Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease

Huntingtin Lowering Strategies for Disease Modification in Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEURON

Targeting Huntingtin Expression in Patients with Huntington’s Disease

(2019) Sarah J. Tabrizi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

(2019) Bryan Zeitler et al.   NATURE MEDICINE

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

(2019) Jong-Min Lee et al.   CELL

The pathobiology of perturbed mutant huntingtin protein–protein interactions in Huntington's disease

(2019) Erich E. Wanker et al.   JOURNAL OF NEUROCHEMISTRY

Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease

(2018) Diego Luis-Ravelo et al.   EXPERIMENTAL NEUROLOGY

Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic

(2018) Jana Miniarikova et al.   MOLECULAR THERAPY

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

Therapeutic approaches to Huntington disease: from the bench to the clinic

(2018) Nicholas S. Caron et al.   NATURE REVIEWS DRUG DISCOVERY

A role for autophagy in Huntington's disease

(2018) Katherine R. Croce et al.   NEUROBIOLOGY OF DISEASE

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

(2018) Rebecca Aron et al.   Nature Communications

Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation

(2018) Xiaoyun Xu et al.   Scientific Reports

Genetic modifiers of Mendelian disease: Huntington’s disease and the trinucleotide repeat disorders

(2017) Peter A. Holmans et al.   HUMAN MOLECULAR GENETICS

PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model

(2017) Alisia Carnemolla et al.   Frontiers in Cellular Neuroscience

The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function

(2017) Wojciech J. Szlachcic et al.   Frontiers in Molecular Neuroscience

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

(2016) Ian H. Kratter et al.   JOURNAL OF CLINICAL INVESTIGATION

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

(2016) Eduardo E. Arteaga-Bracho et al.   NEUROBIOLOGY OF DISEASE

Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

(2016) Jing Jin et al.   NEUROMOLECULAR MEDICINE

Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis

(2016) Guohao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review

(2016) Ting Zhao et al.   Frontiers in Molecular Neuroscience

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

Neuronal Aggregates: Formation, Clearance, and Spreading

(2015) Junghyun Lim et al.   DEVELOPMENTAL CELL

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease

(2015) Jing Jin et al.   HUMAN MOLECULAR GENETICS

Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy

(2015) Tiffany W Todd et al.   eLife

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

(2014) Lu-Shiun Her et al.   BRAIN PATHOLOGY

Huntingtin-lowering strategies in Huntington's disease: Antisense oligonucleotides, small RNAs, and gene editing

(2014) Neil Aronin et al.   MOVEMENT DISORDERS

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Ubiquitin–proteasome system involvement in Huntington’s disease

(2014) Zaira Ortega et al.   Frontiers in Molecular Neuroscience

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Polyglutamine Disease Toxicity Is Regulated by Nemo-like Kinase in Spinocerebellar Ataxia Type 1

(2013) H. Ju et al.   JOURNAL OF NEUROSCIENCE

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

(2012) Richard Grondin et al.   BRAIN

Nemo-like kinase, a multifaceted cell signaling regulator

(2012) Tohru Ishitani et al.   CELLULAR SIGNALLING

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Identifying polyglutamine protein species in situ that best predict neurodegeneration

(2011) Jason Miller et al.   Nature Chemical Biology

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model

(2011) Yong Cheng et al.   NEUROIMAGE

Huntington's Disease: Can Mice Lead the Way to Treatment?

(2011) Zachary R. Crook et al.   NEURON

Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins

(2011) David C. Butler et al.   PROGRESS IN NEUROBIOLOGY

Clearance of Mutant Proteins as a Therapeutic Target in Neurodegenerative Diseases

(2010) Dimitri Krainc   ARCHIVES OF NEUROLOGY

Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation

(2010) Z. Ortega et al.   JOURNAL OF NEUROSCIENCE

Proteasomal dysfunction in aging and Huntington disease

(2010) Xiao-Jiang Li et al.   NEUROBIOLOGY OF DISEASE

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Nemo-Like Kinase, an Essential Effector of Anterior Formation, Functions Downstream of p38 Mitogen-Activated Protein Kinase

(2009) E. Ohnishi et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease

(2008) Wenzhen Duan et al.   NEUROBIOLOGY OF DISEASE

The Ubiquitin-Proteasome Pathway in Huntington's Disease

(2008) Siddhartha Mitra et al.   TheScientificWorldJOURNAL