Unlocking P(V): Reagents for chiral phosphorothioate synthesis

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

(2017) Naoki Iwamoto et al.   NATURE BIOTECHNOLOGY

Electronic Structures of LNA Phosphorothioate Oligonucleotides

(2017) Henrik G. Bohr et al.   Molecular Therapy-Nucleic Acids

Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine–Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING)

(2016) Thierry Lioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Practical and Reliable Synthesis of 1,2-Dideoxy-d-ribofuranose and its Application in RNAi Studies

(2016) Yuki Nagaya et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Current complexity: a tool for assessing the complexity of organic molecules

(2015) Jun Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides

(2014) Na Fei et al.   CHEMICAL COMMUNICATIONS

(3′-5′)-Cyclic Dinucleotides: Synthetic Strategies and Biological Potential

(2013) Pascale Clivio et al.   CHEMICAL REVIEWS

Stereocontrolled Solid-Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2′-O-(2-Cyanoethoxymethyl)-nucleoside 3′-O-Oxazaphospholidine Monomers

(2012) Yohei Nukaga et al.   JOURNAL OF ORGANIC CHEMISTRY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Structure of (5′S)-8,5′-Cyclo-2′-deoxyguanosine in DNA

(2011) Hai Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!

(2010) Mark Gomelsky   MOLECULAR MICROBIOLOGY

Labeled Nucleoside Triphosphates with Reversibly Terminating Aminoalkoxyl Groups

(2010) Daniel Hutter et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

One-Flask Syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] Thiophosphate Analogues

(2010) Barbara L. Gaffney et al.   ORGANIC LETTERS

Thiophosphate Analogs of c-di-GMP: Impact on Polymorphism

(2009) Jianwei Zhao et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach

(2009) Natsuhisa Oka et al.   ORGANIC LETTERS

Stereocontrolled Solid-Phase Synthesis of OligonucleosideH-Phosphonates by an Oxazaphospholidine Approach

(2008) Naoki Iwamoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP

(2008) Hongbin Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Solid-Phase Synthesis of Stereoregular Oligodeoxyribonucleoside Phosphorothioates Using Bicyclic Oxazaphospholidine Derivatives as Monomer Units

(2008) Natsuhisa Oka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY