhibiting PDE10A dampens responsiveness to dopamine, while inhibiting PDE2A or PDE4 strengthens dopamine action.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: Entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB pathway, while also antagonizing the effects of TrkB receptor antagonist.
NEURAL REGENERATION RESEARCH
(2021)
Article
Cell Biology
Xiao-Li Yang, Yu-Shui Ma, Yu-Shan Liu, Xiao-Hui Jiang, Hua Ding, Yi Shi, Cheng-You Jia, Gai-Xia Lu, Dan-Dan Zhang, Hui-Min Wang, Pei-Yao Wang, Zhong-Wei Lv, Fei Yu, Ji-Bin Liu, Da Fu
Summary: miR-873 can suppress the self-renewal and proliferation of pancreatic cancer stem cells by blocking PLEK2-dependent PI3K/AKT pathway. This study contributes to understanding the role of miR-873 in pancreatic cancer stem cells and its underlying molecular mechanisms to aid in the development of effective pancreatic cancer therapeutics.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Qian Liu, Ruotong Tian, Panpan Yu, Minfeng Shu
Summary: The study identified that increasing cAMP levels can induce lineage-specific differentiation of glioma cells, with miR-221/222 suppression contributing to neuronal differentiation. The findings highlight the crucial role of the miR-221/222 cluster as an epigenetic brake during glioma differentiation.
Article
Biochemistry & Molecular Biology
Junliang Guo, Tian Tang, Jinhong Li, Yihong Yang, Yi Quan, Long Zhang, Wei Huang, Muchuan Zhou
Summary: The study explored the role of microRNA 142-5p (miR-142-5p) in cervical cancer by targeting the phosphoinositol-3 kinase adaptor protein 1 (PIK3AP1)/PI3K/AKT axis. Results showed that miR-142-5p targeted and inhibited PIK3AP1, leading to suppression of the PI3K/AKT signaling pathway and reduced proliferation, migration, and invasion of cervical cancer cells while enhancing apoptosis. This epigenetic regulation presents new targets for the treatment of cervical cancer.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Anesthesiology
Shao-yong Song, Ke Peng, Xiao-wen Meng, Xi-sheng Shan, Qing-cai Chen, Wei-ming Zhao, Biyu Shen, Hong Qiu, Hong Liu, Hua-yue Liu, Fu-hai Ji
Summary: In this study, the authors used single-nucleus RNA sequencing to investigate the effects of sevoflurane on different cell types in the hippocampus of mice. They found that sevoflurane exposure led to sex-specific alterations in cell populations and disrupted the functions of certain cell types in male mice, while showing different effects in female mice, particularly on oligodendrocytes. These findings provide important insights into the mechanisms of sevoflurane's actions during brain development.
Article
Cell Biology
Armando Jesus Perez-Diaz, Beatriz Vazquez-Marin, Jero Vicente-Soler, Francisco Prieto-Ruiz, Teresa Soto, Alejandro Franco, Jose Cansado, Marisa Madrid
Summary: The autophagy pathway in yeast is regulated differently in response to glucose limitation, indicating evolutionary variations in the signaling pathways that govern autophagy during glucose shortage or starvation.
Article
Medicine, Research & Experimental
Jili Zhao, Jinyu Ren, Shuang Liu, Yanan Gong, Ping Meng, Haitao Tan, Yonggang Chen
Summary: The study showed that neonatal exposure to Sev anesthesia induced cognitive impairment in adult rats, reducing the number of neurons and the concentration of BDNF in the hippocampus. Furthermore, Sev treatment decreased the expression of PKA, p-CREB, BDNF, and the p-CREB/CREB ratio, indicating the importance of PKA-CREB-BDNF signaling in cognitive decline caused by Sev exposure.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Roberta Paolillo, Stefania D'Apice, Gabriele Giacomo Schiattarella, Pietro Ameri, Domenica Borzacchiello, Daniele Catalucci, Cristina Chimenti, Lia Crotti, Sebastiano Sciarretta, Daniele Torella, Antonio Feliciello, Cinzia Perrino
Summary: The second messenger cAMP regulates multiple mitochondrial functions through the activation of cAMP/PKA signaling. AKAPs play important roles in regulating cardiac functions. Understanding the roles and regulation of mitochondria-targeted AKAPs can help modulate their functions for clinical purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Darja Lavogina, Artjom Stepanjuk, Maire Peters, Kulli Samuel, Sergo Kasvandik, Masuma Khatun, Riikka K. Arffman, Erki Enkvist, Kaido Viht, Sergei Kopanchuk, Freddy Lattekivi, Agne Velthut-Meikas, Asko Uri, Terhi T. Piltonen, Ago Rinken, Andres Salumets
Summary: The study identified elevated ROCK activity in response to combined progesterone and 8-Br-cAMP treatment during in vitro decidualization, leading to increased ROCK2 mRNA and protein levels as well as phosphorylation of its downstream target Cofilin-1. This research highlighted the importance of ROCK as a novel target in decidualization and the need for further investigation, especially in the context of subfertility and infertility related to decidualization.
HUMAN REPRODUCTION
(2021)
Article
Cell Biology
Kunming Zhang, Xiwen Sun, Weikai Sun, Meng Wang, Fushi Han
Summary: The study reveals that miR-506 enhances the sensitivity of LUAD cells to CDDP-based HT by inhibiting the ATAD2/PI3K/AKT signaling pathway, suggesting it as a potential therapeutic target for LUAD treatment.
CELLULAR SIGNALLING
(2022)