Targeting TANK-binding kinase 1 (TBK1) in cancer

Autophagy and disease: unanswered questions

(2020) Ying Yang et al.   CELL DEATH AND DIFFERENTIATION

Combining microenvironment normalization strategies to improve cancer immunotherapy

(2020) Fotios Mpekris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)

(2020) Xin Xu et al.   Cell Death & Disease

TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability

(2020) Ziad Bakouny et al.   Cancer Discovery

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

(2020) Katherine R. Balka et al.   Cell Reports

Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response

(2020) Zhihua Ren et al.   Frontiers in Immunology

Type 1 interferons as a potential treatment against COVID-19

(2020) Erwan Sallard et al.   ANTIVIRAL RESEARCH

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Organoid Models of Tumor Immunology

(2020) Kanako Yuki et al.   TRENDS IN IMMUNOLOGY

Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes

(2019) Chong Shin et al.   Cells

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

(2019) Douglas W. Thomson et al.   ACS Medicinal Chemistry Letters

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

(2019) Yanyu Zhang et al.   FASEB JOURNAL

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation

(2019) Suresh Kumar et al.   DEVELOPMENTAL CELL

Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

(2019) Nina Germic et al.   CELL DEATH AND DIFFERENTIATION

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

(2019) Yunhao Tan et al.   CELL

Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer

(2019) Ryan T. Bishop et al.   CANCER LETTERS

TANK-binding kinase 1 as a novel therapeutic target for viral diseases

(2019) Chunyuan Zhao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

(2019) Baoyu Zhao et al.   NATURE

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

RNF144B inhibits LPS‐induced inflammatory responses via binding TBK1

(2019) Zhen Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The E3 ubiquitin ligase TBK1 mediates the degradation of multiple picornavirus VP3 proteins by phosphorylation and ubiquitination

(2019) Dan Li et al.   JOURNAL OF VIROLOGY

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Adaptive mutability of colorectal cancers in response to targeted therapies

(2019) Mariangela Russo et al.   SCIENCE

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877

(2019) Ricardo J. Antonia et al.   Scientific Reports

PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

(2019) Shireen A. Sarraf et al.   Cell Reports

Advances in IKBKE as a potential target for cancer therapy

(2019) Min Yin et al.   Cancer Medicine

IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway

(2019) Hongning Cai et al.   BIOMEDICINE & PHARMACOTHERAPY

TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis

(2019) Lele Zhu et al.   NATURE CELL BIOLOGY

TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss

(2019) Lianxin Hu et al.   Cancer Discovery

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Phosphatase Cdc25A negatively regulates antiviral immune response by inhibiting TBK1 activity

(2018) Dandan Qi et al.   JOURNAL OF VIROLOGY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing

(2018) Deng Pan et al.   SCIENCE

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye

(2018) Dinesh Jaishankar et al.   Science Translational Medicine

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS -Mutant Lung Adenocarcinoma

(2018) Ferdinandos Skoulidis et al.   Cancer Discovery

Therapeutic effects of a TBK1 kinase inhibitor in germinal center-driven, autoantibody-mediated inflammatory arthritis

(2018) Cynthia Louis et al.   Arthritis & Rheumatology

TANK-Binding Kinase 1-Dependent Responses in Health and Autoimmunity

(2018) Cynthia Louis et al.   Frontiers in Immunology

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation

(2018) Yi Wei Hu et al.   Frontiers in Immunology

Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction

(2018) Victoria H. Cruz et al.   Molecular Metabolism

Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity

(2018) Tyler S. Beyett et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

(2018) Shunsuke Kitajima et al.   CANCER CELL

Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1

(2018) Haiyang Yu et al.   CELL

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog - Mutated Non–Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure

(2018) David A. Barbie et al.   Clinical Lung Cancer

Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma

(2018) Kimmie Ng et al.   INVESTIGATIONAL NEW DRUGS

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF-κB signaling

(2018) Chaping Cheng et al.   Theranostics

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

(2018) Joel Durand et al.   Cells

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

TBK1 and IKKε restrain cell death

(2018) Klaus Heger et al.   NATURE CELL BIOLOGY

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

(2018) J.-M. Heo et al.   Science Advances

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

(2017) Yichuan Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

(2017) Andrew P. Crew et al.   JOURNAL OF MEDICINAL CHEMISTRY

JAK1/2 Inhibitors AZD1480 and CYT387 Inhibit Canine B-Cell Lymphoma Growth by Increasing Apoptosis and Disrupting Cell Proliferation

(2017) Z. Lu et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

(2017) Mohammad Fallahi‐Sichani et al.   Molecular Systems Biology

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

(2017) Qian Zhang et al.   NATURE CELL BIOLOGY

Functional precision cancer medicine—moving beyond pure genomics

(2017) Anthony Letai   NATURE MEDICINE

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

(2017) Maroof Hasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines

(2017) Yang Liu et al.   Cell Death & Disease

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

(2017) Banu Eskiocak et al.   Cancer Discovery

Refining Targeted Therapy Opportunities for BRAF -Mutant Melanoma

(2017) Russell W. Jenkins et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling

(2017) Wei Chen et al.   Journal of Cancer

The Glycolytic Switch in Tumors: How Many Players Are Involved?

