Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs

Various modifications of the intrahippocampal kainate model of mesial temporal lobe epilepsy in rats fail to resolve the marked rat-to-mouse differences in type and frequency of spontaneous seizures in this model

(2017) Rebecca Klee et al.   EPILEPSY & BEHAVIOR

The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond

(2017) Roger J. Porter et al.   NEUROCHEMICAL RESEARCH

The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)

(2017) John H. Kehne et al.   NEUROCHEMICAL RESEARCH

Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy

(2017) Melissa L. Barker-Haliski et al.   NEUROCHEMICAL RESEARCH

Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy

(2016) Venceslas Duveau et al.   CNS Neuroscience & Therapeutics

The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice

(2016) Thomas Erker et al.   EPILEPSIA

Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy

(2016) Melissa L. Barker-Haliski et al.   EPILEPSIA

Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures

(2016) Kathrin Töllner et al.   EPILEPSY & BEHAVIOR

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies

(2016) Antoine Depaulis et al.   JOURNAL OF NEUROSCIENCE METHODS

Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration

(2016) Maxime Lévesque et al.   JOURNAL OF NEUROSCIENCE METHODS

The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?

(2016) Wolfgang Löscher   NEUROCHEMICAL RESEARCH

Infections, inflammation and epilepsy

(2015) Annamaria Vezzani et al.   ACTA NEUROPATHOLOGICA

Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model

(2015) Karine Leclercq et al.   EPILEPSY & BEHAVIOR

Animal models in epilepsy research: legacies and new directions

(2015) Brian P Grone et al.   NATURE NEUROSCIENCE

Pathogenesis and new candidate treatments for infantile spasms and early life epileptic encephalopathies: A view from preclinical studies

(2015) Aristea S. Galanopoulou et al.   NEUROBIOLOGY OF DISEASE

Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice

(2015) Sabine Klein et al.   NEUROPHARMACOLOGY

Treatment-resistant depression: are animal models of depression fit for purpose?

(2015) Paul Willner et al.   PSYCHOPHARMACOLOGY

Progress and Outlooks in a Genetic Absence Epilepsy Model (WAG/Rij)

(2014) G. Luijtelaar et al.   CURRENT MEDICINAL CHEMISTRY

Low potency and limited efficacy of antiepileptic drugs in the mouse 6Hz corneal kindling model

(2014) K. Leclercq et al.   EPILEPSY RESEARCH

A novel open-source drug-delivery system that allows for first-of-kind simulation of nonadherence to pharmacological interventions in animal disease models

(2014) Kyle E. Thomson et al.   JOURNAL OF NEUROSCIENCE METHODS

The challenge and promise of anti-epileptic therapy development in animal models

(2014) Michele Simonato et al.   LANCET NEUROLOGY

Searching for the Ideal Antiepileptogenic Agent in Experimental Models: Single Treatment Versus Combinatorial Treatment Strategies

(2014) H. Steve White et al.   Neurotherapeutics

Genetic Epilepsy Syndromes Without Structural Brain Abnormalities: Clinical Features and Experimental Models

(2014) Renzo Guerrini et al.   Neurotherapeutics

Fit-for purpose use of mouse models to improve predictivity of cancer therapeutics evaluation

(2014) K. Wartha et al.   PHARMACOLOGY & THERAPEUTICS

Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy

(2013) Gabi Dezsi et al.   EPILEPSIA

Proposal for a “phase II” multicenter trial model for preclinical new antiepilepsy therapy development

(2013) Terence J. O'Brien et al.   EPILEPSIA

Development of new treatment approaches for epilepsy: Unmet needs and opportunities

(2013) Jacqueline A. French et al.   EPILEPSIA

Issues related to development of new antiseizure treatments

(2013) Karen S. Wilcox et al.   EPILEPSIA

Pilocarpine-induced epilepsy in mice alters seizure thresholds and the efficacy of antiepileptic drugs in the 6-Hertz psychomotor seizure model

(2013) Marion Bankstahl et al.   EPILEPSY RESEARCH

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

(2013) Maria Feldmann et al.   LANCET NEUROLOGY

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Seizing the moment for the future: The U.S. Anticonvulsant Screening Project

(2012) Wolfgang Löscher et al.   EPILEPSIA

How theories evolved concerning the mechanism of action of barbiturates

(2012) Wolfgang Löscher et al.   EPILEPSIA

Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats

(2012) Ajay K. Srivastava et al.   EPILEPSY RESEARCH

Novel Animal Models of Pediatric Epilepsy

(2012) Stéphane Auvin et al.   Neurotherapeutics

Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model

(2011) Emilio Russo et al.   EPILEPSIA

A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models

(2011) Atif Ali et al.   EPILEPSIA

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy

(2011) Marion Bankstahl et al.   EXPERIMENTAL NEUROLOGY

Neurotropic viral infections leading to epilepsy: focus on Theiler’s murine encephalomyelitis virus

(2011) Jane E Libbey et al.   Future Virology

Anti-epileptogenesis in rodent post-traumatic epilepsy models

(2011) Asla Pitkänen et al.   NEUROSCIENCE LETTERS

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Hallmarks in 18th- and 19th-century epilepsy research

(2010) K. Sidiropoulou et al.   EPILEPSY & BEHAVIOR

Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models

(2010) Nicole M. Rowley et al.   EPILEPSY RESEARCH

ECoG studies of valproate, carbamazepine and halothane in frontal-lobe epilepsy induced by head injury in the rat

(2010) Clifford L. Eastman et al.   EXPERIMENTAL NEUROLOGY

Development of Postinfection Epilepsy After Theiler's Virus Infection of C57BL/6 Mice

(2010) Kerry-Ann A. Stewart et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Antiepileptic and Antiepileptogenic Performance of Carisbamate after Head Injury in the Rat: Blind and Randomized Studies

(2010) C. L. Eastman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Antiepileptic drug therapy the story so far

(2010) Martin J. Brodie   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Drug treatment of epilepsy in the century of the ILAE: The first 50 years, 1909-1958

(2009) Simon D. Shorvon   EPILEPSIA

Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy

(2009) Emilio Russo et al.   EPILEPSIA

Drug treatment of epilepsy in the century of the ILAE: The second 50 years, 1959-2009

(2009) Simon D. Shorvon   EPILEPSIA

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Book Review The Legacy of Tracy J. Putnam and H. Houston Merritt: Modern Neurology in the United States By Lewis P. Rowland. 159 pp., illustrated. New York, Oxford University Press, 2009. $24.95. 978-0-19-537952-5

(2009) Henry J. Kaminski   NEW ENGLAND JOURNAL OF MEDICINE

A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy

(2008) Heidi L. Grabenstatter et al.   EPILEPSIA

Early treatment suppresses the development of spike-wave epilepsy in a rat model

(2008) Hal Blumenfeld et al.   EPILEPSIA

Assessment of seizure susceptibility in pilocarpine epileptic and nonepileptic Wistar rats and of seizure reinduction with pentylenetetrazole and electroshock models

(2008) Miriam Marcela Blanco et al.   EPILEPSIA

The pilocarpine model of temporal lobe epilepsy

(2008) Giulia Curia et al.   JOURNAL OF NEUROSCIENCE METHODS