Intervertebral Disk Degeneration and Repair

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

Molecular mechanisms of biological aging in intervertebral discs

(2016) Nam V. Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo

(2016) Alon Lai et al.   Spine Journal

Advancing the cellular and molecular therapy for intervertebral disc disease

(2015) Daisuke Sakai et al.   ADVANCED DRUG DELIVERY REVIEWS

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

(2015) Daisuke Sakai et al.   Nature Reviews Rheumatology

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug

(2015) Morakot Likhitpanichkul et al.   Spine Journal

The biological basis of degenerative disc disease: proteomic and biomechanical analysis of the canine intervertebral disc

(2015) William Mark Erwin et al.   ARTHRITIS RESEARCH & THERAPY

Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress

(2014) Jong-Soo Park et al.   INTERNATIONAL ORTHOPAEDICS

Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs

(2014) Louise E Clarke et al.   ARTHRITIS RESEARCH & THERAPY

Cell death in intervertebral disc degeneration

(2013) Fan Ding et al.   APOPTOSIS

Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs

(2013) Katherine D Hudson et al.   CURRENT OPINION IN BIOTECHNOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Prospective, Multicenter, Randomized, Controlled Study of Anular Repair in Lumbar Discectomy

(2013) Alexander Bailey et al.   SPINE

Genetic polymorphisms associated with intervertebral disc degeneration

(2013) Jillian E. Mayer et al.   Spine Journal

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral disc degeneration

(2012) Libo Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study

(2011) G. Livshits et al.   ANNALS OF THE RHEUMATIC DISEASES

Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats

(2011) Yue-Hui Zhang et al.   APOPTOSIS

Lumbar Intervertebral Disk Degeneration

(2011) Dino Samartzis et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Emerging Technologies for Molecular Therapy for Intervertebral Disk Degeneration

(2011) Won C. Bae et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

The Dog as an Animal Model for Intervertebral Disc Degeneration?

(2011) Niklas Bergknut et al.   SPINE

Injection of AAV2-BMP2 and AAV2-TIMP1 into the nucleus pulposus slows the course of intervertebral disc degeneration in an in vivo rabbit model

(2011) Steven K. Leckie et al.   Spine Journal

Porcine Intervertebral Disc Repair Using Allogeneic Juvenile Articular Chondrocytes or Mesenchymal Stem Cells

(2011) Frank L. Acosta et al.   TISSUE ENGINEERING PART A

Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study

(2011) Lluis Orozco et al.   TRANSPLANTATION

GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women

(2010) F. M. K. Williams et al.   ARTHRITIS AND RHEUMATISM

Association of the Polymorphisms of Vitamin D Receptor and Aggrecan Genes with Degenerative Disc Disease

(2010) Betul Eser et al.   Genetic Testing and Molecular Biomarkers

Leg Amputation Accelerates Senescence of Rat Lumbar Intervertebral Discs

(2010) Qiu-Juan Xing et al.   SPINE

Disc Regeneration Therapy Using Marrow Mesenchymal Cell Transplantation

(2010) Takafumi Yoshikawa et al.   SPINE

Transplantation of Goat Bone Marrow Stromal Cells to the Degenerating Intervertebral Discin a Goat Disc Injury Model

(2010) Yejia Zhang et al.   SPINE

Structured coculture of stem cells and disc cells prevent disc degeneration in a rat model

(2010) Aliza A. Allon et al.   Spine Journal

Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes

(2010) Peng Cao et al.   Spine Journal

Biologic Response of Human Intervertebral Disc Cells to Gene Therapy Cocktail

(2009) Seong-Hwan Moon et al.   SPINE

Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model

(2009) Shoji Seki et al.   ARTHRITIS RESEARCH & THERAPY

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

IGF-1 rescues human intervertebral annulus cells fromin vitrostress-induced premature senescence

(2008) Helen E. Gruber et al.   GROWTH FACTORS

The genetics of intervertebral disc degeneration.Familial predisposition and heritability estimation

(2008) Leonid Kalichman et al.   JOINT BONE SPINE

Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus

(2008) Helen E. Gruber et al.   Spine Journal