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Therapeutic targeting of microRNAs: current status and future challenges

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TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

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Prognostic Value of miR-21 in Various Cancers: An Updating Meta-Analysis

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Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth

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Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Diversifying microRNA sequence and function

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miRBase: annotating high confidence microRNAs using deep sequencing data

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4-HNE Increases Intracellular ADMA Levels in Cultured HUVECs: Evidence for miR-21-Dependent Mechanisms

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Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

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MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

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MicroRNAs in Common Human Diseases

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Chemical modification and design of anti-miRNA oligonucleotides

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Comparison of different miR-21 inhibitor chemistries in a cardiac disease model

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Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

(2011) Erich Koller et al.   NUCLEIC ACIDS RESEARCH

Apoptosis and the target genes of microRNA-21

(2011) Lindsey E. Becker Buscaglia et al.   Chinese Journal of Cancer

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miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2′-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN

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(2009) Richard S Geary   Expert Opinion on Drug Metabolism & Toxicology

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

(2009) C. A. Stein et al.   NUCLEIC ACIDS RESEARCH

The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE