Systemic effects of mitochondrial stress

Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress

(2020) Mario Ost et al.   EMBO REPORTS

Astrocyte‐specific deletion of the mitochondrial m ‐AAA protease reveals glial contribution to neurodegeneration

(2019) Sara Murru et al.   GLIA

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis

(2019) Sashaina E. Fanibunda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity

(2019) Jianfeng Lan et al.   Cell Reports

Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding

(2019) Jung Dae Kim et al.   Cell Metabolism

Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

(2019) Saara Forsström et al.   Cell Metabolism

Compromised Mitochondrial Protein Import Acts as a Signal for UPRmt

(2019) Stéphane G. Rolland et al.   Cell Reports

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks

(2019) Alexander J. Anderson et al.   Open Biology

FSHR-1/GPCR Regulates the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans

(2019) Sungjin Kim et al.   GENETICS

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

(2018) Aida Rodríguez‐Nuevo et al.   EMBO JOURNAL

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Nuclear genes involved in mitochondrial diseases caused by instability of mitochondrial DNA

(2018) Joanna Rusecka et al.   JOURNAL OF APPLIED GENETICS

Human Aging and Longevity Are Characterized by High Levels of Mitokines

(2018) Maria Conte et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Assembly of the membrane domain of ATP synthase in human mitochondria

(2018) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

(2018) Olesia Ignatenko et al.   Nature Communications

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

(2018) Kook Hwan Kim et al.   Scientific Reports

The Aging Mitochondria

(2018) Pierre Theurey et al.   Genes

Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases

(2018) Serge Grazioli et al.   Frontiers in Immunology

Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?

(2018) José Pedro Castro et al.   Frontiers in Endocrinology

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

(2018) Shuya Kasai et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast

(2018) Katja G. Hansen et al.   SCIENCE

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

(2018) Lisa Michelle Restelli et al.   Cell Reports

N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation

(2018) Chengchuan Ma et al.   NATURE CELL BIOLOGY

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder

(2018) Daniele Vigli et al.   NEUROPHARMACOLOGY

Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease

(2018) Sandra Franco-Iborra et al.   Cell Death & Disease

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

(2018) Katharina Timper et al.   Cell Reports

Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity

(2017) V W Tsai et al.   INTERNATIONAL JOURNAL OF OBESITY

Mitochondrial energy generation disorders: genes, mechanisms and clues to pathology

(2017) Ann E. Frazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

(2017) Lotti M. Supplie et al.   JOURNAL OF NEUROSCIENCE

Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome

(2017) Daniela Valenti et al.   NEUROPHARMACOLOGY

Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model

(2017) Wei Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of submitochondrial protein distribution

(2017) F.-Nora Vögtle et al.   Nature Communications

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response

(2016) Li-Wa Shao et al.   CELL RESEARCH

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt

(2016) Dominic Seiferling et al.   EMBO REPORTS

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

The genetics and pathology of mitochondrial disease

(2016) Charlotte L Alston et al.   JOURNAL OF PATHOLOGY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Synchronized mitochondrial and cytosolic translation programs

(2016) Mary T. Couvillion et al.   NATURE

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes

(2016) Takaaki Murakami et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

(2016) Mario Ost et al.   Molecular Metabolism

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

(2016) Xingya Wang et al.   Aging-US

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses

(2015) Huifang Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

MitoMiner v3.1, an update on the mitochondrial proteomics database

(2015) Anthony C. Smith et al.   NUCLEIC ACIDS RESEARCH

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice

(2015) Christopher E. Wall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity

(2015) Peter M. Douglas et al.   Cell Reports

Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy

(2014) Sungwoo Park et al.   Autophagy

Complex IV-deficientSurf1−/−mice initiate mitochondrial stress responses

(2014) Daniel A. Pulliam et al.   BIOCHEMICAL JOURNAL

Mammalian Fe–S cluster biogenesis and its implication in disease

(2014) Lena K. Beilschmidt et al.   BIOCHIMIE

Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

(2014) Yibo Wu et al.   CELL

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Humanin and Age-Related Diseases: A New Link?

(2014) Zhenwei Gong et al.   Frontiers in Endocrinology

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

(2013) D. Milenkovic et al.   HUMAN MOLECULAR GENETICS

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

(2013) Qinfang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Landscape of the mitochondrial Hsp90 metabolome in tumours

(2013) Young Chan Chae et al.   Nature Communications

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Step-Wise Methylation of Histone H3K9 Positions Heterochromatin at the Nuclear Periphery

(2012) Benjamin D. Towbin et al.   CELL

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

(2012) I Pimenta de Castro et al.   CELL DEATH AND DIFFERENTIATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo

(2011) ffolliott M. Fisher et al.   ENDOCRINOLOGY

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients

(2010) Edward J. Gane et al.   LIVER INTERNATIONAL

Tissue-specific differences in mitochondrial activity and biogenesis

(2010) Erika Fernández-Vizarra et al.   MITOCHONDRION

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

(2009) Pernille Hojman et al.   DIABETES

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

(2009) Jeremy M. Van Raamsdonk et al.   PLoS Genetics

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells

(2007) Pei-Tzu Yang et al.   DEVELOPMENTAL CELL