Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway

Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression

(2019) Fu-Ju Chou et al.   EBioMedicine

Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy

(2018) Alejandro Schcolnik-Cabrera et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Androgen Receptor Signaling Reduces Radiosensitivity in Bladder Cancer

(2018) Hiroki Ide et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

(2018) Giorgia Zadra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition

(2016) Prahlad V. Raninga et al.   CELL CYCLE

Cell cycle-coupled expansion of AR activity promotes cancer progression

(2016) C McNair et al.   ONCOGENE

Molecular mechanisms underlying resistance to androgen deprivation therapy in prostate cancer

(2016) Kristine M. Wadosky et al.   Oncotarget

Diet-induced alteration of fatty acid synthase in prostate cancer progression

(2016) M Huang et al.   Oncogenesis

Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation

(2015) D. E. Spratt et al.   CANCER RESEARCH

Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy

(2015) Colin Rae et al.   RADIATION RESEARCH

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair

(2015) Firas L. Tarish et al.   Science Translational Medicine

Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo

(2015) Fei-Ting Hsu et al.   Scientific Reports

The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

(2015) Martin C. Sadowski et al.   Oncotarget

Capsaicin: A novel radio-sensitizing agent for prostate cancer

(2014) Natalie A. Venier et al.   PROSTATE

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

(2014) Karim Bensaad et al.   Cell Reports

Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G1 to S Phase

(2013) Shalini Murthy et al.   PLoS One

The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas

(2012) F Seguin et al.   BRITISH JOURNAL OF CANCER

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model

(2012) H-W Chen et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

(2012) Benjamin W. Turney et al.   RADIOTHERAPY AND ONCOLOGY

Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)

(2012) Puspa R. Pandey et al.   Recent Patents on Anti-Cancer Drug Discovery

Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma

(2012) Yu-Chien Kao et al.   TUMOR BIOLOGY

Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal

(2011) Hui-Yen Chuang et al.   BIOMEDICINE & PHARMACOTHERAPY

Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-κB expression in vitro and in vivo

(2011) Yu-Cheng Kuo et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunomodulation of Curcumin on Adoptive Therapy with T Cell Functional Imaging in Mice

(2011) Y.-F. Chang et al.   Cancer Prevention Research

Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

(2011) A J Cockbain et al.   GUT

The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation

(2010) Justine Rudner et al.   Radiation Oncology

Prostate Cancer Screening

(2010) Elise D. Cook et al.   Current Oncology Reports

Curcumin Modulates the Radiosensitivity of Colorectal Cancer Cells by Suppressing Constitutive and Inducible NF-κB Activity

(2009) Santosh K. Sandur et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Therapeutic Efficacy Evaluation of 111In-Labeled PEGylated Liposomal Vinorelbine in Murine Colon Carcinoma with Multimodalities of Molecular Imaging

(2009) T.-H. Chow et al.   JOURNAL OF NUCLEAR MEDICINE

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

(2009) Hui-Fang Li et al.   Radiation Oncology

Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

(2008) Marco A. Carvalho et al.   INTERNATIONAL JOURNAL OF CANCER