Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells

Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration

(2020) Nazir M. Khan et al.   Genes

Transcriptional profiling of the murine intervertebral disc and age-associated changes in the nucleus pulposus

(2019) Matthew A. Veras et al.   CONNECTIVE TISSUE RESEARCH

Dickkopf Homolog 3 (DKK3) Acts as a Potential Tumor Suppressor in Gallbladder Cancer

(2019) Kirti Gondkar et al.   Frontiers in Oncology

Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell‐transcriptomics

(2019) Martha E. Diaz‐Hernandez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming

(2018) Xin Liu et al.   DEVELOPMENT

Quality Assessment of Surgical Disc Samples Discriminates Human Annulus Fibrosus and Nucleus Pulposus on Tissue and Molecular Level

(2018) Ann-Kathrin Schubert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues

(2018) Scott M. Riester et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Comprehensive evaluation of differential lncRNA and gene expression in patients with intervertebral disc degeneration

(2018) Zhigang Qu et al.   Molecular Medicine Reports

Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB–Wnt5a negative-feedback loop

(2018) Z. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging

(2018) Di Chen et al.   Annals of the New York Academy of Sciences

Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice

(2018) Lorenzo M. Fernandes et al.   Scientific Reports

Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc

(2018) Ricardo Rodrigues-Pinto et al.   Scientific Reports

Potential biomarkers of the mature intervertebral disc identified at the single cell level

(2018) Kangning Li et al.   JOURNAL OF ANATOMY

Transcriptional profiling distinguishes inner and outer annulus fibrosus from nucleus pulposus in the bovine intervertebral disc

(2017) Guus G. H. van den Akker et al.   EUROPEAN SPINE JOURNAL

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells

(2017) Chengjie Lian et al.   Molecular Medicine Reports

SC3: consensus clustering of single-cell RNA-seq data

(2017) Vladimir Yu Kiselev et al.   NATURE METHODS

Intervertebral Disk Degeneration and Repair

(2017) James Dowdell et al.   NEUROSURGERY

The Role of Hypoxia in Angiogenesis and Extracellular Matrix Regulation of Intervertebral Disc Cells During Inflammatory Reactions

(2017) Woo-Keun Kwon et al.   NEUROSURGERY

Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions

(2017) S Murai et al.   Oncogenesis

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration

(2017) Stephen M. Richardson et al.   Scientific Reports

Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus

(2017) Sun H. Peck et al.   Scientific Reports

Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes

(2017) Abdul Haseeb et al.   Scientific Reports

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Identification of Long Noncoding RNAs in Human Intervertebral Disc Degeneration by RNA Sequencing

(2016) Bo Zhao et al.   Biomed Research International

Novel endogenous angiogenesis inhibitors and their therapeutic potential

(2015) Nithya Rao et al.   ACTA PHARMACOLOGICA SINICA

CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks

(2015) Yu Tang et al.   BIOSYSTEMS

Gene-expression and in vitro function of mesenchymal stromal cells are affected in juvenile myelomonocytic leukemia

(2015) F. G. J. Calkoen et al.   HAEMATOLOGICA

Epigenetic Downregulation of SFRP4 Contributes to Epidermal Hyperplasia in Psoriasis

(2015) Jing Bai et al.   JOURNAL OF IMMUNOLOGY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Understanding Nucleus Pulposus Cell Phenotype: A Prerequisite for Stem Cell Based Therapies to Treat Intervertebral Disc Degeneration

(2015) Hyowon Choi et al.   Current Stem Cell Research & Therapy

Gene-expression and in vitro function of mesenchymal stromal cells are affected in juvenile myelomonocytic leukemia

(2015) F. G. J. Calkoen et al.   HAEMATOLOGICA

Proteomic Signature of the Murine Intervertebral Disc

(2015) Matthew R. McCann et al.   PLoS One

Angiopoietin-Like 7 Is an Anti-Angiogenic Protein Required to Prevent Vascularization of the Cornea

(2015) Tetsuya Toyono et al.   PLoS One

Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies

(2014) SZ. Wang et al.   CELL PROLIFERATION

Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability

(2014) Susana F. Rocha et al.   CIRCULATION RESEARCH

An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration

(2014) Ricardo Rodrigues-Pinto et al.   EUROPEAN SPINE JOURNAL

Enhanced Gastrointestinal Expression of Cytosolic Malic Enzyme (ME1) Induces Intestinal and Liver Lipogenic Gene Expression and Intestinal Cell Proliferation in Mice

(2014) Ahmed Al-Dwairi et al.   PLoS One

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

(2014) Rekin's Janky et al.   PLoS Computational Biology

Gene expression profile analysis of human intervertebral disc degeneration

(2013) Kai Chen et al.   GENETICS AND MOLECULAR BIOLOGY

In search of nucleus pulposus-specific molecular markers

(2013) F. Lv et al.   RHEUMATOLOGY

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

(2013) Lucas A Smolders et al.   ARTHRITIS RESEARCH & THERAPY

Microarray analysis of genes and gene functions in disc degeneration

(2013) YANCHUN TANG et al.   Experimental and Therapeutic Medicine

Identification of novel nucleus pulposus markers

(2013) R. Rodrigues-Pinto et al.   Bone & Joint Research

Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue

(2012) Meina Wang et al.   ARTHRITIS AND RHEUMATISM

Diversity of intervertebral disc cells: phenotype and function

(2012) Girish Pattappa et al.   JOURNAL OF ANATOMY

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

(2012) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

A travel guide to Cytoscape plugins

(2012) Rintaro Saito et al.   NATURE METHODS

Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of the Intervertebral Disc

(2011) Jessica Czamanski Salvatierra et al.   Cellular and Molecular Bioengineering

Biomechanics of Intervertebral Disk Degeneration

(2011) Nozomu Inoue et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling

(2011) Naoki Kondo et al.   SPINE

Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers

(2010) Audrey Gilson et al.   ARTHRITIS RESEARCH & THERAPY

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

(2010) Ben M Minogue et al.   ARTHRITIS RESEARCH & THERAPY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice

(2009) Wei Xiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

(2009) Haluk Yuzugullu et al.   Molecular Cancer

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Differential Phenotype of Intervertebral Disc Cells

(2009) Daisuke Sakai et al.   SPINE

The Rat Genome Database Curators: Who, What, Where, Why

(2009) Mary Shimoyama et al.   PLoS Computational Biology

Matrix Remodeling During Intervertebral Disc Growth and Degeneration Detected by Multichromatic FAST Staining

(2008) Victor Y.L. Leung et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Rat Genome Database 2009: variation, ontologies and pathways

(2008) M. R. Dwinell et al.   NUCLEIC ACIDS RESEARCH

Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment

(2008) P. Prithvi Raj   Pain Practice