Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

SCN 1A /Na V 1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models

(2020) Massimo Mantegazza et al.   EPILEPSIA

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?

(2020) Wolfgang Löscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of action of currently used antiseizure drugs

(2020) Graeme J. Sills et al.   NEUROPHARMACOLOGY

The feast and famine: Epilepsy treatment and treatment gaps in early 21st century

(2020) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

From next generation sequencing to targeted treatment of non-acquired epilepsies

(2019) Rikke S Møller et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy

(2019) Marian Galovic et al.   JAMA Neurology

Functional deficiency in endogenous interleukin-1 receptor antagonist in patients with febrile infection-related epilepsy syndrome

(2019) Benjamin D. S. Clarkson et al.   ANNALS OF NEUROLOGY

MicroRNA-146a-5p Downregulates the Expression of P-Glycoprotein in Rats with Lithium–Pilocarpine-Induced Status Epilepticus

(2019) Xiaolin Deng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient

(2019) Philippe Ryvlin et al.   CURRENT OPINION IN NEUROLOGY

A pericyte‐glia scarring develops at the leaky capillaries in the hippocampus during seizure activity

(2019) Wendy Klement et al.   EPILEPSIA

Microbiota-gut brain axis involvement in neuropsychiatric disorders

(2019) Luigi Francesco Iannone et al.   Expert Review of Neurotherapeutics

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

Targeting microRNA-134 for seizure control and disease modification in epilepsy

(2019) Gareth Morris et al.   EBioMedicine

Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

(2019) Yen-Chen Anne Feng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel therapies for epilepsy in the pipeline

(2019) Boulenouar Mesraoua et al.   EPILEPSY & BEHAVIOR

Centromedian thalamic nuclei deep brain stimulation and Anakinra treatment for FIRES – Two different outcomes

(2019) Mario Sa et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Epilepsy genetics and the precision medicine matrix

(2019) Sanjay M Sisodiya   LANCET NEUROLOGY

Emerging roles for the intestinal microbiome in epilepsy

(2019) Gregory R. Lum et al.   NEUROBIOLOGY OF DISEASE

Blood–brain barrier dysfunction in status epileptics: Mechanisms and role in epileptogenesis

(2019) Evyatar Swissa et al.   EPILEPSY & BEHAVIOR

Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models

(2019) Karine Leclercq et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Interactions with Synaptic Vesicle 2 Proteins and the GABAA Receptor

(2019) Martyn Wood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Current Approach of the Epilepsy Therapy Screening Program Contract Site for Identifying Improved Therapies for the Treatment of Pharmacoresistant Seizures in Epilepsy.

(2019) Karen S. Wilcox et al.   NEUROPHARMACOLOGY

Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy

(2019) Eric R. Wengert et al.   NEUROPHARMACOLOGY

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

(2019) Gregory L Krauss et al.   LANCET NEUROLOGY

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives

(2018) Antonio Gambardella et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammation and Epilepsy: Preclinical Findings and Potential Clinical Translation

(2018) Gaetano Terrone et al.   CURRENT PHARMACEUTICAL DESIGN

Lamotrigine-resistant corneal-kindled mice: A model of pharmacoresistant partial epilepsy for moderate-throughput drug discovery

(2018) Zachery Koneval et al.   EPILEPSIA

The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue

(2018) Lora D. Weidner et al.   EPILEPSIA

Clinical reappraisal of the influence of drug-transporter polymorphisms in epilepsy

(2018) Azzurra Orlandi et al.   Expert Opinion on Drug Metabolism & Toxicology

Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade

(2018) Allen D. DeSena et al.   Journal of Neuroinflammation

Neuroinflammation Alters Integrative Properties of Rat Hippocampal Pyramidal Cells

(2018) Federica Frigerio et al.   MOLECULAR NEUROBIOLOGY

Risk for injuries and accidents in epilepsy

(2018) Benno Mahler et al.   NEUROLOGY

Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies

(2018) E. A. van Vliet et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pharmacogenomics in epilepsy

(2018) Simona Balestrini et al.   NEUROSCIENCE LETTERS

Epigenetics in epilepsy

(2018) K. Kobow et al.   NEUROSCIENCE LETTERS

Reproducibility of preclinical animal research improves with heterogeneity of study samples

(2018) Bernhard Voelkl et al.   PLOS BIOLOGY

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

Preclinical Animal Models for Dravet Syndrome: Seizure Phenotypes, Comorbidities and Drug Screening

(2018) Aliesha Griffin et al.   Frontiers in Pharmacology

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

Overall and cause-specific premature mortality in epilepsy: A systematic review

(2018) Musa M. Watila et al.   EPILEPSY & BEHAVIOR

Individualized treatment approaches: Fenfluramine, a novel antiepileptic medication for the treatment of seizures in Dravet syndrome

(2018) Tilman Polster   EPILEPSY & BEHAVIOR

Altered composition of the gut microbiome in patients with drug-resistant epilepsy

(2018) Anjiao Peng et al.   EPILEPSY RESEARCH

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

(2018) Kay L. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target

(2018) Prashant K. Srivastava et al.   Nature Communications

Current Treatment Strategies and Future Treatment Options for Dravet Syndrome

(2018) Julie Ziobro et al.   Current Treatment Options in Neurology

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development

(2018) Meir Bialer et al.   EPILEPSIA

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs

(2018) Peter J. West et al.   EPILEPSIA

The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis

(2018) Linda Kalilani et al.   EPILEPSIA

Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?

(2018) Gaetano Zaccara et al.   EPILEPSIA

Emerging drugs for the treatment of Dravet syndrome

(2018) Francesco Brigo et al.   EXPERT OPINION ON EMERGING DRUGS

From molecules to medicines: the dawn of targeted therapies for genetic epilepsies

(2018) Scott T. Demarest et al.   Nature Reviews Neurology

Clinical studies and anti-inflammatory mechanisms of treatments

(2017) Jacqueline A. French et al.   EPILEPSIA

Neuroinflammation imaging markers for epileptogenesis

(2017) Matthias J. Koepp et al.   EPILEPSIA

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures

(2017) Cameron S. Metcalf et al.   EPILEPSIA

A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo

(2017) Kristen Frederiksen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy

(2017) Anika M. S. Hartz et al.   MOLECULAR PHARMACEUTICS

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond

(2017) Roger J. Porter et al.   NEUROCHEMICAL RESEARCH

Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs

(2017) Wolfgang Löscher   NEUROCHEMICAL RESEARCH

The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)

(2017) John H. Kehne et al.   NEUROCHEMICAL RESEARCH

Epilepsy-associated genes

(2017) Jie Wang et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Drug development for refractory epilepsy: The past 25 years and beyond

(2017) Ambica Golyala et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults

(2017) Soo Young Kim et al.   Scientific Reports

Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers

(2017) Fei Tang et al.   Frontiers in Neurology

miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model

(2016) Sierk Haenisch et al.   ACS Chemical Neuroscience

Febrile infection-related epilepsy syndrome treated with anakinra

(2016) Daniel L. Kenney-Jung et al.   ANNALS OF NEUROLOGY

Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment

(2016) Jerome Niquet et al.   Annals of the New York Academy of Sciences

Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy

(2016) Venceslas Duveau et al.   CNS Neuroscience & Therapeutics

Pharmacological Treatment of Drug-Resistant Epilepsy in Adults: a Practical Guide

(2016) Martin J. Brodie   Current Neurology and Neuroscience Reports

Low dose verapamil as an adjunct therapy for medically refractory epilepsy – An open label pilot study

(2016) Jaishree Narayanan et al.   EPILEPSY RESEARCH

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

ABC transporters at the blood–brain barrier

(2016) Anne Mahringer et al.   Expert Opinion on Drug Metabolism & Toxicology

Comorbidities of epilepsy: current concepts and future perspectives

(2016) Mark R Keezer et al.   LANCET NEUROLOGY

The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?

(2016) Wolfgang Löscher   NEUROCHEMICAL RESEARCH

Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice

(2016) Zheng-Hao Xu et al.   NEUROSCIENCE

ABCB1 genotyping in the treatment of depression

(2016) Tanja Maria Brückl et al.   PHARMACOGENOMICS

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet

(2016) Michael A. Rogawski et al.   Cold Spring Harbor Perspectives in Medicine

Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome

(2016) J. Hsiao et al.   EBioMedicine

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals

(2015) Mette Berendt et al.   BMC Veterinary Research

Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies

(2015) Xixi Du et al.   Current Neurology and Neuroscience Reports

Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model

(2015) Karine Leclercq et al.   EPILEPSY & BEHAVIOR

Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish

(2015) Karine Leclercq et al.   EPILEPSY & BEHAVIOR

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial

(2015) Ronit M Pressler et al.   LANCET NEUROLOGY

Reprogramming patient-derived cells to study the epilepsies

(2015) Jack M Parent et al.   NATURE NEUROSCIENCE

Animal models in epilepsy research: legacies and new directions

(2015) Brian P Grone et al.   NATURE NEUROSCIENCE

Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies

(2015) Aristea S. Galanopoulou et al.   NEUROBIOLOGY OF DISEASE

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

GABA A currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

(2015) Cristina Roseti et al.   NEUROBIOLOGY OF DISEASE

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

(2015) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice

(2015) Sabine Klein et al.   NEUROPHARMACOLOGY

The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2)

(2015) Kerstin Römermann et al.   NEUROPHARMACOLOGY

Blood–brain barrier dysfunction, seizures and epilepsy

(2015) E.A. van Vliet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Malformations of Cortical Development and Epilepsy

(2015) A. J. Barkovich et al.   Cold Spring Harbor Perspectives in Medicine

Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

(2015) Suzanne F.C. Miller-Delaney et al.   BRAIN

Losartan prevents acquired epilepsy via TGF-β signaling suppression

(2014) Guy Bar-Klein et al.   ANNALS OF NEUROLOGY

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

(2014) Anna Doeser et al.   BRAIN

Models in Research of Pharmacoresistant Epilepsy: Present and Future in Development of Antiepileptic Drugs

(2014) R. Kovacs et al.   CURRENT MEDICINAL CHEMISTRY

Neuroimaging of drug resistance in epilepsy

(2014) Matthias J. Koepp   CURRENT OPINION IN NEUROLOGY

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures

(2014) Martin Puskarjov et al.   EPILEPSIA

Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures

(2014) Seda Salar et al.   EPILEPSIA

A pilot double-blind trial using verapamil as adjuvant therapy for refractory seizures

(2014) Felippe Borlot et al.   EPILEPSY RESEARCH

Antiepileptic efficacy of lamotrigine in phenobarbital-resistant and -responsive epileptic rats: A pilot study

(2014) Claudia Brandt et al.   EPILEPSY RESEARCH

Low potency and limited efficacy of antiepileptic drugs in the mouse 6Hz corneal kindling model

(2014) K. Leclercq et al.   EPILEPSY RESEARCH

Association of MDR1 gene C3435T polymorphism with childhood intractable epilepsy: a meta-analysis

(2014) Guilian Sun et al.   JOURNAL OF NEURAL TRANSMISSION

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

(2014) Asheebo Rojas et al.   NEUROBIOLOGY OF DISEASE

In vivo P-glycoprotein function before and after epilepsy surgery

(2014) M. Bauer et al.   NEUROLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

The Pharmacology of Imepitoin: The First Partial Benzodiazepine Receptor Agonist Developed for the Treatment of Epilepsy

(2013) Chris Rundfeldt et al.   CNS DRUGS

The methylation hypothesis of pharmacoresistance in epilepsy

(2013) Katja Kobow et al.   EPILEPSIA

Animal and human data: Where are our concepts for drug-resistant epilepsy going?

(2013) Heidrun Potschka   EPILEPSIA

Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: A novel experimental model of pharmacoresistant epilepsy

(2013) Ajay K. Srivastava et al.   EPILEPSIA

The intrinsic severity hypothesis of pharmacoresistance to antiepileptic drugs

(2013) Michael A. Rogawski   EPILEPSIA

Canine epilepsy as a translational model?

(2013) Heidrun Potschka et al.   EPILEPSIA

Fractalkine/CX3CL1 modulates GABAAcurrents in human temporal lobe epilepsy

(2013) Cristina Roseti et al.   EPILEPSIA

Adjunctive use of verapamil in patients with refractory temporal lobe epilepsy: A pilot study

(2013) Ali A. Asadi-Pooya et al.   EPILEPSY & BEHAVIOR

Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model

(2013) Marion Bankstahl et al.   EPILEPSY RESEARCH

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

(2013) Maria Feldmann et al.   LANCET NEUROLOGY

Dynamic Regulation of P-glycoprotein in Human Brain Capillaries

(2013) Janine Avemary et al.   MOLECULAR PHARMACEUTICS

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage

(2012) Laura Librizzi et al.   ANNALS OF NEUROLOGY

Neuropathology of the blood–brain barrier and pharmaco-resistance in human epilepsy

(2012) Joan Y. W. Liu et al.   BRAIN

Do ATP-Binding Cassette Transporters Cause Pharmacoresistance in Epilepsy? Problems and Approaches in Determining which Antiepileptic Drugs are Affected

(2012) Wolfgang Loscher et al.   CURRENT PHARMACEUTICAL DESIGN

Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology

(2012) Federica Frigerio et al.   EPILEPSIA

How theories evolved concerning the mechanism of action of barbiturates

(2012) Wolfgang Löscher et al.   EPILEPSIA

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

Pharmacoresistance and the role of surgery in difficult to treat epilepsy

(2012) Samuel Wiebe et al.   Nature Reviews Neurology

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders

(2012) Yehezkel Ben-Ari et al.   NEUROSCIENTIST

The transport of antiepileptic drugs by P-glycoprotein

(2011) Chunbo Zhang et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport

(2011) Heidrun Potschka   ADVANCED DRUG DELIVERY REVIEWS

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

(2011) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings

(2011) Fionn E O'Brien et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological Diseases

(2011) Chaitali Ghosh et al.   CURRENT DRUG METABOLISM

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy

(2011) Marion Bankstahl et al.   EXPERIMENTAL NEUROLOGY

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

The Anticonvulsant Response to Valproate in Kindled Rats Is Correlated with Its Effect on Neuronal Firing in the Substantia Nigra Pars Reticulata: A New Mechanism of Pharmacoresistance

(2011) K. Tollner et al.   JOURNAL OF NEUROSCIENCE

Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

(2011) M. Morin-Brureau et al.   JOURNAL OF NEUROSCIENCE

A new hypothesis of drug refractory epilepsy: Neural network hypothesis

(2011) Min Fang et al.   MEDICAL HYPOTHESES

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association ofABCB1gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis

(2011) Batoul Sadat Haerian et al.   PHARMACOGENOMICS

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy

(2010) J Schlichtiger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulating P-glycoprotein regulation: Future perspectives for pharmacoresistant epilepsies?

(2010) Heidrun Potschka   EPILEPSIA

In search of models of pharmacoresistant epilepsy

(2010) Abdul Wahab et al.   EPILEPSIA

Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models

(2010) Nicole M. Rowley et al.   EPILEPSY RESEARCH

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

(2010) Linda Holtman et al.   EPILEPSY RESEARCH

Antiepileptic and Antiepileptogenic Performance of Carisbamate after Head Injury in the Rat: Blind and Randomized Studies

(2010) C. L. Eastman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Early seizure frequency and aetiology predict long-term medical outcome in childhood-onset epilepsy

(2009) M. Sillanpaa et al.   BRAIN

The NINDS Epilepsy Research Benchmarks

(2009) Melinda S. Kelley et al.   EPILEPSIA

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy

(2009) Wolfgang Löscher et al.   EPILEPSIA

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

(2009) L. Holtman et al.   EPILEPSY RESEARCH

Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation

(2009) A. Pekcec et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Age-dependent vascular changes induced by status epilepticus in rat forebrain: Implications for epileptogenesis

(2009) Jessica Marcon et al.   NEUROBIOLOGY OF DISEASE

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

(2009) Guido Zibell et al.   NEUROPHARMACOLOGY

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

New Developments in Antiepileptic Drug Resistance: An Integrative View

(2009) Dieter Schmidt et al.   Epilepsy Currents

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1 

(2008) S. Balosso et al.   BRAIN

Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models

(2008) Miriam Marcela Blanco et al.   EPILEPSIA

Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam

(2008) Rafal M. Kaminski et al.   EPILEPSIA

The clinical impact of pharmacogenetics on the treatment of epilepsy

(2008) Wolfgang Löscher et al.   EPILEPSIA

Mechanisms of drug resistance in epilepsy: relevance for antiepileptic drug discovery

(2008) Doru Georg Margineanu et al.   Expert Opinion on Drug Discovery

Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy

(2008) Kerstin Bethmann et al.   NEUROBIOLOGY OF DISEASE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

Antagonism of peripheral inflammation reduces the severity of status epilepticus

(2008) Nicola Marchi et al.   NEUROBIOLOGY OF DISEASE

Intrinsic Severity as a Determinant of Antiepileptic Drug Refractoriness

(2008) Michael A. Rogawski et al.   Epilepsy Currents

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY