Sox2‐dependent maintenance of mouse oligodendroglioma involves the Sox2‐mediated downregulation of Cdkn2b, Ebf1, Zfp423, and Hey2

A Sox2/miR-486-5p axis regulates survival of GBM cells by inhibiting tumor suppressor networks

(2020) Hernando Lopez-Bertoni et al.   CANCER RESEARCH

Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance

(2019) Jessica A. Bertolini et al.   Cell Stem Cell

Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets

(2019) Seth M. Rubin et al.   NATURE

RB constrains lineage fidelity and multiple stages of tumour progression and metastasis

(2019) David M. Walter et al.   NATURE

Regulation of glioma cell invasion by 3q26 gene products PIK3CA, SOX2 and OPA1

(2018) Thorsten Schaefer et al.   BRAIN PATHOLOGY

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

(2017) Harry Bulstrode et al.   GENES & DEVELOPMENT

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response

(2017) Quintino Giorgio D’Alessandris et al.   NEURO-ONCOLOGY

Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo

(2017) V Cesarini et al.   ONCOGENE

Sox2 is dispensable for primary melanoma and metastasis formation

(2017) S M Schaefer et al.   ONCOGENE

The dark side of SOX2: cancer - a comprehensive overview

(2017) Erin L. Wuebben et al.   Oncotarget

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

(2017) Dinesh K. Singh et al.   Cell Reports

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

(2017) Aram S. Modrek et al.   Cell Reports

Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

(2016) Elena Signaroldi et al.   Nature Communications

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome

(2016) G. Marziali et al.   Scientific Reports

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

(2015) Claudio Giachino et al.   CANCER CELL

Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact

(2015) P. Sathyan et al.   JOURNAL OF NEUROSCIENCE

Mutational landscape and clonal architecture in grade II and III gliomas

(2015) Hiromichi Suzuki et al.   NATURE GENETICS

Integrated genomic characterization of IDH1-mutant glioma malignant progression

(2015) Hanwen Bai et al.   NATURE GENETICS

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Sox2 acts as a transcriptional repressor in neural stem cells

(2014) Yu-Ru Liu et al.   BMC NEUROSCIENCE

Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

(2014) Rebecca Favaro et al.   CANCER RESEARCH

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2

(2013) Paul Guilhamon et al.   Nature Communications

Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade Glioma

(2012) Eleonora Gambini et al.   MOLECULAR THERAPY

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

(2011) Xuefeng Fang et al.   BMC GENOMICS

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

(2011) Katrin Arnold et al.   Cell Stem Cell

Genetic causes of glioma

(2011) Beatrice Melin   CURRENT OPINION IN ONCOLOGY

Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro

(2011) Sandra Gómez-López et al.   GLIA

Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition

(2011) M Ying et al.   ONCOGENE

Landscape of the SOX2 protein-protein interactome

(2011) Xuefeng Fang et al.   PROTEOMICS

Genetic advances in glioma: susceptibility genes and networks

(2010) Yanhong Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

A survey of glioblastoma genomic amplifications and deletions

(2009) Shailaja K. Rao et al.   JOURNAL OF NEURO-ONCOLOGY

Emerging Roles of the EBF Family of Transcription Factors in Tumor Suppression

(2009) D. Liao   MOLECULAR CANCER RESEARCH

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

(2009) Adam J Bass et al.   NATURE GENETICS

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

(2009) Rebecca Favaro et al.   NATURE NEUROSCIENCE

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme

(2008) R. Pallini et al.   CLINICAL CANCER RESEARCH

Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants

(2008) M. Cavallaro et al.   DEVELOPMENT

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS