Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks

DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation

(2016) Emil Mladenov et al.   SEMINARS IN CANCER BIOLOGY

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation

(2016) Ameer L. Elaimy et al.   Oncotarget

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

(2015) Kirsten Lauber et al.   CANCER LETTERS

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

(2015) Benjamin A. Hilton et al.   MOLECULAR CELL

Clathrin Heavy Chain Interacts With Estrogen Receptor α and Modulates 17β-Estradiol Signaling

(2015) Pierangela Totta et al.   MOLECULAR ENDOCRINOLOGY

ATM kinase sustains HER2 tumorigenicity in breast cancer

(2015) Venturina Stagni et al.   Nature Communications

SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG

(2014) Shaoxiang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of the Interactors of Human Nibrin (NBN) and of Its 26 kDa and 70 kDa Fragments Arising from the NBN 657del5 Founder Mutation

(2014) Domenica Cilli et al.   PLoS One

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Heat Shock Protein 90 (Hsp90) Selectively Regulates the Stability of KDM4B/JMJD2B Histone Demethylase

(2013) Inbal Ipenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Double strand break repair functions of histone H2AX

(2013) Ralph Scully et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability

(2012) Min Hwa Shin et al.   CELL CYCLE

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation

(2012) Gina Mendez et al.   IUBMB LIFE

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RING Finger Protein RNF8 Ubiquitinates Nbs1 to Promote DNA Double-strand Break Repair by Homologous Recombination

(2012) Chi-Sheng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

(2012) Stephanie Jungmichel et al.   NUCLEIC ACIDS RESEARCH

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

(2012) Naihan Xu et al.   Journal of Oncology

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of Hsp90 in protein complex assembly

(2011) Taras Makhnevych et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

(2011) Magtouf Gatei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

(2011) Kirti Sharma et al.   MOLECULAR & CELLULAR PROTEOMICS

Hsp90 Inhibitor-Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage

(2011) K. Ha et al.   MOLECULAR CANCER THERAPEUTICS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

(2009) Michela Di Virgilio et al.   DNA REPAIR

DNA-PKcs and ATM co-regulate DNA double-strand break repair

(2009) Meena Shrivastav et al.   DNA REPAIR

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NBS1 Prevents Chromatid-Type Aberrations through ATM-Dependent Interactions with SMC1

(2008) A. Antoccia et al.   RADIATION RESEARCH