Melatonin Cytotoxicity Is Associated to Warburg Effect Inhibition in Ewing Sarcoma Cells

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia

(2014) R. Jitschin et al.   BLOOD

Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy

(2014) Heinrich Kovar   EXPERT OPINION ON THERAPEUTIC TARGETS

Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-κβ

(2014) Josefa León et al.   JOURNAL OF PINEAL RESEARCH

Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer

(2013) Faton Agani et al.   CURRENT CANCER DRUG TARGETS

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

(2013) Mariano Bizzarri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mechanisms Involved in the Pro-Apoptotic Effect of Melatonin in Cancer Cells

(2013) Carmen Rodriguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α

(2013) Yanmin Zhang et al.   JOURNAL OF PINEAL RESEARCH

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin

(2012) G García-Santos et al.   BRITISH JOURNAL OF CANCER

Mitochondrial dysfunction and cancer metastasis

(2012) Emily I. Chen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

(2012) Simone Cardaci et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model

(2012) Kil-Jung Kim et al.   JOURNAL OF PINEAL RESEARCH

Energy metabolism in cancer cells: How to explain the Warburg and Crabtree effects?

(2012) Paolo Dell’ Antone   MEDICAL HYPOTHESES

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

(2011) S. Ramirez-Peinado et al.   CANCER RESEARCH

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

(2011) M. D. Mediavilla et al.   CURRENT MEDICINAL CHEMISTRY

Oxidative stress and therapeutic opportunities: focus on the Ewing’s sarcoma family of tumors

(2011) Danielle G Smith et al.   Expert Review of Anticancer Therapy

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells

(2011) Ana M. Sánchez-Sánchez et al.   FREE RADICAL RESEARCH

Therapeutic targeting of cancer cell metabolism

(2011) Chi V. Dang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pro-Oxidant Effect of Melatonin in Tumour Leucocytes: Relation with its Cytotoxic and Pro-Apoptotic Effects

(2010) Ignacio Bejarano et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cytotoxicity,radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucoseIn vitro

(2009) BS Dwarakanath   Journal of Cancer Research and Therapeutics

Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway

(2009) Sara Casado-Zapico et al.   JOURNAL OF PINEAL RESEARCH

The Warburg effect and mitochondrial stability in cancer cells

(2009) Vladimir Gogvadze et al.   MOLECULAR ASPECTS OF MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Melatonin modulates the expression of VEGF and HIF-1α induced by CoCl2in cultured cancer cells

(2007) Min Dai et al.   JOURNAL OF PINEAL RESEARCH