标题
Fatty Acid Synthase: An Emerging Target in Cancer
作者
关键词
-
出版物
MOLECULES
Volume 25, Issue 17, Pages 3935
出版商
MDPI AG
发表日期
2020-08-28
DOI
10.3390/molecules25173935
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis
- (2020) Li Gu et al. ONCOGENE
- Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines
- (2020) Iara Gonçalves de Aquino et al. ARCHIVES OF ORAL BIOLOGY
- FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits
- (2020) Megan Bowers et al. Cell Stem Cell
- SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract
- (2020) Andrea Floris et al. Biomolecules
- Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation
- (2019) Choong-kun Lee et al. SCIENCE
- CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway
- (2019) Jiaomeng Pan et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells
- (2019) Bang-Jau You et al. CHEMICAL RESEARCH IN TOXICOLOGY
- High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma
- (2019) Young-Sik Kim et al. DISEASE MARKERS
- Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway
- (2019) Ligong Chang et al. Lipids in Health and Disease
- FASN activity is important for the initial stages of the induction of senescence
- (2019) Juan Fafián-Labora et al. Cell Death & Disease
- In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation
- (2019) ALEKSANDRA CZUMAJ et al. ANTICANCER RESEARCH
- De novo lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion. Implications for combined chemotherapy
- (2019) Luciana Rodriguez Sawicki et al. CELL CYCLE
- Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
- (2019) Kuei-Pin Chung et al. Nature Communications
- Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line
- (2019) Giorgia Cioccoloni et al. JOURNAL OF CHEMOTHERAPY
- In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
- (2019) Milica Momcilovic et al. NATURE
- Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway
- (2019) Hui-Yen Chuang et al. Scientific Reports
- Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non‐small cell lung cancer
- (2018) Azhar Ali et al. EMBO Molecular Medicine
- Diverse roles of fatty acid binding proteins (FABPs) in development and pathogenesis of cancers
- (2018) Mina Amiri et al. GENE
- The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model
- (2018) Efthymia Papaevangelou et al. INTERNATIONAL JOURNAL OF CANCER
- CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
- (2018) Ying-nan Wang et al. ONCOGENE
- Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis
- (2018) Andras Ladanyi et al. ONCOGENE
- Inhibition of FASN expression enhances radiosensitivity in human non-small cell lung cancer
- (2018) Ning Zhan et al. Oncology Letters
- Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins
- (2018) Maomao Zhang et al. Cancer Discovery
- Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer
- (2018) Yekaterina Y. Zaytseva et al. Oncotarget
- Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States
- (2018) Dongya Jia et al. Cells
- Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis
- (2018) Ting Tao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells
- (2018) Meng-Chi Yen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells
- (2018) Yu Liang et al. Oncogenesis
- Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells
- (2017) Clayton Wright et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression
- (2017) Jiangman Duan et al. ONCOLOGY REPORTS
- Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma
- (2017) Arvin M. Gouw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma
- (2017) Tingting Chen et al. Oncology Letters
- Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells
- (2017) J A Menendez et al. Oncogenesis
- Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions
- (2017) Chuanling Zhang et al. Scientific Reports
- Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth
- (2016) Huai-Peng Lin et al. CANCER RESEARCH
- Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors
- (2016) Thelma S. Angeles et al. Expert Opinion on Drug Discovery
- Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid–Induced Macrophage Cell Death through Enhancing Ceramide Production
- (2016) Yuwen Zhang et al. JOURNAL OF IMMUNOLOGY
- The role of ER stress in lipid metabolism and lipotoxicity
- (2016) Jaeseok Han et al. JOURNAL OF LIPID RESEARCH
- FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration
- (2016) LAN ZHOU et al. ONCOLOGY REPORTS
- FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1
- (2016) Xi Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer
- (2016) Jun Hyoung Park et al. Cell Reports
- High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells
- (2016) Koichiro Kawaguchi et al. FEBS Open Bio
- Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers
- (2016) Aritro Nath et al. Scientific Reports
- Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer
- (2015) Yong Bian et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway
- (2015) Ligong Chang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
- (2015) Michal Pawlak et al. JOURNAL OF HEPATOLOGY
- Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
- (2015) Anneleen Daemen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
- (2015) Jade Mims et al. RADIATION RESEARCH
- Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration
- (2015) Yekaterina Y. Zaytseva et al. Oncotarget
- Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer
- (2015) Karthic Chandran et al. Oncotarget
- Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells
- (2015) Graziela Rosa Ravacci et al. Biomed Research International
- Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression
- (2015) Richard Ventura et al. EBioMedicine
- Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer
