Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8 + T Cells

(2018) Nicolas Page et al.   IMMUNITY

Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

(2018) Giovanni Di Liberto et al.   CELL

Tissue-resident memory T cells populate the human brain

(2018) Joost Smolders et al.   Nature Communications

Protective and Pathological Immunity during Central Nervous System Infections

(2017) Robyn S. Klein et al.   IMMUNITY

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

(2016) Karin Steinbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

(2016) Christian Schläger et al.   NATURE

A scalable low-cost cGMP process for clinical grade production of the HIV inhibitor 5P12-RANTES in Pichia pastoris

(2016) Fabrice Cerini et al.   PROTEIN EXPRESSION AND PURIFICATION

Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

(2016) Nicholas Collins et al.   Nature Communications

Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells

(2015) Jasmin Herz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection

(2015) Zachary R. Shaheen et al.   JOURNAL OF IMMUNOLOGY

Oral Infection Drives a Distinct Population of Intestinal Resident Memory CD8+ T Cells with Enhanced Protective Function

(2014) Brian S. Sheridan et al.   IMMUNITY

Long-term survival of influenza virus infected club cells drives immunopathology

(2014) Nicholas S. Heaton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

(2014) Yohei Natsuaki et al.   NATURE IMMUNOLOGY

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

(2014) N. Iijima et al.   SCIENCE

Virus infection, antiviral immunity, and autoimmunity

(2013) Daniel R. Getts et al.   IMMUNOLOGICAL REVIEWS

Neuroprotective intervention by interferon-γ blockade prevents CD8+T cell–mediated dendrite and synapse loss

(2013) Mario Kreutzfeldt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs

(2013) K. Steinbach et al.   JOURNAL OF IMMUNOLOGY

Sensing and alarm function of resident memory CD8+ T cells

(2013) Jason M Schenkel et al.   NATURE IMMUNOLOGY

Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue

(2013) M. J. Gerdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

(2012) Jack van Horssen et al.   Journal of Neuroinflammation

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

Gammaherpesvirus Latency Accentuates EAE Pathogenesis: Relevance to Epstein-Barr Virus and Multiple Sclerosis

(2012) Costanza Casiraghi et al.   PLoS Pathogens

Ccr5 Regulates Inflammatory Gene Expression in Response to Encephalomyocarditis Virus Infection

(2011) Benjamin S. Christmann et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

CCL5 induces a pro-inflammatory profile in microglia in vitro

(2011) Jelena Škuljec et al.   CELLULAR IMMUNOLOGY

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

(2011) GuoQiang Sun et al.   Nature Communications

T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner

(2010) Daniel D. Pinschewer et al.   BRAIN

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

(2010) Sergio E. Baranzini et al.   NATURE

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

(2010) Qingyong Ji et al.   NATURE IMMUNOLOGY

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

(2010) L. M. Wakim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

(2009) Thomas Gebhardt et al.   NATURE IMMUNOLOGY

Analysis of CD8+ T-Cell–Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model

(2008) Juandy Jo et al.   GASTROENTEROLOGY

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide

(2008) H. Gaertner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo

(2007) Megan M. McCausland et al.   JOURNAL OF VIROLOGICAL METHODS