期刊
CELL COMMUNICATION AND SIGNALING
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1478-811X-9-13
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资金
- NIH
- HHMI
- NIDCD [ZIA-DC-000016]
This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-kappa B, p53, and AKT pathways are summarized.
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