Factors that affect the translation of dietary restriction into a longer life

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

(2019) Priya Rangan et al.   Cell Reports

Drosophila melanogaster in nutrition research—the importance of standardizing experimental diets

(2019) Kai Lüersen et al.   Genes and Nutrition

Diet restriction-induced healthy aging is mediated through the immune signaling component ZIP-2 in Caenorhabditis elegans

(2019) Jeong-Hoon Hahm et al.   AGING CELL

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

(2019) Gil Sharon et al.   CELL

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

The Microbiome and Aging

(2019) Bianca Bana et al.   Annual Review of Genetics

Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

(2019) Latika Matai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity

(2019) Jorge Iván Castillo-Quan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

(2018) Francesca Cignarella et al.   Cell Metabolism

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

(2018) Eleni Beli et al.   DIABETES

Metabolic vulnerability of cisplatin‐resistant cancers

(2018) Florine Obrist et al.   EMBO JOURNAL

Nutritional regimens with periodically recurring phases of dietary restriction extend lifespan in Drosophila

(2018) Renja Romey-Glüsing et al.   FASEB JOURNAL

Dietary Tryptophan Restriction Dose-Dependently Modulates Energy Balance, Gut Hormones, and Microbiota in Obesity-Prone Rats

(2018) Rizaldy C. Zapata et al.   Obesity

Starvation, Stress Resistance, and Cancer

(2018) Roberta Buono et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves

(2018) Yaru Liang et al.   Scientific Reports

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

You are what you eat: diet, health and the gut microbiota

(2018) Niv Zmora et al.   Nature Reviews Gastroenterology & Hepatology

Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy

(2018) Jakob von Frieling et al.   Frontiers in Microbiology

Reconciling nutritional geometry with classical dietary restriction: Effects of nutrient intake, not calories, on survival and reproduction

(2018) Joshua P. Moatt et al.   AGING CELL

Implications of amino acid sensing and dietary protein to the aging process

(2018) Oleh Lushchak et al.   EXPERIMENTAL GERONTOLOGY

Key proteins and pathways that regulate lifespan

(2017) Haihui Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Aging and the Human Gut Microbiota

(2017) Vincent J Maffei et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The 4E-BP growth pathway regulates the effect of ambient temperature onDrosophilametabolism and lifespan

(2017) Gil B. Carvalho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila

(2017) Jung-Eun Lee et al.   Cell Reports

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Amino acid modulation of lifespan and reproduction in Drosophila

(2017) Katja M Hoedjes et al.   Current Opinion in Insect Science

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

(2017) Floris Fransen et al.   Frontiers in Immunology

From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

(2016) R. Scott McIsaac et al.   Annals of the New York Academy of Sciences

Dietary Protein, Metabolism, and Aging

(2016) George A. Soultoukis et al.   Annual Review of Biochemistry

The Drosophila transcriptional network is structured by microbiota

(2016) Adam J. Dobson et al.   BMC GENOMICS

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

Resveratrol and Lifespan in Model Organisms

(2016) Kathrin Pallauf et al.   CURRENT MEDICINAL CHEMISTRY

The conserved role of protein restriction in aging and disease

(2016) Hamed Mirzaei et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

(2016) J.R. Speakman et al.   EXPERIMENTAL GERONTOLOGY

Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila

(2016) Julia Hoffmann et al.   Aging-US

Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster

(2016) Rachel Whitaker et al.   Aging-US

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

(2015) Clare Edwards et al.   BMC GENETICS

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

(2015) Cathy Slack et al.   CELL

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

(2015) Sebastian Brandhorst et al.   Cell Metabolism

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

(2015) S. Gill et al.   SCIENCE

TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium

(2015) Y Zhou et al.   Cell Death & Disease

Effects of nutritional components on aging

(2014) Dongyeop Lee et al.   AGING CELL

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

(2014) Felix Sommer et al.   PLoS One

Intermittent Fasting Promotes Bacterial Clearance and Intestinal IgA Production inSalmonella typhimurium-Infected Mice

(2014) M. Godínez-Victoria et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Diet Studies Challenge Thinking on Proteins Versus Carbs

(2014) J. Couzin-Frankel   SCIENCE

Protein and amino acid restriction, aging and disease: from yeast to humans

(2014) Hamed Mirzaei et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

(2014) Nazif Alic et al.   PLoS Genetics

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Comparative and meta-analytic insights into life extension via dietary restriction

(2012) Shinichi Nakagawa et al.   AGING CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner

(2012) Kushal Kr. Banerjee et al.   Cell Reports

Lactobacillus plantarum Promotes Drosophila Systemic Growth by Modulating Hormonal Signals through TOR-Dependent Nutrient Sensing

(2011) Gilles Storelli et al.   Cell Metabolism

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About Longevity

(2010) Z. D. Sharp et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Converging Pathways in Lifespan Regulation

(2009) Sri Devi Narasimhan et al.   CURRENT BIOLOGY

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Signaling networks in aging

(2008) Eric L. Greer et al.   JOURNAL OF CELL SCIENCE

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA