The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease

(2014) J. Chakraborty et al.   BEHAVIOURAL BRAIN RESEARCH

Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues

(2014) B. E. Wade et al.   JOURNAL OF NEUROSCIENCE

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

(2014) K. P. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-196a Ameliorates Phenotypes of Huntington Disease in Cell, Transgenic Mouse, and Induced Pluripotent Stem Cell Models

(2013) Pei-Hsun Cheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein

(2012) Pei-Hsun Cheng et al.   Brain Structure & Function

Huntingtonʼs disease

(2012) Ainhi D. Ha et al.   CURRENT OPINION IN NEUROLOGY

Late onset vascular dysfunction in the R6/1 model of Huntington’s disease

(2012) Awahan Rahman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease

(2012) Mark S. Hipp et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

Mutant huntingtin impairs immune cell migration in Huntington disease

(2012) Wanda Kwan et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective destruction of abnormal proteins by ubiquitin-mediated protein quality control degradation

(2012) Eric K. Fredrickson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease

(2011) Ming-Chang Chiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

(2011) Ana Roscic et al.   JOURNAL OF NEUROCHEMISTRY

Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease

(2011) H. Koga et al.   JOURNAL OF NEUROSCIENCE

Clearance of Mutant Proteins as a Therapeutic Target in Neurodegenerative Diseases

(2010) Dimitri Krainc   ARCHIVES OF NEUROLOGY

Clearance of mutant huntingtin

(2010) Xiao-Jiang Li et al.   Autophagy

New insights into cathepsin D in mammary tissue development and remodeling

(2010) Naira V. Margaryan et al.   CANCER BIOLOGY & THERAPY

Early autophagic response in a novel knock-in model of Huntington disease

(2010) Mary Y. Heng et al.   HUMAN MOLECULAR GENETICS

Inhibiting the ubiquitin–proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments

(2010) Xiang Li et al.   HUMAN MOLECULAR GENETICS

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

(2010) Ming-Chang Chiang et al.   HUMAN MOLECULAR GENETICS

Early or Late-Stage Anti-N-Terminal Huntingtin Intrabody Gene Therapy Reduces Pathological Features in B6.HDR6/1 Mice

(2010) Abigail Snyder-Keller et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation

(2010) Z. Ortega et al.   JOURNAL OF NEUROSCIENCE

Proteasomal dysfunction in aging and Huntington disease

(2010) Xiao-Jiang Li et al.   NEUROBIOLOGY OF DISEASE

Comprehensive analysis of expression pattern and promoter regulation of human autophagy-related genes

(2009) Yusuke Kusama et al.   APOPTOSIS

Formation of Polyglutamine Inclusions in a Wide Range of Non-CNS Tissues in the HdhQ150 Knock-In Mouse Model of Huntington's Disease

(2009) Hilary Moffitt et al.   PLoS One