(2017) Li Yu et al.   Journal of Cancer

Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

(2017) Victoria H. Cruz et al.   Journal of Cell Communication and Signaling

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

(2016) Marie Pourcelot et al.   BMC BIOLOGY

Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway

(2016) Robert Weil et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Cellular Innate Immunity: An Old Game with New Players

(2016) Georg Gasteiger et al.   Journal of Innate Immunity

E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1

(2016) Guanhua Song et al.   NATURE IMMUNOLOGY

Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies

(2016) Maroof Hasan et al.   PHARMACOLOGICAL RESEARCH

Amlexanox Blocks the Interaction between S100A4 and Epidermal Growth Factor and Inhibits Cell Proliferation

(2016) Ching Chang Cho et al.   PLoS One

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

(2016) Andrew S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

(2016) Nieves Peltzer et al.   TRENDS IN CELL BIOLOGY

Human TBK1: A Gatekeeper of Neuroinflammation

(2016) Liyana Ahmad et al.   TRENDS IN MOLECULAR MEDICINE

Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells

(2016) Tong Zhou et al.   Oncotarget

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

(2016) Marco Onorati et al.   Cell Reports

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

(2016) S. Yang et al.   Cancer Immunology Research

SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity

(2015) Vera V. Saul et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27

(2015) Qingliang Zheng et al.   CELL RESEARCH

BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest

(2015) Li-Yuan Bai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

(2015) Gen Matsumoto et al.   HUMAN MOLECULAR GENETICS

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1

(2015) Zhenzhen Zhan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice

(2015) Maroof Hasan et al.   JOURNAL OF IMMUNOLOGY

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis

(2015) Smitha Pillai et al.   Nature Communications

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation

(2015) Jiayi Yu et al.   Nature Communications

Database of Genomic Biomarkers for Cancer Drugs and Clinical Targetability in Solid Tumors

(2015) Rodrigo Dienstmann et al.   Cancer Discovery

PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

(2015) Zexing Li et al.   PLoS Pathogens

TBK1 Regulates Prostate Cancer Dormancy through mTOR Inhibition

(2015) Jin Koo Kim et al.   NEOPLASIA

shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer

(2014) T. Deng et al.   CANCER RESEARCH

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

(2014) Thanh U. Barbie et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin-Specific Protease 2b Negatively Regulates IFN-β Production and Antiviral Activity by Targeting TANK-Binding Kinase 1

(2014) Lei Zhang et al.   JOURNAL OF IMMUNOLOGY

Inhibition of TBK1 attenuates radiation-induced epithelial–mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1

(2014) Wen Liu et al.   LABORATORY INVESTIGATION

Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma

(2014) Ha Linh Vu et al.   MOLECULAR CANCER RESEARCH

Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer

(2014) Congwen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit

(2014) Z. Zhu et al.   Cancer Discovery

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Loss of TBK1 Induces Epithelial-Mesenchymal Transition in the Breast Cancer Cells by ER  Downregulation

(2013) K.-M. Yang et al.   CANCER RESEARCH

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

(2013) Elizabeth Helgason et al.   FEBS LETTERS

Negative regulation of TBK1-mediated antiviral immunity

(2013) Wei Zhao   FEBS LETTERS

Safety and efficacy of CYT387, a JAK1 and JAK2 inhibitor, in myelofibrosis

(2013) A Pardanani et al.   LEUKEMIA

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells

(2013) J.-Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

(2013) Chang Shu et al.   STRUCTURE

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

(2013) Daqi Tu et al.   Cell Reports

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

(2013) Amede Larabi et al.   Cell Reports

PPM1B negatively regulates antiviral response via dephosphorylating TBK1

(2012) Yanling Zhao et al.   CELLULAR SIGNALLING

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HeterozygousTBK1mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

(2012) Melina Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages

(2012) Tao Yu et al.   MEDIATORS OF INFLAMMATION

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

TBK1 Kinase Addiction in Lung Cancer Cells Is Mediated via Autophagy of Tax1bp1/Ndp52 and Non-Canonical NF-κB Signalling

(2012) Alice C. Newman et al.   PLoS One

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Autophagy and Neuronal Cell Death in Neurological Disorders

(2012) R. A. Nixon et al.   Cold Spring Harbor Perspectives in Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

(2011) Shitao Li et al.   IMMUNITY

The C-Terminal 42 Residues of the Tula Virus Gn Protein Regulate Interferon Induction

(2011) V. Matthys et al.   JOURNAL OF VIROLOGY

The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase

(2011) D. Wang et al.   JOURNAL OF VIROLOGY

TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

(2011) Yi-Hung Ou et al.   MOLECULAR CELL

Functional Dissection of the TBK1 Molecular Network

(2011) Adriana Goncalves et al.   PLoS One

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy

(2011) H. Weidberg et al.   Science Signaling

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

(2011) Leonie Unterholzner et al.   PLoS Pathogens

TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases

(2010) Kislay Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

(2009) Kam-Leung Siu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance

(2009) Marina C Muñoz et al.   JOURNAL OF ENDOCRINOLOGY

CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients

(2009) A Pardanani et al.   LEUKEMIA

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

(2009) Chen Wang et al.   NATURE IMMUNOLOGY

ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

(2008) Dahai Zheng et al.   CELL RESEARCH

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

(2008) Martina Schröder et al.   EMBO JOURNAL

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

(2008) Constantin S Friedman et al.   EMBO REPORTS

Influence of TBK-1 on tumor angiogenesis and microvascular inflammation

(2008) Marcus Czabanka   Frontiers in Bioscience-Landmark

Negative Regulation of Virus-triggered IFN-β Signaling Pathway by Alternative Splicing of TBK1

(2008) Weiwen Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of TANK-binding Kinase 1-mediated Signaling by the γ134.5 Protein of Herpes Simplex Virus 1

(2008) Dustin Verpooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY