LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons
出版年份 2020 全文链接
标题
LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons
作者
关键词
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出版物
Frontiers in Neuroscience
Volume 14, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-05-15
DOI
10.3389/fnins.2020.00442
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition
- (2020) Anwesha Sanyal et al. MOVEMENT DISORDERS
- The effect of mutant GBA1 on accumulation and aggregation of α-synuclein
- (2019) Gali Maor et al. HUMAN MOLECULAR GENETICS
- Age- and α-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri
- (2019) Hideaki Matsui et al. Cell Reports
- LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
- (2019) Gregor Bieri et al. ACTA NEUROPATHOLOGICA
- Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)
- (2019) Philip Wing-Lok Ho et al. Autophagy
- LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function
- (2019) Rebecca Wallings et al. HUMAN MOLECULAR GENETICS
- Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease
- (2019) Paraskevi Krashia et al. Nature Communications
- LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson’s disease patients
- (2019) Daniel Ysselstein et al. Nature Communications
- Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
- (2018) Laura Pellegrini et al. HUMAN MOLECULAR GENETICS
- Religious Orders Study and Rush Memory and Aging Project
- (2018) David A. Bennett et al. JOURNAL OF ALZHEIMERS DISEASE
- Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons
- (2018) Jason Schapansky et al. NEUROBIOLOGY OF DISEASE
- ELISA method to detect α-synuclein oligomers in cell and animal models
- (2018) Louise Berkhoudt Lassen et al. PLoS One
- α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
- (2018) Iryna Prots et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers
- (2018) Sangjune Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Silencing of Glucocerebrosidase Gene in Drosophila Enhances the Aggregation of Parkinson's Disease Associated α-Synuclein Mutant A53T and Affects Locomotor Activity
- (2018) Salema B. Abul Khair et al. Frontiers in Neuroscience
- G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
- (2018) Salvatore Novello et al. NEUROBIOLOGY OF DISEASE
- LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
- (2018) Eun-Jin Bae et al. Nature Communications
- E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway
- (2018) Jia-qing Yan et al. MOLECULES
- Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression
- (2018) Priya Srikanth et al. Translational Psychiatry
- Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability
- (2017) Christina R. Muratore et al. Stem Cell Reports
- Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
- (2016) Ganqiang Liu et al. ANNALS OF NEUROLOGY
- Ade novocompound targeting α-synuclein improves deficits in models of Parkinson’s disease
- (2016) Wolfgang Wrasidlo et al. BRAIN
- Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
- (2016) Dena G. Hernandez et al. JOURNAL OF NEUROCHEMISTRY
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
- (2016) Alvaro Sanchez-Martinez et al. Scientific Reports
- LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
- (2016) Tomoki Kuwahara et al. Scientific Reports
- LRRK2 Pathways Leading to Neurodegeneration
- (2015) Mark R. Cookson Current Neurology and Neuroscience Reports
- Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
- (2015) Anastasia G. Henry et al. HUMAN MOLECULAR GENETICS
- Transmission of Soluble and Insoluble α-Synuclein to Mice
- (2015) Daryl Rhys Jones et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells
- (2015) Daniel Paull et al. NATURE METHODS
- Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils
- (2015) Atsushi Tsujimura et al. NEUROBIOLOGY OF DISEASE
- Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis
- (2015) Jean-Marc Taymans et al. TRENDS IN MOLECULAR MEDICINE
- Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons
- (2015) J C Koch et al. Cell Death & Disease
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
- (2014) J. Schapansky et al. HUMAN MOLECULAR GENETICS
- Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
- (2014) L. N. Hockey et al. JOURNAL OF CELL SCIENCE
- Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
- (2014) Laura A Volpicelli-Daley et al. Nature Protocols
- iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
- (2014) Chris M. Woodard et al. Cell Reports
- Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
- (2013) Yingsha Zhang et al. NEURON
- LRRK2 Affects Vesicle Trafficking, Neurotransmitter Extracellular Level and Membrane Receptor Localization
- (2013) Rossana Migheli et al. PLoS One
- GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
- (2012) A. Biosa et al. HUMAN MOLECULAR GENETICS
- G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
- (2012) Tatiana D. Papkovskaia et al. HUMAN MOLECULAR GENETICS
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A clinical and family history study of Parkinson's disease in heterozygousglucocerebrosidasemutation carriers
- (2012) Alisdair McNeill et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
- (2012) Kelly M Hinkle et al. Molecular Neurodegeneration
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- Neuropathology of sporadic Parkinson's disease: Evaluation and changes of concepts
- (2011) Kurt A. Jellinger MOVEMENT DISORDERS
- Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
- (2011) David Ramonet et al. PLoS One
- CNS expression of glucocerebrosidase corrects -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
- (2011) S. P. Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The risk of Parkinson’s disease in type 1 Gaucher disease
- (2010) Gilberto Bultron et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease
- (2010) Jérémie Vitte et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease
- (2010) T A Yacoubian et al. Cell Death & Disease
- Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
- (2009) Juliane Neumann et al. BRAIN
- Molecular pathogenesis of Parkinson disease: insights from genetic studies
- (2009) Thomas Gasser EXPERT REVIEWS IN MOLECULAR MEDICINE
- Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus
- (2009) Daniel del Toro et al. MOLECULAR BIOLOGY OF THE CELL
- Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34
- (2009) Li Chen et al. MOLECULAR MEMBRANE BIOLOGY
- Emerging roles of Wnts in the adult nervous system
- (2009) Nibaldo C. Inestrosa et al. NATURE REVIEWS NEUROSCIENCE
- Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease
- (2009) E. Sidransky et al. NEW ENGLAND JOURNAL OF MEDICINE
- N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)
- (2008) Ersin Selcuk Unal et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease
- (2007) J. Alegre-Abarrategui et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
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