期刊
ORGANIC LETTERS
卷 11, 期 4, 页码 967-970出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol802910k
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资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) Japan
- New Energy and Industrial Technology Development Organization (NEDO) Japan
Oligoribonucleoside phosphorothioates (PS-ORNs) stereodefined at the phosphorus atoms were synthesized on solid support. Thermal denaturating experiments of the resultant PS-ORNs showed that a backbone consisting of (Sp)-PS-linkages as well as stereorandom PS-linkages had an unexpectedly large destabilizing effect on a PS-ORN-ORN duplex, whereas a backbone consisting of (Rp)-PS-linkages slightly stabilized a duplex.
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