Inter-organelle Communication in the Pathogenesis of Mitochondrial Dysfunction and Insulin Resistance

Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice

(2019) Stacey N. Keenan et al.   DIABETES

Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network

(2019) Amy E. Vincent et al.   Cell Reports

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis

(2019) Yvette C. Wong et al.   TRENDS IN CELL BIOLOGY

Impact of Lipotoxicity on Tissue “Cross Talk” and Metabolic Regulation

(2019) Magdalene K. Montgomery et al.   PHYSIOLOGY

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

(2019) Ilan Y. Benador et al.   Cell Metabolism

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

(2019) Wondwossen M Yeshaw et al.   eLife

MITOL prevents ER stress‐induced apoptosis by IRE1α ubiquitylation at ER–mitochondria contact sites

(2019) Keisuke Takeda et al.   EMBO JOURNAL

Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects

(2019) Giuseppe Paradies et al.   Cells

MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes

(2019) Christophe A.C. Freyre et al.   MOLECULAR CELL

Disruption of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Contributes to Muscle Insulin Resistance in Mice and Humans

(2018) Emily Tubbs et al.   DIABETES

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2

(2018) Anne Gemmink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

(2018) Pamela A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK4 Augments ER-Mitochondria Contact to Dampen Skeletal Muscle Insulin Signaling During Obesity

(2018) Themis Thoudam et al.   DIABETES

Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid–induced insulin resistance

(2017) Satoko Shinjo et al.   EXPERIMENTAL CELL RESEARCH

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

(2017) Anne Gemmink et al.   JOURNAL OF PHYSIOLOGY-LONDON

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges

(2017) Manuela Lavorato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piecing Together the Patchwork of Contact Sites

(2017) Alberto T. Gatta et al.   TRENDS IN CELL BIOLOGY

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

(2017) Yi Liu et al.   Translational Neurodegeneration

Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes

(2017) Charles Thivolet et al.   PLoS One

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians

(2017) Anne Gemmink et al.   Scientific Reports

The Perilipins: Major Cytosolic Lipid Droplet–Associated Proteins and Their Roles in Cellular Lipid Storage, Mobilization, and Systemic Homeostasis

(2016) Alan R. Kimmel et al.   Annual Review of Nutrition

A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

(2016) Michal Eisenberg-Bord et al.   DEVELOPMENTAL CELL

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

(2016) David M. Booth et al.   MOLECULAR CELL

ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis

(2016) Jinjiang Fan et al.   MOLECULAR ENDOCRINOLOGY

Diabetes mellitus statistics on prevalence and mortality: facts and fallacies

(2016) Paul Zimmet et al.   Nature Reviews Endocrinology

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets

(2016) Nora Kory et al.   TRENDS IN CELL BIOLOGY

Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver

(2016) Pierre Theurey et al.   Journal of Molecular Cell Biology

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

(2015) Liang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Peroxisome-mitochondria interplay and disease

(2015) Michael Schrader et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

(2015) Y Teng et al.   ONCOGENE

Unraveling the roles of PLIN5: linking cell biology to physiology

(2015) Rachael R. Mason et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

(2014) Ciaran E. Fealy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

(2014) Rachael R. Mason et al.   Molecular Metabolism

Organization and function of membrane contact sites

(2013) Sebastian C.J. Helle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction

(2013) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier

(2013) Nina M. Pollak et al.   JOURNAL OF LIPID RESEARCH

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

(2013) P.M. Coen et al.   Obesity

Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria

(2013) L. L. Lackner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids of mitochondria

(2013) Susanne E. Horvath et al.   PROGRESS IN LIPID RESEARCH

Perilipin family (PLIN) proteins in human skeletal muscle: the effect of sex, obesity, and endurance training

(2012) Sandra J. Peters et al.   Applied Physiology Nutrition and Metabolism

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis

(2011) Guillaume Pidoux et al.   EMBO JOURNAL

Mitochondrial Dysfunction andβ-Cell Failure in Type 2 Diabetes Mellitus

(2011) Zhongmin Alex Ma et al.   Experimental Diabetes Research

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

(2011) Madeleen Bosma et al.   HISTOCHEMISTRY AND CELL BIOLOGY

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

(2011) S. M. Horner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of perilipins in human skeletal musclein vitroandin vivoin relation to diet, exercise and energy balance

(2011) I.M.F. Gjelstad et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Mitochondrial Dynamics in Diabetes

(2010) Yisang Yoon et al.   ANTIOXIDANTS & REDOX SIGNALING

Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction

(2010) Ryota Iwasawa et al.   EMBO JOURNAL

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance

(2009) Antonio Zorzano et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE