Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

(2020) Ekaterina Friebel et al.   CELL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

(2020) Sampath K. Loganathan et al.   SCIENCE

Aging and Rejuvenation of Neural Stem Cells and Their Niches

(2020) Paloma Navarro Negredo et al.   Cell Stem Cell

ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models

(2020) Tou Yia Vue et al.   GLIA

Pharmacological disruption of the Notch transcription factor complex

(2020) Rajwinder Lehal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The substrate repertoire of γ-secretase/presenilin

(2020) Gökhan Güner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

(2020) Kai Miao et al.   Nature Communications

Sox2‐dependent maintenance of mouse oligodendroglioma involves the Sox2‐mediated downregulation of Cdkn2b, Ebf1, Zfp423, and Hey2

(2020) Cristiana Barone et al.   GLIA

The Oncogene Addiction Switch from NOTCH to PI3K Requires Simultaneous Targeting of NOTCH and PI3K Pathway Inhibition in Glioblastoma

(2019) Norihiko Saito et al.   Cancers

Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction

(2019) Sheila Alcantara Llaguno et al.   NATURE NEUROSCIENCE

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain

(2019) Risa Sueda et al.   GENES & DEVELOPMENT

Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells

(2019) Nishani Rajakulendran et al.   GENES & DEVELOPMENT

Stage-dependent regulation of oligodendrocyte development and enhancement of myelin repair by dominant negative Master-mind 1 protein

(2019) Xinqi Ge et al.   GLIA

Cell competition: the winners and losers of fitness selection

(2019) Sarah Bowling et al.   DEVELOPMENT

GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

(2019) Patricia Rusu et al.   Cell Stem Cell

Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus

(2019) Runrui Zhang et al.   Cell Reports

Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

(2019) Isabelle Maria Blomfield et al.   eLife

Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch

(2019) Youcef Ouadah et al.   CELL

Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest

(2019) Noelia Urbán et al.   NEURON

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

(2018) Jianghong Man et al.   Cell Stem Cell

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

(2018) Anna Engler et al.   Cell Reports

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

(2018) Ashwin Narayanan et al.   CELL DEATH AND DIFFERENTIATION

Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop

(2018) Jun Wang et al.   NATURE NEUROSCIENCE

Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone

(2017) Hiroki Kawai et al.   JOURNAL OF NEUROSCIENCE

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

(2017) Jing Shan Lim et al.   NATURE

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

(2017) Ryan D Chow et al.   NATURE NEUROSCIENCE

Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

(2017) Kosuke Aoki et al.   NEURO-ONCOLOGY

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Tenascin-C induces expression of the Notch ligand Jagged1 to promote glioma growth

(2017) Elena Parmigiani et al.   Translational Cancer Research

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma

(2016) Fanghui Lu et al.   CANCER CELL

RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

(2016) Qi Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in the molecular genetics of gliomas — implications for classification and therapy

(2016) Guido Reifenberger et al.   Nature Reviews Clinical Oncology

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

Neurogenesis in the Developing and Adult Brain—Similarities and Key Differences

(2016) Magdalena Götz et al.   Cold Spring Harbor Perspectives in Biology

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

(2016) Keisuke Katsushima et al.   Nature Communications

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

(2015) Claudio Giachino et al.   CANCER CELL

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a  -Secretase Inhibitor

(2015) K. Wang et al.   CLINICAL CANCER RESEARCH

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Mutational landscape and clonal architecture in grade II and III gliomas

(2015) Hiromichi Suzuki et al.   NATURE GENETICS

Integrated genomic characterization of IDH1-mutant glioma malignant progression

(2015) Hanwen Bai et al.   NATURE GENETICS

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells

(2015) Jinlong Yin et al.   PLOS BIOLOGY

Lateral inhibition of Notch signaling in neoplastic cells

(2015) Kah Jing Lim et al.   Oncotarget

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

Id2 Mediates Oligodendrocyte Precursor Cell Maturation Arrest and Is Tumorigenic in a PDGF-Rich Microenvironment

(2014) Matthew C. Havrda et al.   CANCER RESEARCH

Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner

(2014) Lin Wang et al.   Cell Stem Cell

Direct cell–cell contact with the vascular niche maintains quiescent neural stem cells

