Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

(2020) Sheila K. Pirooznia et al.   Molecular Neurodegeneration

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Progress of pharmacological approaches in Parkinson's disease

(2019) Kirsten E. Zeuner et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

(2019) Fieke Wauters et al.   Autophagy

Will genotype drive treatment options?

(2019) Norbert Brüggemann et al.   MOVEMENT DISORDERS

Mitochondrial DNA Deletions Discriminate Affected from Unaffected LRRK2 Mutation Carriers

(2019) Nassima Ouzren et al.   ANNALS OF NEUROLOGY

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Vitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells

(2019) Cristina Cerqua et al.   Scientific Reports

Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease

(2019) Md. Ezazul Haque et al.   MOVEMENT DISORDERS

PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

(2019) Shireen A. Sarraf et al.   Cell Reports

Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues

(2019) Chun Chen et al.   NEUROBIOLOGY OF DISEASE

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

(2018) Ye Xi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

(2018) Jaime N. Guzman et al.   JOURNAL OF CLINICAL INVESTIGATION

Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin , PINK1 , DJ1: MDSGene Systematic Review

(2018) Meike Kasten et al.   MOVEMENT DISORDERS

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

ER–mitochondria signaling in Parkinson’s disease

(2018) Patricia Gómez-Suaga et al.   Cell Death & Disease

Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?

(2018) Gábor Zsurka et al.   Genes

Rare genetic variation in mitochondrial pathways influences the risk for parkinson's disease

(2018) Johannes J. Gaare et al.   MOVEMENT DISORDERS

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models

(2018) Kyu-Sun Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the complex role of mitochondria in Parkinson’s disease

(2018) Anne Grünewald et al.   PROGRESS IN NEUROBIOLOGY

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

(2018) Jonathan P Bernardini et al.   EMBO JOURNAL

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review

(2018) Joanne Trinh et al.   MOVEMENT DISORDERS

POLG-related disorders and their neurological manifestations

(2018) Shamima Rahman et al.   Nature Reviews Neurology

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

(2018) Yoshikuni Tabata et al.   Stem Cell Reports

CHCHD10 is involved in the development of Parkinson's disease caused by CHCHD2 loss-of-function mutation p.T61I

(2018) Chengyuan Mao et al.   NEUROBIOLOGY OF AGING

The role of monogenic genes in idiopathic Parkinson’s disease

(2018) Xylena Reed et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease

(2017) Maria Pia Giannoccaro et al.   MOVEMENT DISORDERS

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

(2017) Francois Mouton-Liger et al.   Frontiers in Molecular Neuroscience

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

(2017) Jonathan Arias-Fuenzalida et al.   Stem Cell Reports

Are rodent models of Parkinson’s disease behaving as they should?

(2017) Siv Vingill et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons

(2016) Anne Grünewald et al.   ANNALS OF NEUROLOGY

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

(2016) Dorien A. Roosen et al.   Molecular Neurodegeneration

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

Nomenclature of genetic movement disorders: Recommendations of the international Parkinson and movement disorder society task force

(2016) Connie Marras et al.   MOVEMENT DISORDERS

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Clinical, Genetic, and Radiological Features of Extrapyramidal Movement Disorders in Mitochondrial Disease

(2016) Mika H. Martikainen et al.   JAMA Neurology

CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study

(2015) Manabu Funayama et al.   LANCET NEUROLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Parkinson's disease–associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

(2015) Wenzhang Wang et al.   NATURE MEDICINE

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration

(2015) Daniel A. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function

(2015) Fu-Lei Tang et al.   Cell Reports

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

Parkin and mitochondrial quality control: toward assembling the puzzle

(2014) Konstanze F. Winklhofer   TRENDS IN CELL BIOLOGY

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

(2014) et al.   JAMA Neurology

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

Mitochondrial respiration without ubiquinone biosynthesis

(2013) Ying Wang et al.   HUMAN MOLECULAR GENETICS

The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering

(2013) D. Ottolini et al.   HUMAN MOLECULAR GENETICS

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art

(2013) Lorenzo Kiferle et al.   NEUROSCIENCE LETTERS

Next-Generation Phenotyping Using theParkinExample

(2013) Anne Grünewald et al.   JAMA Neurology

Meta-analysis of early nonmotor features and risk factors for Parkinson disease

(2012) Alastair J. Noyce et al.   ANNALS OF NEUROLOGY

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy

(2012) Aleksandar Rakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly

(2012) Jun Young Heo et al.   PLoS One

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

(2012) Vincent Soubannier et al.   PLoS One

Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

(2012) M. Vos et al.   SCIENCE

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Monoamine Oxidase B Inhibitors for the Treatment of Parkinsonʼs Disease

(2011) Anthony H.V. Schapira   CNS DRUGS

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis

(2011) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFAM forces mtDNA to make a U-turn

(2011) B Martin Hallberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

(2011) E. Ilijic et al.   NEUROBIOLOGY OF DISEASE

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

POLG1 polyglutamine tract variants associated with Parkinson's disease

(2010) Johanna Eerola et al.   NEUROSCIENCE LETTERS

Variations of the CAG trinucleotide repeat in DNA polymerase gamma (POLG1) is associated with Parkinson's disease in Sweden

(2010) Anna Anvret et al.   NEUROSCIENCE LETTERS

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release

(2009) A. K. Berger et al.   HUMAN MOLECULAR GENETICS

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

(2009) Oliver Rothfuss et al.   HUMAN MOLECULAR GENETICS

A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson's Disease

(2009) C. Warren Olanow et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA polymerase gamma and mitochondrial disease: Understanding the consequence of POLG mutations

(2008) Sherine S.L. Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegenerative parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation

(2008) Wim Vandenberghe et al.   MOVEMENT DISORDERS