Extracellular Vesicles – Advanced Nanocarriers in Cancer Therapy: Progress and Achievements

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

(2019) Dnyaneshwar Kalyane et al.   Materials Science & Engineering C-Materials for Biological Applications

Embryonic Stem Cells‐Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

(2019) Qingwei Zhu et al.   Advanced Science

Harnessing Liposome Interactions With the Immune System for the Next Breakthrough in Cancer Drug Delivery

(2019) Ninh M. La-Beck et al.   Frontiers in Pharmacology

Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer

(2019) Tong Liu et al.   Molecular Cancer

Stem cell damage after chemotherapy- can we do better?

(2019) Joy Tang et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Milk exosomes - Natural nanoparticles for siRNA delivery

(2019) Farrukh Aqil et al.   CANCER LETTERS

Exosomes containing ErbB2/ CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer

(2019) Kazuhiko Yoshida et al.   CANCER SCIENCE

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Exosomes as Drug Carriers for Cancer Therapy

(2019) Jessica E. Pullan et al.   MOLECULAR PHARMACEUTICS

Genetically Engineered Cell Membrane Nanovesicles for Oncolytic Adenovirus Delivery: A Versatile Platform for Cancer Virotherapy

(2019) Peng Lv et al.   NANO LETTERS

Interfering with endolysosomal trafficking enhances release of bioactive exosomes

(2019) Francisco G. Ortega et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer

(2019) Guangzhi Li et al.   Small

Mesenchymal Stem Cell‐Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform

(2019) Gyuhyeon Baek et al.   Stem Cells Translational Medicine

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

(2019) Muhammad Asim Farooq et al.   Artificial Cells Nanomedicine and Biotechnology

Systematic review of targeted extracellular vesicles for drug delivery – Considerations on methodological and biological heterogeneity

(2019) Johann Mar Gudbergsson et al.   JOURNAL OF CONTROLLED RELEASE

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

(2019) Karin Steinbach et al.   Science Translational Medicine

Exosome DNA: Critical regulator of tumor immunity and a diagnostic biomarker

(2019) Aman Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy

(2019) Masamitsu Kanada et al.   MOLECULAR CANCER THERAPEUTICS

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

(2019) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Small extracellular vesicle loading systems in cancer therapy: Current status and the way forward

(2019) Yue-Feng Zhang et al.   CYTOTHERAPY

A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

(2019) Hongxiang Wei et al.   International Journal of Nanomedicine

Cocktail Strategy Based on NK Cell-Derived Exosomes and Their Biomimetic Nanoparticles for Dual Tumor Therapy

(2019) Wang et al.   Cancers

Exosomes: Versatile Nano Mediators of Immune Regulation

(2019) Li et al.   Cancers

Effects of Lyophilization of Arginine-rich Cell-penetrating Peptide-modified Extracellular Vesicles on Intracellular Delivery

(2019) KOSUKE NOGUCHI et al.   ANTICANCER RESEARCH

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

(2019) Ruoyu Cheng et al.   BIOMATERIALS

Extracellular Vesicles–Encapsulated MicroRNA-125b Produced in Genetically Modified Mesenchymal Stromal Cells Inhibits Hepatocellular Carcinoma Cell Proliferation

(2019) Silvia Baldari et al.   Cells

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

(2018) Max Piffoux et al.   ACS Nano

Drug delivery systems for programmed and on-demand release

(2018) Pooya Davoodi et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

(2018) Mark Barok et al.   BMC CANCER

Synthesis of dual temperature – and pH-responsive yolk-shell nanoparticles by conventional etching and new deswelling approaches: DOX release behavior

(2018) Goolia Nikravan et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dose-dense weekly chemotherapy in advanced ovarian cancer: An updated meta-analysis of randomized controlled trials

(2018) C. Marchetti et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

(2018) Gaofeng Liang et al.   International Journal of Nanomedicine

Characterization of exosomes derived from Toxoplasma gondii and their functions in modulating immune responses

(2018) Yawen Li et al.   International Journal of Nanomedicine

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

(2018) Yan Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial

(2018) Hai Wang et al.   ACS Central Science

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Therapeutic Potential of Mesenchymal Cell–Derived miRNA-150-5p–Expressing Exosomes in Rheumatoid Arthritis Mediated by the Modulation of MMP14 and VEGF

(2018) Zhe Chen et al.   JOURNAL OF IMMUNOLOGY

Exosomes produced from three-dimensional cultures of mesenchymal stem cells by tangential flow filtration show higher yield and improved activity

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

nCVTs: a hybrid smart tumour targeting platform

(2018) Wei Jiang Goh et al.   Nanoscale

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

(2018) Hosna Gomari et al.   OncoTargets and Therapy

Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression

(2018) Zhefeng Li et al.   Scientific Reports

Novel alternatives to extracellular vesicle-based immunotherapy – exosome mimetics derived from natural killer cells

(2018) Liya Zhu et al.   Artificial Cells Nanomedicine and Biotechnology

Apoptosis and apoptotic body: disease message and therapeutic target potentials

(2018) Xuebo Xu et al.   BIOSCIENCE REPORTS

Exosome-like Nanovesicles Isolated from Citrus limon L. Exert Antioxidative Effect

(2018) Nicola Baldini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Liposomal nanostructures for drug delivery in gastrointestinal cancers

(2018) Manisit Das et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Exosome as a Novel Shuttle for Delivery of Therapeutics across Biological Barriers

(2018) Chandan Kanta Das et al.   MOLECULAR PHARMACEUTICS

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Exosomes derived from human umbilical cord mesenchymal stromal cells deliver exogenous miR-145-5p to inhibit pancreatic ductal adenocarcinoma progression

(2018) Yixuan Ding et al.   CANCER LETTERS

Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

(2017) L Jiang et al.   GENE THERAPY

Exosomes From Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/β-Catenin Signaling Pathway

(2017) Xiaojun Cui et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Size-dependent cellular uptake of exosomes

(2017) Federica Caponnetto et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicle communication pathways as regulatory targets of oncogenic transformation

(2017) Dongsic Choi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

(2017) Ikuhiko Nakase et al.   Scientific Reports

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

siRNA Delivery Strategies: A Comprehensive Review of Recent Developments

(2017) Katyayani Tatiparti et al.   Nanomaterials

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis

(2017) Lingling Bai et al.   Scientific Reports

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

(2017) Wei Jiang Goh et al.   Scientific Reports

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Use of solubilizers in preclinical formulations: Effect of Cremophor EL on the pharmacokinetic properties on early discovery compounds

(2016) Bo Liu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility

(2016) Francois Bordeleau et al.   JOURNAL OF BIOMECHANICS

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Mesenchymal Stem Cells Deliver Exogenous MicroRNA-let7c via Exosomes to Attenuate Renal Fibrosis

(2016) Bo Wang et al.   MOLECULAR THERAPY

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Designed proteins induce the formation of nanocage-containing extracellular vesicles

(2016) Jörg Votteler et al.   NATURE

Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?

(2016) Tarek Magdy et al.   PHARMACOLOGY & THERAPEUTICS

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis

(2016) Ikuhiko Nakase et al.   Scientific Reports

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

(2015) Jaewoong Yoon et al.   BIOMATERIALS

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

(2014) Bodo C Melnik et al.   Journal of Translational Medicine

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

(2014) Wonju Jo et al.   LAB ON A CHIP

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles

(2014) Jingyao Mu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: Importance of zinc ions

(2014) Nadja Rebecca Brun et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Large oncosomes mediate intercellular transfer of functional microRNA

(2013) Matteo Morello et al.   CELL CYCLE

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

(2013) Songwen Ju et al.   MOLECULAR THERAPY

The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity

(2013) Joanna Baginska et al.   Frontiers in Immunology

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

(2012) Ronne Wee Yeh Yeo et al.   ADVANCED DRUG DELIVERY REVIEWS

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

siRNA-based therapeutic approaches for rheumatic diseases

(2012) Florence Apparailly et al.   Nature Reviews Rheumatology

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

(2012) Mehmet Fatih Bolukbasi et al.   Molecular Therapy-Nucleic Acids

NK cell-released exosomes

(2012) Stefano Fais   OncoImmunology

Identification of nucleotide patterns enriched in secreted RNAs as putative cis-acting elements targeting them to exosome nano-vesicles

(2011) Arsen O Batagov et al.   BMC GENOMICS

Introduction of theCIITAgene into tumor cells produces exosomes with enhanced anti-tumor effects

(2011) Yeong Shin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes

(2011) Emilio del Cacho et al.   VACCINE

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

(2010) Masako Ichihara et al.   Pharmaceutics