Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells

Nrf2: Molecular and epigenetic regulation during aging

(2018) A. Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Prevention and treatment of low back pain: evidence, challenges, and promising directions

(2018) Nadine E Foster et al.   LANCET

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

(2018) Bumsoo Ahn et al.   Redox Biology

The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders

(2017) Congcong Fang et al.   Oxidative Medicine and Cellular Longevity

Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

(2017) Gobinath Shanmugam et al.   Frontiers in Physiology

Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

(2017) Tiago L. Duarte et al.   Redox Biology

Autophagy: A double-edged sword in intervertebral disk degeneration

(2016) Shu-Jun Zhang et al.   CLINICA CHIMICA ACTA

Pathobiology of Modic changes

(2016) Stefan Dudli et al.   EUROPEAN SPINE JOURNAL

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

(2016) Benjamin L. Farah et al.   JOURNAL OF HEPATOLOGY

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia

(2016) Yuan Yao et al.   Stem Cell Reports

Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis

(2016) Qin Bian et al.   Scientific Reports

Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy

(2015) Jean-Paul Decuypere et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Autophagy and oxidative stress in cardiovascular diseases

(2015) Yu Mei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of the autophagy in myocardial ischemia/reperfusion injury

(2015) Sai Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability

(2015) Marialucia Gallorini et al.   BIOMATERIALS

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

(2015) Danielle R. Bruns et al.   Oxidative Medicine and Cellular Longevity

Autophagy in the Degenerating Human Intervertebral Disc

(2015) Helen E. Gruber et al.   SPINE

Oxidative stress and autophagy: Crucial modulators of kidney injury

(2015) Angara Sureshbabu et al.   Redox Biology

Autophagy protects end plate chondrocytes from intermittent cyclic mechanical tension induced calcification

(2014) Hong-guang Xu et al.   BONE

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

The Responses of Autophagy and Apoptosis to Oxidative Stress in Nucleus Pulposus Cells: Implications for Disc Degeneration

(2014) Jiang-Wei Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism

(2014) Libo Jiang et al.   CONNECTIVE TISSUE RESEARCH

Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells

(2014) Marina Klawitter et al.   EUROPEAN SPINE JOURNAL

Modic (endplate) changes in the lumbar spine: bone micro-architecture and remodelling

(2014) Egon Perilli et al.   EUROPEAN SPINE JOURNAL

Intervertebral disc regeneration: do nutrients lead the way?

(2014) Yong-Can Huang et al.   Nature Reviews Rheumatology

Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy

(2014) María Muriach et al.   Oxidative Medicine and Cellular Longevity

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

(2013) Xin Wen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

SOD1 and DJ-1 Converge at Nrf2 Pathway: A Clue for Antioxidant Therapeutic Potential in Neurodegeneration

(2013) Pamela Milani et al.   Oxidative Medicine and Cellular Longevity

The evidence and the possible significance of autophagy in degeneration model of human cervical end-plate cartilage

(2013) HONGGUANG XU et al.   Experimental and Therapeutic Medicine

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

(2011) Beatriz Caramés et al.   ANNALS OF THE RHEUMATIC DISEASES

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Characteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate

(2011) Lan-Tao Liu et al.   PLoS One

Endplate degeneration may be the origination of the vacuum phenomenon in intervertebral discs

(2010) Fang-Cai Li et al.   MEDICAL HYPOTHESES