Article
Biochemistry & Molecular Biology
Nada F. Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H. Eisa
Summary: The study demonstrates that quinacrine alleviates cisplatin-induced renal toxicity by upregulating SIRT-1, downregulating inflammatory markers (ICAM-1 and TNF-alpha), reducing oxidative stress, and inhibiting apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Lamiaa Abellatef Ali Barakat, Ibrahim Mohy El-Deen, Manar Abdo El-Zend, Mohammed El-Behery
Summary: This study designed, synthesized and evaluated a series of novel anticancer derivatives, and assessed their cytotoxicity and apoptotic activity. Among them, compound 3b showed high cytotoxicity and induced cell cycle arrest and apoptosis.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Sally A. Habib, Ghada M. Suddek, Mona Abdel Rahim, Rehab S. Abdelrahman
Summary: The study demonstrates that Protocatechuic acid (Proto) has a protective effect against cisplatin-induced hepatotoxicity in female albino mice. Proto effectively attenuates liver function changes caused by cisplatin through its antioxidant, anti-inflammatory, and anti-apoptotic effects.
Article
Veterinary Sciences
Tarek Kamal Abouzed, Eman Abd Elrahman Sherif, Mohamed El Sayed Barakat, Kadry Mohamed Sadek, Adil Aldhahrani, Nasr Elsayed Nasr, Ehab Eldomany, Khaled Khailo, Doaa Abdallha Dorghamm
Summary: This experiment identified early signs of nephrotoxicity induced by gentamicin and cisplatin in rats, with cisplatin showing greater nephrotoxic effects compared to gentamicin. The study suggests the use of necrotic, apoptotic genes as early biomarkers in detecting kidney damage, and recommends caution when co-administering cisplatin with gentamicin.
BMC VETERINARY RESEARCH
(2021)
Article
Environmental Sciences
Na Fu, Wenmei Li, Guanghai Liu, Jie Yu, Jie Xu
Summary: The study revealed that NP exposure led to increased expression of Bax and Caspase-3 in adipose tissue of rats and 3T3-L1 preadipocytes, as well as accumulation of lipid droplets.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2021)
Article
Biochemistry & Molecular Biology
Mohammad Z. Ahmed, Fahd A. Nasr, Wajhul Qamar, Omar M. Noman, Javed Masood Khan, Abdullah A. Al-Mishari, Ali S. Alqahtani
Summary: The study showed that janerin inhibits THP-1 cell proliferation in a dose-dependent manner by causing cell cycle arrest at the G2/M phase. Additionally, janerin promotes THP-1 cell death through apoptosis induction, which involves upregulation of pro-apoptotic markers and downregulation of anti-apoptotic marker. Furthermore, janerin treatment leads to the activation of P38-MAPK and ERK1/2 signaling pathways, suggesting its potential as a therapeutic agent for leukemia.
Article
Pharmacology & Pharmacy
Tonghui Li, Liuliu Shi, Wenqiang Liu, Xuhao Hu, Yuanjian Hui, Maojun Di, Shen Xue, Yan Zheng, Mengjuan Yao, Chen Li, Kun Meng
Summary: This study reveals the potential of aloe-emodin to induce pyroptosis, a new form of cell death. The researchers also identify the molecular mechanisms involved and explore the changes in cellular pathways caused by aloe-emodin. These findings provide a theoretical basis for utilizing anthraquinone derivatives in the treatment of GSDME-expressing cancers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xin Cao, Sisi Peng, Ying Yan, Jun Li, Jianping Zhou, Hongwei Dai, Jie Xu
Summary: Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease driven by inflammation, and synoviocytes are important inflammatory factor releasers. Inhibiting RIPK1 can suppress inflammation and cell death, protecting articular cartilage in TMJOA.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xiaomei Luo, Yuanyuan Li, Bingdian Wang, Sai Zhu, Xinran Liu, Xueqi Liu, Xiangming Qi, Yonggui Wu
Summary: This study investigated the protective effect of carnosine on renal tubule cells in AKI. The results showed that carnosine reduced inflammation and pyroptosis by targeting caspase-1, highlighting its potential as a therapeutic agent for AKI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Stephanie McKenna, Lucia Garcia-Gutierrez, David Matallanas, Dirk Fey
Summary: The article discussed the core mechanism of apoptosis initiation and how BAX and SMAC control the apoptotic switch. Through mathematical modeling and experimental verification, it was found that BAX and SMAC play crucial roles in regulating the apoptotic switch and its importance.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yu-Kai Huang, Kun-Che Chang, Chia-Yang Li, Ann-Shung Lieu, Chih-Lung Lin
Summary: This study investigated the role of AKR1B1 in glioma cell proliferation and apoptosis signaling. AKR1B1 expression was measured in different cell lines and tissues. The effects of AKR1B1 overexpression or knockdown, as well as p38 MAPK activation and inhibition, were evaluated. AKR1B1 was found to regulate glioma cell proliferation through the activation of p38 MAPK and apoptosis signaling. Therefore, AKR1B1 may be a potential therapeutic target for glioma therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Immunology
Shuling Zhang, Ning Liu, Mingxing Ma, Hai Huang, Mike Handley, Xueli Bai, Fengping Shan
Summary: The study demonstrated that MENK regulates the biological behavior of lung cancer cells by enhancing apoptosis and immunogenicity while promoting NK cell-driven tumor immunity, potentially inhibiting the proliferation of lung cancer cells through the activation of key signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Bin Xue, Bei Zhao, Shuangyan Luo, Gang Wu, Xiaodan Hui
Summary: In this study, oat bran was enriched with blackcurrant and blueberry powder to form paste extracts, which were found to significantly inhibit the growth and invasion of hepatocellular carcinoma cells. Mechanistic studies suggested that these extracts induced cell apoptosis through cell cycle arrest and regulation of apoptotic-related protein expressions. The extracts also increased reactive oxygen species levels in the cancer cells via the Nrf2/HO1 signaling pathway. These findings highlight the therapeutic potential of blueberry and blackcurrant-enriched oat bran paste for patients with liver cancer.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Qinghan Ren, Guoquan Zhang, Ruiting Yan, Dezheng Zhou, Li Huang, Qianwen Zhang, Wen Li, Guowei Huang, Zhenshu Li, Jing Yan
Summary: Research has shown that folate deficiency in either parents can affect the biological functions of neural cells in offspring. This deficiency can impair the methionine cycle and lead to damage to the central nervous system. The study found that parental folate deficiency caused apoptosis of neural cells in neonatal rats, with the greatest effect seen when both parents were deficient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Umiey Fahietah Mohd Fisall, Noor Zafirah Ismail, Ismail Abiola Adebayo, Hasni Arsad
Summary: The study investigated the cytotoxic and apoptotic effects of Moringa oleifera leaf extract on breast cancer cells. The dichloromethane extract showed selective cytotoxicity towards MCF7 cells without affecting non-cancerous cells, inducing early apoptosis and increasing the expressions of pro-apoptotic proteins. Gas chromatography-mass spectrometry analysis revealed the presence of key compounds contributing to the extract's anti-proliferative effects on cancer cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wang
Article
Medicine, Research & Experimental
Zhongfang Zhao, Ying Han, Zhihui Zhang, Wenwen Li, Xiaoli Ji, Xiaodan Liu, Jianqiu Jin, Si Xu, Hongmei Cui, Zhe Cheng, Qian Wang, Xing Wang, Xiang Guo, Yixiang Wang, Hongwei Liu
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Oncology
Li Zeng, Na Zhao, Fang Li, Dong Han, Yang Liu, Haochen Liu, Shichen Sun, Yixiang Wang, Hailan Feng
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Cell Biology
Li Zeng, Shichen Sun, Dong Han, Yang Liu, Haochen Liu, Hailan Feng, Yixiang Wang
CELLULAR SIGNALLING
(2018)
Article
Dentistry, Oral Surgery & Medicine
Li Zeng, Jiahui Wei, Na Zhao, Shichen Sun, Yixiang Wang, Hailan Feng
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Chemistry, Analytical
Lixing Liu, Beiyuan Fan, Diancan Wang, Xiufeng Li, Yeqing Song, Ting Zhang, Deyong Chen, Yixiang Wang, Junbo Wang, Jian Chen
Article
Pharmacology & Pharmacy
Zewen Han, Qingxiang Li, Yifei Wang, Lin Wang, Xiaoxu Li, Na Ge, Yixiang Wang, Chuanbin Guo
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Oncology
Wenwen Li, Ying Han, Zhongfang Zhao, Xiaoli Ji, Xing Wang, Jianqiu Jin, Qian Wang, Xiang Guo, Zhe Cheng, Mingxing Lu, Guodong Wang, Yixiang Wang, Hongwei Liu
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Cell & Tissue Engineering
Xiaoxia Li, Jing Xie, Yue Zhai, Tengjiaozi Fang, Nanquan Rao, Shuang Hu, Liping Yang, Yuming Zhao, Yixiang Wang, Lihong Ge
STEM CELLS INTERNATIONAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Juan Liu, Yixiang Wang, Huanxin Meng, Jingting Yu, Hongye Lu, Wenjing Li, Ruifang Lu, Yibing Zhao, Qiqiang Li, Li Su
JOURNAL OF CLINICAL PERIODONTOLOGY
(2019)
Article
Cell Biology
Yidi Wang, Yue Liu, Haotian Chen, Xiaojing Liu, Yi Zhang, Yixiang Wang, Yan Gu
Summary: In this study, FGFR2 mutation p.Cys342Arg was found to promote osteogenesis by enhancing mitochondrial metabolism-mediated FGF/FGFR-AMPK-Erk1/2 signaling pathway. This finding suggests the potential of targeting AMPK or Erk1/2 for the treatment of syndromic craniosynostosis.
Article
Cell Biology
Yuejiao Xin, Yang Liu, Jie Li, Dandan Liu, Chenying Zhang, Yixiang Wang, Shuguo Zheng
Summary: This study identified a novel osteoclast-specific lncRNA (OC-lncRNA) in CCD, which positively regulated osteoclastogenesis and bone resorption by competitively binding to miR-221-5p and promoting the expression of CXCR3. These findings uncover the underlying mechanism of OC-lncRNA-mediated osteoclast dysfunction in the delayed tooth eruption of CCD.
Article
Medicine, Research & Experimental
Xiaoxu Li, Ruiyu Ding, Zewen Han, Zeyun Ma, Yixiang Wang
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Medicine, Research & Experimental
Na Zhao, Li Zeng, Yang Liu, Dong Han, Haochen Liu, Jian Xu, Yuxi Jiang, Cuiying Li, Tao Cai, Hailan Feng, Yixiang Wang
Article
Dentistry, Oral Surgery & Medicine
Li Zeng, Na Zhao, Dong Han, Haochen Liu, Yang Liu, Yixiang Wang, Hailan Feng
ARCHIVES OF ORAL BIOLOGY
(2017)