标题
Genetics meets proteomics: perspectives for large population-based studies
作者
关键词
-
出版物
NATURE REVIEWS GENETICS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-08-28
DOI
10.1038/s41576-020-0268-2
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Influence of Genetic Ancestry on Human Serum Proteome
- (2020) Jennifer Sjaarda et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
- (2020) Mathias Uhlen et al. SCIENCE
- Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
- (2020) Shaza B. Zaghlool et al. Nature Communications
- Beyond mass spectrometry, the next step in proteomics
- (2020) Winston Timp et al. Science Advances
- Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes
- (2020) Valborg Gudmundsdottir et al. DIABETES
- Consistent RNA sequencing contamination in GTEx and other data sets
- (2020) Tim O. Nieuwenhuis et al. Nature Communications
- Probing the Virtual Proteome to Identify Novel Disease Biomarkers
- (2019) Jonathan D. Mosley et al. CIRCULATION
- Opportunities and challenges for transcriptome-wide association studies
- (2019) Michael Wainberg et al. NATURE GENETICS
- Glycoproteogenomics: a frequent gene polymorphism affects the glycosylation pattern of the human serum fetuin/α-2-HS-glycoprotein
- (2019) Yu-Hsien Lin et al. MOLECULAR & CELLULAR PROTEOMICS
- Analysis of 1508 plasma samples by capillary flow data-independent acquisition profiles proteomics of weight loss and maintenance
- (2019) Roland Bruderer et al. MOLECULAR & CELLULAR PROTEOMICS
- An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
- (2019) Tom G Richardson et al. eLife
- In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta
- (2019) Maria Pernemalm et al. eLife
- Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome
- (2019) Michael Chong et al. CIRCULATION
- Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
- (2019) Eeva Sliz et al. JOURNAL OF MEDICAL GENETICS
- Small-protein enrichment assay enables the rapid, unbiased analysis of over 100 low abundance factors from human plasma
- (2019) Dylan Harney et al. MOLECULAR & CELLULAR PROTEOMICS
- Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
- (2019) Robert F. Hillary et al. Nature Communications
- Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles
- (2019) Claudia Fredolini et al. Scientific Reports
- Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome
- (2019) Karsten Suhre et al. Metabolites
- Identifying and Validating New Drug Targets for Stroke and Beyond
- (2019) Andrew Plump et al. CIRCULATION
- Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies
- (2019) Philipp E Geyer et al. EMBO Molecular Medicine
- Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach
- (2019) Jaclyn R. Daniels et al. JOURNAL OF PROTEOME RESEARCH
- A dream of single-cell proteomics
- (2019) Vivien Marx NATURE METHODS
- Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data
- (2019) Vera Ignjatovic et al. JOURNAL OF PROTEOME RESEARCH
- The human secretome
- (2019) Mathias Uhlén et al. Science Signaling
- Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
- (2019) Tianxiao Huan et al. Nature Communications
- Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma
- (2019) Johannes Graumann et al. Frontiers in Oncology
- Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy
- (2019) Artika P. Nath et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Plasma protein patterns as comprehensive indicators of health
- (2019) Stephen A. Williams et al. NATURE MEDICINE
- Undulating changes in human plasma proteome profiles across the lifespan
- (2019) Benoit Lehallier et al. NATURE MEDICINE
- MoDentify: phenotype-driven module identification in metabolomics networks at different resolutions
- (2018) Kieu Trinh Do et al. BIOINFORMATICS
- Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays
- (2018) Qiujin Shen et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- IL8 and IL16 levels indicate serum and plasma quality
- (2018) Olga Kofanova et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
- (2018) Shaza B Zaghlool et al. HUMAN MOLECULAR GENETICS
- How many human proteoforms are there?
- (2018) Ruedi Aebersold et al. Nature Chemical Biology
- Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
- (2018) Eric R. Gamazon et al. NATURE GENETICS
- Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
- (2018) Etienne Patin et al. NATURE IMMUNOLOGY
- The MR-Base platform supports systematic causal inference across the human phenome
- (2018) Gibran Hemani et al. eLife
- Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project
- (2018) Gilbert S. Omenn et al. JOURNAL OF PROTEOME RESEARCH
- Data‐independent acquisition‐based SWATH‐MS for quantitative proteomics: a tutorial
- (2018) Christina Ludwig et al. Molecular Systems Biology
- Genomic atlas of the human plasma proteome
- (2018) Benjamin B. Sun et al. NATURE
- Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome
- (2018) Daria V. Zhernakova et al. NATURE GENETICS
- Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
- (2018) Amit V. Khera et al. NATURE GENETICS
- Co-regulatory networks of human serum proteins link genetics to disease
- (2018) Valur Emilsson et al. SCIENCE
- Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
- (2018) Miriam S. Udler et al. PLOS MEDICINE
- The UK Biobank resource with deep phenotyping and genomic data
- (2018) Clare Bycroft et al. NATURE
- Enhanced validation of antibodies for research applications
- (2018) Fredrik Edfors et al. Nature Communications
- Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study
- (2017) Paul S. de Vries et al. HUMAN MOLECULAR GENETICS
- The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays
- (2017) Jochen M. Schwenk et al. JOURNAL OF PROTEOME RESEARCH
- Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells
- (2017) Anja M. Billing et al. Journal of Proteomics
- Revisiting biomarker discovery by plasma proteomics
- (2017) Philipp E Geyer et al. Molecular Systems Biology
- Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS
- (2017) George Rosenberger et al. NATURE BIOTECHNOLOGY
- PECAN: library-free peptide detection for data-independent acquisition tandem mass spectrometry data
- (2017) Ying S Ting et al. NATURE METHODS
- WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research
- (2017) Denise N Slenter et al. NUCLEIC ACIDS RESEARCH
- Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
- (2017) Jérôme Carayol et al. Nature Communications
- The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases
- (2017) Muhammad Ahsan et al. PLoS Genetics
- Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
- (2017) Lasse Folkersen et al. PLoS Genetics
- High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors
- (2017) Antonio F. Di Narzo et al. PLoS Genetics
- Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk FactorCLINICAL PERSPECTIVE
- (2017) Derek Klarin et al. Circulation-Cardiovascular Genetics
- Genetic Architecture of the Cardiovascular Risk Proteome
- (2017) Mark D. Benson et al. CIRCULATION
- Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease
- (2017) Pim van der Harst et al. CIRCULATION RESEARCH
- PhenoScanner: a database of human genotype–phenotype associations
- (2016) James R. Staley et al. BIOINFORMATICS
- Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?Response to Harper et al
- (2016) Shavonn C. Harper et al. CIRCULATION RESEARCH
- Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of Twenty Cardiovascular-Related Proteins: The Tromsø Study
- (2016) Terry Solomon et al. Circulation-Cardiovascular Genetics
- Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease
- (2016) Peter Ganz et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems
- (2016) Maggie P. Y. Lam et al. JOURNAL OF PROTEOME RESEARCH
- Proteomics reveals the effects of sustained weight loss on the human plasma proteome
- (2016) Philipp E Geyer et al. Molecular Systems Biology
- Mass-spectrometric exploration of proteome structure and function
- (2016) Ruedi Aebersold et al. NATURE
- A proposal for validation of antibodies
- (2016) Mathias Uhlen et al. NATURE METHODS
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
- (2016) Jacqueline MacArthur et al. NUCLEIC ACIDS RESEARCH
- The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
- (2016) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of Twenty Cardiovascular-Related Proteins: The Tromsø Study
- (2016) Terry Solomon et al. Circulation-Cardiovascular Genetics
- Plasma Proteome Profiling to Assess Human Health and Disease
- (2016) Philipp E. Geyer et al. Cell Systems
- Effects of Long-Term Storage Time and Original Sampling Month on Biobank Plasma Protein Concentrations
- (2016) Stefan Enroth et al. EBioMedicine
- Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
