标题
Therapeutic modulation of Notch signalling — are we there yet?
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 13, Issue 5, Pages 357-378
出版商
Springer Nature
发表日期
2014-04-30
DOI
10.1038/nrd4252
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of Tumor Angiogenesis and Tumor Growth by the DSL Domain of Human Delta-Like 1 Targeted to Vascular Endothelial Cells
- (2015) Xing-Cheng Zhao et al. NEOPLASIA
- Human Mesenchymal Stem Cells License Adult CD34+ Hemopoietic Progenitor Cells to Differentiate into Regulatory Dendritic Cells through Activation of the Notch Pathway
- (2014) Y.-P. Li et al. JOURNAL OF IMMUNOLOGY
- Abstract B48: A first-in-human Phase I study of the novel cancer stem cell (CSC) targeting antibody OMP-52M51 (anti-Notch1) administered intravenously to patients with certain advanced solid tumors.
- (2014) S. L. Davis et al. MOLECULAR CANCER THERAPEUTICS
- Somites Without a Clock
- (2014) A. S. Dias et al. SCIENCE
- Mutations in PDGFRB Cause Autosomal-Dominant Infantile Myofibromatosis
- (2013) John A. Martignetti et al. AMERICAN JOURNAL OF HUMAN GENETICS
- CCR2 Deficiency, Dysregulation of Notch Signaling, and Spontaneous Pulmonary Arterial Hypertension
- (2013) Yen-Rei A. Yu et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells
- (2013) Cindy R. Timme et al. APOPTOSIS
- Notch Inhibitor: a Promising Carcinoma Radiosensitizer
- (2013) Shu-Dong Yu et al. Asian Pacific Journal of Cancer Prevention
- Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy
- (2013) Yimin Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway
- (2013) Susanne Pettersson et al. BIOCHEMICAL JOURNAL
- NOTCH1 mutations influence survival in chronic lymphocytic leukemia patients
- (2013) Kerstin Willander et al. BMC CANCER
- Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL
- (2013) Marie Monet-Leprêtre et al. BRAIN
- The epigenetic landscape of oral squamous cell carcinoma
- (2013) P V Jithesh et al. BRITISH JOURNAL OF CANCER
- A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)
- (2013) S Sahebjam et al. BRITISH JOURNAL OF CANCER
- Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/β-catenin
- (2013) Jun Yao et al. CANCER BIOLOGY & THERAPY
- Selective Blockade of Transport via SERCA Inhibition: The Answer for Oncogenic Forms of Notch?
- (2013) Ma. Xenia G. Ilagan et al. CANCER CELL
- A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas
- (2013) Steffen Zender et al. CANCER CELL
- Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1
- (2013) Jia Lu et al. CANCER CELL
- Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer
- (2013) Giovanni Roti et al. CANCER CELL
- Activation of the NOTCH Pathway in Head and Neck Cancer
- (2013) W. Sun et al. CANCER RESEARCH
- The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability
- (2013) Bryan King et al. CELL
- In Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis
- (2013) Philmo Oh et al. Cell Stem Cell
- Mutations in PDGFRB and NOTCH3 are the first genetic causes identified for autosomal dominant infantile myofibromatosis
- (2013) JW Lee CLINICAL GENETICS
- Notch as a hub for signaling in angiogenesis
- (2013) Rui Benedito et al. EXPERIMENTAL CELL RESEARCH
- Dynamic binding of RBPJ is determined by Notch signaling status
- (2013) D. Castel et al. GENES & DEVELOPMENT
- Robust cellular reprogramming occurs spontaneously during liver regeneration
- (2013) K. Yanger et al. GENES & DEVELOPMENT
- Novel MIR143-NOTCH fusions in benign and malignant glomus tumors
- (2013) Juan-Miguel Mosquera et al. GENES CHROMOSOMES & CANCER
- A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors
- (2013) Ivan Diaz-Padilla et al. INVESTIGATIONAL NEW DRUGS
- A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575)
- (2013) Suzanne Richter et al. INVESTIGATIONAL NEW DRUGS
- Hair Cell Generation by Notch Inhibition in the Adult Mammalian Cristae
- (2013) Amber D. Slowik et al. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
- Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1
- (2013) Marie Blanke Andrawes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Blockade of individual Notch ligands and receptors controls graft-versus-host disease
- (2013) Ivy T. Tran et al. JOURNAL OF CLINICAL INVESTIGATION
- Whole exome sequencing of adenoid cystic carcinoma
- (2013) Philip J. Stephens et al. JOURNAL OF CLINICAL INVESTIGATION
- Notch pathway activation targets AML-initiating cell homeostasis and differentiation
