siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates

(2016) Rubina Parmar et al.   CHEMBIOCHEM

Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide

(2016) Nicole T. Schirle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex

(2015) Shintaro Iwasaki et al.   NATURE

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

(2015) Alfica Sehgal et al.   NATURE MEDICINE

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity

(2015) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

(2015) Amy Chan et al.   Molecular Therapy-Nucleic Acids

Allele-Selective Inhibition of Mutant Atrophin-1 Expression by Duplex and Single-Stranded RNAs

(2014) Jiaxin Hu et al.   BIOCHEMISTRY

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

Lipid Nanoparticles Improve Activity of Single-Stranded siRNA and Gapmer Antisense Oligonucleotides in Animals

(2013) Thazha P. Prakash et al.   ACS Chemical Biology

Argonaute2 expression is post-transcriptionally coupled to microRNA abundance

(2013) N. J. Martinez et al.   RNA

Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity

(2013) Kotaro Nakanishi et al.   Cell Reports

The Making of a Slicer: Activation of Human Argonaute-1

(2013) Christopher R. Faehnle et al.   Cell Reports

Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties

(2012) Liang Meng Wee et al.   CELL

Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

(2012) Dongbo Yu et al.   CELL

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

Single-Stranded siRNAs Activate RNAi in Animals

(2012) Walt F. Lima et al.   CELL

Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses

(2012) S. H. Olejniczak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Unique Gene-Silencing and Structural Properties of 2′-Fluoro-Modified siRNAs

(2011) Muthiah Manoharan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

(2011) Filipp Frank et al.   EMBO REPORTS

Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein

(2011) A. Boland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein

(2010) Andreas Boland et al.   EMBO REPORTS

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

Quantitative evaluation of siRNA delivery in vivo

(2010) Y. Pei et al.   RNA

Binding and Cleavage Specificities of Human Argonaute2

(2009) Walt F. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY