The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for RNA polymerase III transcription repression by Maf1

(2020) Matthias K. Vorländer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity

(2020) Guillermo Martínez Corrales et al.   Cell Reports

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

(2020) Esther van Dam et al.   Cell Metabolism

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1

(2020) María Rodríguez-López et al.   Cell Reports

Activation and targeting of ATG8 protein lipidation

(2020) Sascha Martens et al.   Cell Discovery

Nuclear Functions of TOR: Impact on Transcription and the Epigenome

(2020) R. Nicholas Laribee et al.   Genes

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

(2019) Zhou Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

History of The Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?

(2019) Vladimir Kirkin   JOURNAL OF MOLECULAR BIOLOGY

mTOR and Aging: An Old Fashioned Dress

(2019) Giovanni Stallone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The multi-faceted regulation of nuclear tRNA gene transcription

(2019) Guillaume Hummel et al.   IUBMB LIFE

A hidden human proteome encoded by ‘non-coding’ genes

(2019) Shaohua Lu et al.   NUCLEIC ACIDS RESEARCH

Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate

(2019) Julie Candiracci et al.   Science Advances

The Emerging Roles of mTORC1 in Macromanaging Autophagy

(2019) Akpedje S. Dossou et al.   Cancers

The cell stress response: extreme times call for post‐transcriptional measures

(2019) Mariavittoria Pizzinga et al.   Wiley Interdisciplinary Reviews-RNA

Agephagy – Adapting Autophagy for Health During Aging

(2019) Eleanor R. Stead et al.   Frontiers in Cell and Developmental Biology

Maf1‐dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan

(2019) Mihir Shetty et al.   AGING CELL

Factors that affect the translation of dietary restriction into a longer life

(2019) Jakob Frieling et al.   IUBMB LIFE

Growth Factor-Dependent and -Independent Activation of mTORC2

(2019) Jonas R. Knudsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Who does TORC2 talk to?

(2018) Jianling Xie et al.   BIOCHEMICAL JOURNAL

Regulation of tRNA synthesis by the general transcription factors of RNA polymerase III - TFIIIB and TFIIIC, and by the MAF1 protein

(2018) Damian Graczyk et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

(2018) Tamara Suhm et al.   Cell Metabolism

tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway

(2018) Yoko Otsubo et al.   EMBO REPORTS

Autophagy during ageing - from Dr Jekyll to Mr Hyde

(2018) Thomas Wilhelm et al.   FEBS Journal

TOR complex 2 in fission yeast is required for chromatin-mediated gene silencing and assembly of heterochromatic domains at subtelomeres

(2018) Adiel Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Nucleolar Function in Lifespan Regulation

(2018) Varnesh Tiku et al.   TRENDS IN CELL BIOLOGY

Phosphorylation and Signal Transduction Pathways in Translational Control

(2018) Christopher G. Proud   Cold Spring Harbor Perspectives in Biology

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life

(2018) Naomi R. Genuth et al.   MOLECULAR CELL

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Translation deregulation in human disease

(2018) Soroush Tahmasebi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein synthesis and quality control in aging

(2018) Aleksandra S. Anisimova et al.   Aging-US

SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction

(2018) Masaki Kobayashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

RNA polymerase III limits longevity downstream of TORC1

(2017) Danny Filer et al.   NATURE

mTOR-sensitive translation: Cleared fog reveals more trees

(2017) Laia Masvidal et al.   RNA Biology

Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes

(2017) Charalampos Rallis et al.   Scientific Reports

The control of translational accuracy is a determinant of healthy ageing in yeast

(2017) Tobias von der Haar et al.   Open Biology

Gerosuppression by pan-mTOR inhibitors

(2016) Olga V. Leontieva et al.   Aging-US

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

iLIR database: A web resource for LIR motif-containing proteins in eukaryotes

(2016) Anne-Claire Jacomin et al.   Autophagy

HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis

(2016) Xian-Wu Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Ribosomal Perspective on Proteostasis and Aging

(2016) Kristan K. Steffen et al.   Cell Metabolism

Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis

(2016) Yujia Yuan et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Systematic discovery of cap-independent translation sequences in human and viral genomes

(2016) Shira Weingarten-Gabbay et al.   SCIENCE

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion

(2016) Ying Cai et al.   Oncotarget

Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans

(2016) Frederick G. Mann et al.   PLoS Genetics

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

(2016) Olga V. Leontieva et al.   Aging-US

Inhibition of TORC1 signaling and increased lifespan: gained in translation?

(2016) Charalampos Rallis et al.   Aging-US

GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

(2016) Julien Averous et al.   Scientific Reports

Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9

(2015) Ying Cai et al.   Aging-US

The race to decipher the top secrets of TOP mRNAs

(2015) Oded Meyuhas et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

(2015) Marcel Tiebe et al.   DEVELOPMENTAL CELL

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

SREBP and MDT-15 protectC. elegansfrom glucose-induced accelerated aging by preventing accumulation of saturated fat

(2015) Dongyeop Lee et al.   GENES & DEVELOPMENT

The S6K protein family in health and disease

(2015) Mariana R. Tavares et al.   LIFE SCIENCES

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1

(2015) Dana Laor et al.   mBio

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification

(2015) Aneeshkumar G. Arimbasseri et al.   PLoS Genetics

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

(2015) Deliang Guo et al.   CURRENT PHARMACEUTICAL DESIGN

Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast

(2015) Yan Ma et al.   PLoS One

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

TORC2--a new player in genome stability

(2014) R. Weisman et al.   EMBO Molecular Medicine

Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD+ Levels

(2014) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

TOR Signaling Couples Oxygen Sensing to Lifespan in C. elegans

(2014) Michael Schieber et al.   Cell Reports

MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and III

(2014) K. J. Campbell et al.   Cold Spring Harbor Perspectives in Medicine

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

(2013) Charalampos Rallis et al.   AGING CELL

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Growth or longevity: the TOR’s decision on lifespan regulation

(2013) Yuehua Wei et al.   BIOGERONTOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy

(2013) Hitoshi Nakatogawa   Essays in Biochemistry

Metabolic Control by Target of Rapamycin and Autophagy during Ageing - A Mini-Review

(2013) Maria Markaki et al.   GERONTOLOGY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3

(2013) Julia Brenmoehl et al.   MITOCHONDRION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases

(2012) Jaehoon Lee et al.   MOLECULAR CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

The Fission Yeast GATA Factor, Gaf1, Modulates Sexual Development via Direct Down-Regulation of ste11+ Expression in Response to Nitrogen Starvation

(2012) Lila Kim et al.   PLoS One

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct perturbation of the translatome by the antidiabetic drug metformin

(2012) O. Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe

(2011) N. Ikai et al.   Open Biology

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Sterol Regulatory Element-binding Protein (SREBP)-1-mediated Lipogenesis Is Involved in Cell Senescence

(2010) You-Mie Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

(2010) Kirk A. Staschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress

(2009) S. Hartmuth et al.   JOURNAL OF CELL SCIENCE

TOR Complex 2 Controls Gene Silencing, Telomere Length Maintenance, and Survival under DNA-Damaging Conditions

(2009) M. Schonbrun et al.   MOLECULAR AND CELLULAR BIOLOGY

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation

(2008) Yuri V Svitkin et al.   EMBO JOURNAL

Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation

(2008) Luis López-Maury et al.   NATURE REVIEWS GENETICS