(2014) Cristina Ottone et al.   NATURE CELL BIOLOGY

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

(2014) Maria P. Alcolea et al.   NATURE CELL BIOLOGY

A new tumor suppressor role for the Notch pathway in bladder cancer

(2014) Theodoros Rampias et al.   NATURE MEDICINE

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

(2014) Jimena Andersen et al.   NEURON

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

(2014) Rui Pedro Galvao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-range enhancer activity determinesMycsensitivity to Notch inhibitors in T cell leukemia

(2014) Yumi Yashiro-Ohtani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

USP11 regulates PML stability to control Notch-induced malignancy in brain tumours

(2014) Hsin-Chieh Wu et al.   Nature Communications

Notching up neural stem cell homogeneity in homeostasis and disease

(2014) Claudio Giachino et al.   Frontiers in Neuroscience

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal

(2013) Yanyan Zheng et al.   CANCER CELL

Notch1-Induced Brain Tumor Models the Sonic Hedgehog Subgroup of Human Medulloblastoma

(2013) S. Natarajan et al.   CANCER RESEARCH

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

(2013) S. Licciulli et al.   CANCER RESEARCH

Common and Complex Notch1 Mutations in Chinese Oral Squamous Cell Carcinoma

(2013) Xiaomeng Song et al.   CLINICAL CANCER RESEARCH

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4

(2013) Eric J. Benner et al.   NATURE

Neural Stem Cells: Generating and Regenerating the Brain

(2013) Fred H. Gage et al.   NEURON

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population

(2013) Claudio Giachino et al.   STEM CELLS

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma

(2013) Esther Rheinbay et al.   Cell Reports

Molecular Pathways: Context-Dependent Approaches to Notch Targeting as Cancer Therapy

(2012) A. M. Egloff et al.   CLINICAL CANCER RESEARCH

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

(2012) Ian Krop et al.   JOURNAL OF CLINICAL ONCOLOGY

Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State

(2012) O. Basak et al.   JOURNAL OF NEUROSCIENCE

Passenger deletions generate therapeutic vulnerabilities in cancer

(2012) Florian L. Muller et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1

(2012) A Fassl et al.   ONCOGENE

Homeostatic neurogenesis in the adult hippocampus does not involve amplification of Ascl1high intermediate progenitors

(2012) Sebastian Lugert et al.   Nature Communications

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

(2011) D. Yao et al.   BLOOD

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis

(2011) M. Yoda et al.   BLOOD

The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

(2011) Shwetal Mehta et al.   CANCER CELL

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner

(2011) T. J. Pierfelice et al.   CANCER RESEARCH

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Notch in the Vertebrate Nervous System: An Old Dog with New Tricks

(2011) Tarran Pierfelice et al.   NEURON

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

(2011) N. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

(2011) C. Bettegowda et al.   SCIENCE

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

RBPJ -Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

(2010) O. Ehm et al.   JOURNAL OF NEUROSCIENCE

Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells

(2010) J. L. Ables et al.   JOURNAL OF NEUROSCIENCE

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

(2010) I. Imayoshi et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate

(2010) Koos E. Hovinga et al.   STEM CELLS

Tenascin-C Is a Novel RBPJ -Induced Target Gene for Notch Signaling in Gliomas

(2009) B. Sivasankaran et al.   CANCER RESEARCH

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells

(2009) Hyung-song Nam et al.   Cell Stem Cell

Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone

(2009) Celia Andreu-Agulló et al.   NATURE NEUROSCIENCE

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts

(2009) Xing Fan et al.   STEM CELLS

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

Notch-1 regulates transcription of the epidermal growth factor receptor through p53

(2008) Benjamin W. Purow et al.   CARCINOGENESIS

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions

(2008) Qin Shen et al.   Cell Stem Cell

Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms

(2008) Thorsten B. Feyerabend et al.   IMMUNITY

Adult T-cell progenitors retain myeloid potential

(2008) Haruka Wada et al.   NATURE

The earliest thymic progenitors for T cells possess myeloid lineage potential

(2008) J. Jeremiah Bell et al.   NATURE