- (2016) Yuetiva Deming et al. Scientific Reports
- Immunocapture strategies in translational proteomics
- (2015) Claudia Fredolini et al. Expert Review of Proteomics
- Genetics of human metabolism: an update
- (2015) Gabi Kastenmüller et al. HUMAN MOLECULAR GENETICS
- Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury
- (2015) Hasmik Keshishian et al. MOLECULAR & CELLULAR PROTEOMICS
- Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma
- (2015) Susan E. Abbatiello et al. MOLECULAR & CELLULAR PROTEOMICS
- Quantitative variability of 342 plasma proteins in a human twin population
- (2015) Y. Liu et al. Molecular Systems Biology
- Reproducibility crisis: Blame it on the antibodies
- (2015) Monya Baker NATURE
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- SNiPA: an interactive, genetic variant-centered annotation browser
- (2014) Matthias Arnold et al. BIOINFORMATICS
- The German National Cohort: aims, study design and organization
- (2014) EUROPEAN JOURNAL OF EPIDEMIOLOGY
- A draft map of the human proteome
- (2014) Min-Sik Kim et al. NATURE
- Proteogenomic characterization of human colon and rectal cancer
- (2014) Bing Zhang et al. NATURE
- Mass-spectrometry-based draft of the human proteome
- (2014) Mathias Wilhelm et al. NATURE
- An atlas of genetic influences on human blood metabolites
- (2014) So-Youn Shin et al. NATURE GENETICS
- Proteogenomics: concepts, applications and computational strategies
- (2014) Alexey I Nesvizhskii NATURE METHODS
- The role of glycosylation in IBD
- (2014) Evropi Theodoratou et al. Nature Reviews Gastroenterology & Hepatology
- Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability
- (2014) Erika Assarsson et al. PLoS One
- Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs
- (2014) Stefan Enroth et al. Nature Communications
- Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
- (2014) John S. K. Kauwe et al. PLoS Genetics
- Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS
- (2013) Xin He et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genetic Variants Regulating Immune Cell Levels in Health and Disease
- (2013) Valeria Orrù et al. CELL
- Profiling post-centrifugation delay of serum and plasma with antibody bead arrays
- (2013) Ulrika Qundos et al. Journal of Proteomics
- Method and platform standardization in MRM-based quantitative plasma proteomics
- (2013) Andrew J. Percy et al. Journal of Proteomics
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- Identification of genetic variants influencing the human plasma proteome
- (2013) A. Johansson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
- (2012) Ann-Kristin Petersen et al. BMC BIOINFORMATICS
- Affinity proteomics: the role of specific binding reagents in human proteome analysis
- (2012) Oda Stoevesandt et al. Expert Review of Proteomics
- Identification of cis-regulatory variation influencing protein abundance levels in human plasma
- (2012) Anbarasu Lourdusamy et al. HUMAN MOLECULAR GENETICS
- Global Stability of Plasma Proteomes for Mass Spectrometry-Based Analyses
- (2012) Lisa J. Zimmerman et al. MOLECULAR & CELLULAR PROTEOMICS
- Mass spectrometry–based targeted proteomics
- (2012) Allison Doerr NATURE METHODS
- Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses
- (2012) Oliver Stegle et al. Nature Protocols
- Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
- (2011) Jan Krumsiek et al. BMC Systems Biology
- Systematic antibody and antigen-based proteomic profiling with microarrays
- (2011) Burcu Ayoglu et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up
- (2011) Z. Chen et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Human metabolic individuality in biomedical and pharmaceutical research
- (2011) Karsten Suhre et al. NATURE
- Principles for the post-GWAS functional characterization of cancer risk loci
- (2011) Matthew L Freedman et al. NATURE GENETICS
- A roadmap to generate renewable protein binders to the human proteome
- (2011) Karen Colwill et al. NATURE METHODS
- Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations
- (2010) David M Rissin et al. NATURE BIOTECHNOLOGY
- The Clinical Plasma Proteome: A Survey of Clinical Assays for Proteins in Plasma and Serum
- (2009) N. L. Anderson CLINICAL CHEMISTRY
- Pre-analytical operating procedures for serum Low Molecular Weight protein profiling
- (2009) Francesco Di Girolamo et al. Journal of Proteomics
- Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma
- (2009) Terri A Addona et al. NATURE BIOTECHNOLOGY
- A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
- (2008) David Melzer et al. PLoS Genetics
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