- (2013) Camille Lobry et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Notch activation inhibits AML growth and survival: a potential therapeutic approach
- (2013) Sankaranarayanan Kannan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
- (2013) Inge Van de Walle et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The pathological significance of Notch1 in oral squamous cell carcinoma
- (2013) Ryoji Yoshida et al. LABORATORY INVESTIGATION
- Notch signaling in acute promyelocytic leukemia
- (2013) N R Grieselhuber et al. LEUKEMIA
- Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages
- (2013) Sanja Šale et al. NATURE CELL BIOLOGY
- Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
- (2013) Utpal B Pajvani et al. NATURE MEDICINE
- Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma
- (2013) Kunio Mizutari et al. NEURON
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Combined Inhibition of ErbB1/2 and Notch Receptors Effectively Targets Breast Ductal Carcinoma In Situ (DCIS) Stem/Progenitor Cell Activity Regardless of ErbB2 Status
- (2013) Gillian Farnie et al. PLoS One
- Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling
- (2013) X. Wang et al. SCIENCE
- Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers
- (2013) C. R. Pickering et al. Cancer Discovery
- Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
- (2013) Chandramouli R. Chillakuri et al. Cell Reports
- Notch Signaling and Bone Remodeling
- (2013) Jenna Regan et al. Current Osteoporosis Reports
- Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish an Antitumor Environment in the Skin
- (2012) Shadmehr Demehri et al. CANCER CELL
- Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting
- (2012) Matteo Di Piazza et al. CANCER CELL
- Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells
- (2012) Ming Qiu et al. CANCER LETTERS
- Notch signalling in smooth muscle cells during development and disease
- (2012) C. Fouillade et al. CARDIOVASCULAR RESEARCH
- A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis
- (2012) Duncan B. Sparrow et al. CELL
- Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin
- (2012) Laurence Meloty-Kapella et al. DEVELOPMENTAL CELL
- Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease
- (2012) José Luis de la Pompa et al. DEVELOPMENTAL CELL
- Fc-fusion proteins: new developments and future perspectives
- (2012) Daniel M. Czajkowsky et al. EMBO Molecular Medicine
- A phase II study of RO4929097 in metastatic colorectal cancer
- (2012) Jonathan R. Strosberg et al. EUROPEAN JOURNAL OF CANCER
- Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice
- (2012) Augusto Villanueva et al. GASTROENTEROLOGY
- Characterization of CSL (CBF-1, Su(H), Lag-1) Mutants Reveals Differences in Signaling Mediated by Notch1 and Notch2
- (2012) Zhenyu Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors
- (2012) Anthony W. Tolcher et al. JOURNAL OF CLINICAL ONCOLOGY
- PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
- (2012) C Shepherd et al. LEUKEMIA
- Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
- (2012) Ronny Falk et al. METHODS
- Dll4-Fc, an Inhibitor of Dll4-Notch Signaling, Suppresses Liver Metastasis of Small Cell Lung Cancer Cells through the Downregulation of the NF- B Activity
- (2012) T. Kuramoto et al. MOLECULAR CANCER THERAPEUTICS
- MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
- (2012) D. W. Jenkins et al. MOLECULAR CANCER THERAPEUTICS
- The biology and therapeutic targeting of the proprotein convertases
- (2012) Nabil G. Seidah et al. NATURE REVIEWS DRUG DISCOVERY
- The Notch signalling system: recent insights into the complexity of a conserved pathway
- (2012) K. G. Guruharsha et al. NATURE REVIEWS GENETICS
- Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells
- (2012) Rihua Jin et al. NEUROSCIENCE LETTERS
- Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
- (2012) S Jin et al. ONCOGENE
- Notch2 and Notch3 Function Together to Regulate Vascular Smooth Muscle Development
- (2012) Qingqing Wang et al. PLoS One
- Inhibition of Notch Signaling by a γ-Secretase Inhibitor Attenuates Hepatic Fibrosis in Rats
- (2012) Yixiong Chen et al. PLoS One
- Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region
- (2012) N. L. Stephenson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
- (2012) Gael Barthet et al. PROGRESS IN NEUROBIOLOGY
- A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands
- (2012) S. Yamamoto et al. SCIENCE
- Notch and disease: A growing field
- (2012) Angeliki Louvi et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
- (2012) Casper Groth et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Non-canonical Notch signaling: emerging role and mechanism
- (2012) Peter Andersen et al. TRENDS IN CELL BIOLOGY
- A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling
- (2012) Junzheng Zhang et al. G3-Genes Genomes Genetics
- Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL
- (2011) Meritxell Nus et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Orientation-regulated immobilization of Jagged1 on glass substrates for ex vivo proliferation of a bone marrow cell population containing hematopoietic stem cells
- (2011) Hiroyuki Toda et al. BIOMATERIALS
- Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma
- (2011) R. Kridel et al. BLOOD
- Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence
- (2011) K Pandya et al. BRITISH JOURNAL OF CANCER
- Vertebrate Segmentation: From Cyclic Gene Networks to Scoliosis
- (2011) Olivier Pourquié CELL
- Proteolytic Cleavage of Notch: “HIT and RUN”
- (2011) G. van Tetering et al. CURRENT MOLECULAR MEDICINE
- Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors
- (2011) Nadia A Rana et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila
- (2011) S. Munoz-Descalzo et al. DEVELOPMENT
- Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi
- (2011) R. Fernandez-Valdivia et al. DEVELOPMENT
- Notch signaling: simplicity in design, versatility in function
- (2011) E. R. Andersson et al. DEVELOPMENT
- Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development
- (2011) Tomoko Tateya et al. DEVELOPMENTAL BIOLOGY
- Translocation of the Cytoplasmic Domain of ADAM13 to the Nucleus Is Essential for Calpain8-a Expression and Cranial Neural Crest Cell Migration
- (2011) Hélène Cousin et al. DEVELOPMENTAL CELL
- Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice
- (2011) Zhenyi Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways
- (2011) Stacey Rentschler et al. JOURNAL OF CLINICAL INVESTIGATION
- Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation
- (2011) Giulia Fabbri et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Delta-Like Ligand 4–Notch Blockade and Tumor Radiation Response
- (2011) Stanley K. Liu et al. JNCI-Journal of the National Cancer Institute
- Notch Signaling Contributes to Lung Cancer Clonogenic Capacity In Vitro but May Be Circumvented in Tumorigenesis In Vivo
- (2011) J. Osanyingbemi-Obidi et al. MOLECULAR CANCER RESEARCH
- Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer
- (2011) Veronika Mamaeva et al. MOLECULAR THERAPY
- A somitic Wnt16/Notch pathway specifies haematopoietic stem cells
- (2011) Wilson K. Clements et al. NATURE
- A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
- (2011) Apostolos Klinakis et al. NATURE
- Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
- (2011) Xose S. Puente et al. NATURE
- Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
- (2011) Virginia Guarani et al. NATURE
- Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis
- (2011) Bertrand Isidor et al. NATURE GENETICS
- Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
- (2011) Michael A Simpson et al. NATURE GENETICS
- Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer
- (2011) Dan R Robinson et al. NATURE MEDICINE
- Treatment of pulmonary arterial hypertension with targeted therapies
- (2011) Dermot S. O'Callaghan et al. Nature Reviews Cardiology
- Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling
- (2011) E. Anders Kolb et al. PEDIATRIC BLOOD & CANCER
- Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms
- (2011) S. K.- J. Landor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
- (2011) N. J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
- (2011) N. Agrawal et al. SCIENCE
- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
- (2011) N. Stransky et al. SCIENCE
- Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment
- (2010) Hua Liu et al. CIRCULATION RESEARCH
- Wingless modulates the ligand independent traffic of Notch through Dishevelled
- (2010) Silvia Muñoz-Descalzo et al. FLY
- Molecular mechanisms of bile duct development
- (2010) Yiwei Zong et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors
- (2010) Kohei Yamamizu et al. JOURNAL OF CELL BIOLOGY
- Control of Notch-ligand endocytosis by ligand-receptor interaction
- (2010) E. M. Hansson et al. JOURNAL OF CELL SCIENCE
- Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation
- (2010) Luis Luna-Zurita et al. JOURNAL OF CLINICAL INVESTIGATION
- Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
- (2010) Anne Joutel et al. JOURNAL OF CLINICAL INVESTIGATION
- Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves
- (2010) Rajan Jain et al. JOURNAL OF CLINICAL INVESTIGATION
- Chronic DLL4 blockade induces vascular neoplasms
- (2010) Minhong Yan et al. NATURE
- Therapeutic antibody targeting of individual Notch receptors
- (2010) Yan Wu et al. NATURE
- Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
- (2010) Lars Jakobsson et al. NATURE CELL BIOLOGY
- Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin
- (2010) Alexis Dumortier et al. PLoS One
- γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane
- (2010) Erika B. Sorensen et al. TRAFFIC
- The Multiple Facets of Ubiquitination in the Regulation of Notch Signaling Pathway
- (2010) Stéphanie Le Bras et al. TRAFFIC
- Induction of notch signaling by immobilization of jagged-1 on self-assembled monolayers
- (2009) Raquel M. Gonçalves et al. BIOMATERIALS
- Preclinical Profile of a Potent -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties
- (2009) L. Luistro et al. CANCER RESEARCH
- -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity
- (2009) R. D. Meng et al. CANCER RESEARCH
- The role of Notch in patterning the human vertebral column
- (2009) Sally L Dunwoodie CURRENT OPINION IN GENETICS & DEVELOPMENT
- Transcriptional Mechanisms by the Coregulator MAML1
- (2009) M. Just Ribeiro et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase
- (2009) Thomas Tousseyn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting onO-Glucosylated Notch Epidermal Growth Factor Repeats
- (2009) Maya K. Sethi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Notch1 represses osteogenic pathways in aortic valve cells
- (2009) Vishal Nigam et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Direct inhibition of the NOTCH transcription factor complex
- (2009) Raymond E. Moellering et al. NATURE
- Notch3 signaling promotes the development of pulmonary arterial hypertension
- (2009) Xiaodong Li et al. NATURE MEDICINE
- Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2
- (2009) Wendy R. Gordon et al. PLoS One
- Mutations in the MESP2 Gene Cause Spondylothoracic Dysostosis/Jarcho-Levin Syndrome
- (2008) Alberto S. Cornier et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Downregulation of Notch signaling by γ-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines
- (2008) Shuangyou Liu et al. ANNALS OF HEMATOLOGY
- Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease
- (2008) Adam S. Fleisher et al. ARCHIVES OF NEUROLOGY
- Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
- (2008) Melih Acar et al. CELL
- Transcriptome Analysis of the Normal Human Mammary Cell Commitment and Differentiation Process
- (2008) Afshin Raouf et al. Cell Stem Cell
- Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment
- (2008) Toula Bouras et al. Cell Stem Cell
- Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
- (2008) Ivan Maillard et al. Cell Stem Cell
- Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells
- (2008) Shaobo Jin et al. CIRCULATION RESEARCH
- Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis
- (2008) D. B. Sparrow et al. HUMAN MOLECULAR GENETICS
- Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
- (2008) Kang Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model
- (2008) Benjamin L. Beckstead et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Endosomal entry regulates Notch receptor activation inDrosophila melanogaster
- (2008) Thomas Vaccari et al. JOURNAL OF CELL BIOLOGY
- Stabilized -Catenin Functions through TCF/LEF Proteins and the Notch/RBP-J Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells
- (2008) T. Shimizu et al. MOLECULAR AND CELLULAR BIOLOGY
- A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
- (2008) Jemima Cordle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways
- (2008) A S McElhinny et al. ONCOGENE
- Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
- (2008) X. Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity
- (2008) Shadmehr Demehri et al. PLOS BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started