- (2015) Deliang Guo et al. CURRENT PHARMACEUTICAL DESIGN
- Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma
- (2015) Aritro Nath et al. Scientific Reports
- Novel Nuclear Localization of Fatty Acid Synthase Correlates with Prostate Cancer Aggressiveness
- (2014) Allison A. Madigan et al. AMERICAN JOURNAL OF PATHOLOGY
- Fatty acid synthase is required for mammary gland development and milk production during lactation
- (2014) Janel Suburu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells
- (2014) Lakshmi Reddy Bollu et al. CELL CYCLE
- De novo fatty acid synthesis at the mitotic exit is required to complete cellular division
- (2014) Natalia Scaglia et al. CELL CYCLE
- Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression
- (2014) Hisanori Uehara et al. INTERNATIONAL JOURNAL OF CANCER
- Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
- (2014) Susanne Grube et al. JOURNAL OF NEURO-ONCOLOGY
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- (2014) Valerie S. LeBleu et al. NATURE CELL BIOLOGY
- In Situ Proteome Profiling of C75, a Covalent Bioactive Compound with Potential Anticancer Activities
- (2014) Xiamin Cheng et al. ORGANIC LETTERS
- The mTOR Inhibitor Rapamycin Synergizes with a Fatty Acid Synthase Inhibitor to Induce Cytotoxicity in ER/HER2-Positive Breast Cancer Cells
- (2014) Chen Yan et al. PLoS One
- Inhibition of fatty acid synthase suppresses U-2 OS cell invasion and migration via downregulating the activity of HER2/PI3K/AKT signaling pathway in vitro
- (2013) Tao Fang Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma
- (2013) HENG WANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells
- (2013) RISA SHIRAGAMI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα
- (2013) Anne P. L. Jensen-Urstad et al. JOURNAL OF LIPID RESEARCH
- The Fatty Acid Synthase Inhibitor Orlistat Reduces the Growth and Metastasis of Orthotopic Tongue Oral Squamous Cell Carcinomas
- (2013) M. Agostini et al. MOLECULAR CANCER THERAPEUTICS
- Fatty Acid Synthase Inhibition Induces Differential Expression of Genes Involved in Apoptosis and Cell Proliferation in Ocular Cancer Cells
- (2013) Perinkulam Ravi Deepa et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Fatty Acid Synthase Is a Potential Therapeutic Target in Estrogen Receptor-/Progesterone Receptor-Positive Endometrioid Endometrial Cancer
- (2013) Mohammed Tanjimur Rahman et al. ONCOLOGY
- Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation
- (2013) Shiva Kant et al. PLoS One
- Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules
- (2012) Shiva Kant et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer
- (2012) Joana Relat et al. BMC CANCER
- The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
- (2012) F Seguin et al. BRITISH JOURNAL OF CANCER
- Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy
- (2012) Madhuri Sankaranarayanapillai et al. MOLECULAR IMAGING AND BIOLOGY
- Blockade of Fatty Acid Synthase Triggers Significant Apoptosis in Mantle Cell Lymphoma
- (2012) Pascal Gelebart et al. PLoS One
- Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma
- (2012) A. P. Bhatt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model
- (2012) H-W Chen et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer
- (2012) Bo Jiang et al. UROLOGY
- A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells
- (2011) Nan Hu et al. ACTA PHARMACOLOGICA SINICA
- Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?
- (2011) Anne P.L. Jensen-Urstad et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Fatty acid binding proteins (FABPs) in prostate, bladder and kidney cancer cell lines and the use of IL-FABP as survival predictor in patients with renal cell carcinoma
- (2011) Angelika Tölle et al. BMC CANCER
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Identification of a New Fatty Acid Synthesis-Transport Machinery at the Peroxisomal Membrane
- (2011) Merle Hillebrand et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Roles of Peroxisome Proliferator–Activated Receptor–α and –γ in the Development of Non–Small Cell Lung Cancer
- (2010) Ming-Yue Li et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Mitochondrial fatty acid synthesis and respiration
- (2010) J. Kalervo Hiltunen et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase
- (2010) Dolores Di Vizio et al. CELL CYCLE
- Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress
- (2010) Tracie A. Seimon et al. Cell Metabolism
- Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells
- (2010) A. Vazquez-Martin et al. CELL PROLIFERATION
- Fatty acid synthase as a potential therapeutic target in cancer
- (2010) Richard Flavin et al. Future Oncology
- CD36 Is a Novel Serum Amyloid A (SAA) Receptor Mediating SAA Binding and SAA-induced Signaling in Human and Rodent Cells
- (2010) Irina N. Baranova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis
- (2010) Karina G Zecchin et al. LABORATORY INVESTIGATION
- Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma
- (2010) S. Uddin et al. MOLECULAR CANCER THERAPEUTICS
- Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients
- (2009) Menendez INTERNATIONAL JOURNAL OF ONCOLOGY
- EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
- (2009) D. Guo et al. Science Signaling
- Transcriptional control of mitochondrial biogenesis: the central role of PGC-1
- (2008) R. Ventura-Clapier et al. CARDIOVASCULAR RESEARCH
- UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators
- (2008) D. Thomas Rutkowski et al. DEVELOPMENTAL CELL
- Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
- (2008) Marco A. Carvalho et al. INTERNATIONAL JOURNAL OF CANCER
- Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
- (2008) Masato Furuhashi et al. NATURE REVIEWS DRUG DISCOVERY
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