Novel alternatives to extracellular vesicle-based immunotherapy – exosome mimetics derived from natural killer cells

Engineering Exosomes for Cancer Therapy

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia

(2017) Prakash Gangadaran et al.   JOURNAL OF CONTROLLED RELEASE

NK Cell–derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells

(2017) Alireza Shoae-Hassani et al.   JOURNAL OF IMMUNOTHERAPY

Extracellular vesicle mimetics: Novel alternatives to extracellular vesicle-based theranostics, drug delivery, and vaccines

(2017) Oh Youn Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

(2017) Liya Zhu et al.   Theranostics

Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

(2017) Prakash Gangadaran et al.   Biomed Research International

IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities

(2017) Sigrid Dubois et al.   Cancer Immunology Research

Invariant Natural Killer T Cells in Immune Regulation of Blood Cancers: Harnessing Their Potential in Immunotherapies

(2017) Pui Yeng Lam et al.   Frontiers in Immunology

Molecular Imaging: A Useful Tool for the Development of Natural Killer Cell-Based Immunotherapies

(2017) Prakash Gangadaran et al.   Frontiers in Immunology

Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity

(2017) Congcong Zhang et al.   Frontiers in Immunology

Natural Killer Cell (NK-92MI)-Based Therapy for Pulmonary Metastasis of Anaplastic Thyroid Cancer in a Nude Mouse Model

(2017) Liya Zhu et al.   Frontiers in Immunology

Genetic engineering of human NK cells to express CXCR2 improves migration to renal cell carcinoma

(2017) Veronika Kremer et al.   Journal for ImmunoTherapy of Cancer

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

(2016) Taral R. Lunavat et al.   BIOMATERIALS

Efficient production and enhanced tumor delivery of engineered extracellular vesicles

(2016) Dionysios C. Watson et al.   BIOMATERIALS

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

Dendritic cell–derived exosomes for cancer therapy

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Human CD56brightNK Cells: An Update

(2016) Tatiana Michel et al.   JOURNAL OF IMMUNOLOGY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

In Vivo therapeutic potential of mesenchymal stem cell-derived extracellular vesicles with optical imaging reporter in tumor mice model

(2016) Senthilkumar Kalimuthu et al.   Scientific Reports

Natural Killer Cells for Immunotherapy – Advantages of the NK-92 Cell Line over Blood NK Cells

(2016) Hans Klingemann et al.   Frontiers in Immunology

In Vivo Differentiation of Therapeutic Insulin-Producing Cells from Bone Marrow Cells via Extracellular Vesicle-Mimetic Nanovesicles

(2015) Keunhee Oh et al.   ACS Nano

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

(2015) Se Jeong Lee et al.   BMC CANCER

Exosomes in development, metastasis and drug resistance of breast cancer

(2015) Dan-dan Yu et al.   CANCER SCIENCE

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma

(2015) Nadja Müller et al.   JOURNAL OF IMMUNOTHERAPY

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Potential Therapeutic Effect of Natural Killer Cells on Doxorubicin-Resistant Breast Cancer Cells In Vitro

(2015) Mi-Hye Hwang et al.   PLoS One

Cell or Cell Membrane-Based Drug Delivery Systems

(2015) Songwei Tan et al.   Theranostics

Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells

(2014) Andrea Sobo-Vujanovic et al.   CELLULAR IMMUNOLOGY

Evaluation of therapeutic effects of natural killer (NK) cell-based immunotherapy in mice using in vivo apoptosis bioimaging with a caspase-3 sensor

(2014) Ho Won Lee et al.   FASEB JOURNAL

Bacterial Protoplast-Derived Nanovesicles as Vaccine Delivery System against Bacterial Infection

(2014) Oh Youn Kim et al.   NANO LETTERS

Could bioengineered exosome-mimetic nanovesicles be an efficient strategy for the delivery of chemotherapeutics?

(2014) Su Chul Jang et al.   Nanomedicine

Functional significance of macrophage-derived exosomes in inflammation and pain

(2014) Marguerite K. McDonald et al.   PAIN

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

(2013) Mark Katakowski et al.   CANCER LETTERS

Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth

(2013) Tyler C. Moore et al.   CANCER LETTERS

Retargeting NK-92 for anti-melanoma activity by a TCR-like single-domain antibody

(2013) Ge Zhang et al.   IMMUNOLOGY AND CELL BIOLOGY

Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling

(2013) Niko P. Bretz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancement of Natural Killer Cell Cytotoxicity by Sodium/Iodide Symporter Gene-Mediated Radioiodine Pretreatment in Breast Cancer Cells

(2013) Hae Won Kim et al.   PLoS One

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

NK cell-released exosomes

(2012) Stefano Fais   OncoImmunology

Exosome nanotechnology: An emerging paradigm shift in drug delivery

(2011) Samira Lakhal et al.   BIOESSAYS

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Cell vehicle targeting strategies

(2008) J C Roth et al.   GENE THERAPY

Impact of Cytokine- and FasL-induced Apoptosis in the β-Cell Line NIT-1

(2008) P. Augstein et al.   HORMONE AND METABOLIC RESEARCH

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY